Abstract
Blood vessels are involved in the regulation and maintenance of all tissues and are key players in the development of disease. In adults, the destabilization of blood vessels, often seen in association with induced vascular growth or remodeling, are driving pathological phenotypes such as inflammation, edema, deregulated tissue growth/regeneration and systemic dissemination of tumor cells leading to metastasis or bacteria/bacterial products leading to sepsis. In order to target pathological blood vessel growth (angiogenesis) or destabilization as means to treat human disease, it is important to understand how blood vessels are structured, function, the mechanisms regulating physiological and pathological angiogenesis and how these processes differ. Here we will present some general concepts related to vascular biology and angiogenesis, as well as lymphangiogenesis, i.e. the growth of the lymphatic vascularture. The aim of this chapter is to provide a foundation for understanding mechanisms of angiogenesis in health and disease, which can be applied more specifically to various aspects of skin biology and pathologies in other chapters. We will also identify and discuss aspects of angiogenesis which remain poorly understood and present suggestions for further research in this area.
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Jensen, L., Cao, Y. (2017). Angiogenesis: General Concepts. In: Arbiser, J. (eds) Angiogenesis-Based Dermatology. Springer, London. https://doi.org/10.1007/978-1-4471-7314-4_1
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