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Pathogenesis

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Operative Strategies in Inflammatory Bowel Disease

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Abstract

Despite intensive investigation over the past several decades, the cause and mechanism of inflammatory bowel disease (IBD) remain unknown. The pathogenesis of IBD is certainly more complex than a simple single cause-and-effect relationship, and probably results from the interaction of predisposing genetic factors, exogenous and endogenous triggers, and host modifying factors (1-3). The outcome of these multiple interactions is the chronic remitting and relapsing inflammatory process recognized clinically as ulcerative colitis or Crohn’s disease. Although we, as yet, do not fully understand the intimate mechanisms of the complicated host-environment relationship which result in IBD, research in the areas of genetics, intestinal microbiology and ecology, immunology, and experimental animal models have greatly increased our understanding of the individual components of the disease process and how they may interrelate. This chapter will synthetically review the state-of-the-art knowledge on the possible causes and mechanisms of ulcerative colitis and Crohn’s disease.

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Authors
  1. Jeffrey A. Katz
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  2. Claudio Fiocchi
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Editors and Affiliations

  1. Section of General Surgery, University of Chicago, Chicago, IL, 60637, USA

    Fabrizio Michelassi MD (Professor and Chief) (Professor and Chief)

  2. Division of Colon and Rectal Surgery, Mount Sinai Medical Center, New York, NY, 10029, USA

    Jeffrey W. Milsom MD (Professor and Chief) (Professor and Chief)

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Katz, J.A., Fiocchi, C. (1999). Pathogenesis. In: Michelassi, F., Milsom, J.W. (eds) Operative Strategies in Inflammatory Bowel Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1396-3_3

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