Abstract
During no other time in postnatal human development are there such massive changes in body composition as in puberty. GH and IGF-I production are greatly enhanced, and insulin and sex steroidal hormones increase during this period, allowing the child’s transformation into a fully grown adult with reproductive maturity. Some of the changes observed are directly related to the enhancement of whole-body protein synthetic rates and the increase of specific protein pools as well as to the increased calcium absorption and retention, leading to increased bone mineralization, net bone accrual, and eventual achievement of peak bone mass. Safe and reproducible investigative techniques are now available that permit the assessment of protein, calcium, and glucose kinetics, as well as body compositional changes. These tools are uniquely useful in human studies, particularly pediatric studies, as they do not involve radioactive materials, and are relatively noninvasive and nontoxic. We have studied the relative contributions of these anabolic hormones to the metabolic changes of puberty and assessed the effects of these hormones in chronic catabolic states.
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Mauras, N. (1999). Metabolic Effects of GH/IGF-I, Testosterone, and Estrogen: Studies in Children and Adults. In: Veldhuis, J.D., Giustina, A. (eds) Sex-Steroid Interactions with Growth Hormone. Proceedings in the Serono Symposia USA Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1546-2_30
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DOI: https://doi.org/10.1007/978-1-4612-1546-2_30
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-98810-8
Online ISBN: 978-1-4612-1546-2
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