Abstract
Ovarian cancer is the most common fatal gynecological malignancy, responsible for more deaths than all other forms of gynecological cancer combined. Lifetime risks for development of the disease are estimated to lie in the range of 1 in 80 to 1 in 100, with a population prevalence of approximately 30 per 100,000 women. Most patients with the disease present at an advanced stage, with 30% surviving for 5 years with a diagnosis of stage 3 epithelial malignancy (representing local and pelvic extraperitoneal spread) while only 5%–10% survive with stage 4 disease (disseminated malignancy).
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References
Burger HG, Fuller PJ. The inhibin/activin family and ovarian cancer. Trends Endocrinol Metab 1996;7:197–202.
Lappöhn RE, Burger HG, Bouma J, Bangah M, Krans M, de Bruijn H. Inhibin as a marker for granulosa-cell tumors. N Engl J Med 1989;321:790–3.
Kauppila A, Bangah M, Burger HG, Martikainen H. GnRH agonist therapy in advanced/recurrent granulosa cell tumors: further evidence of a role of inhibin monitoring response to treament. Gynecol Endocrinol 1992;6:271–4.
Healy DL, Burger HG, Mamers P, Jobling T, Bangah M, Quinn M, et al. Inhibin: a serum marker for mucinous ovarian cancers. N Engl J Med 1993;329:1539–42.
Burger HG. Clincial review—Clinical utility of inhibin measurements. J Clin Endocrinol Metab 1993;76:1391–6.
Jobling T, Mamers P, Healy DL, MacLachlan V, Burger HG, Quinn M, et al. A prospective study of inhibin in granulosa cell tumors of the ovary. Gynecol Oncol 1994;55:285–9.
Groome NP, Illingworth PG, O’Brien M, Cooke I, Ganesan TS, Baird DT, et al. Detection of dimeric inhibin throughout the human menstrual cycle by two-site enzyme immunoassay. Clin Endocrinol 1994;40:717–23.
Groome NP, Illingworth PJ, O’Brien M, Roger PAL, Rodger FE, Mather JP, et al. Measurement of dimeric inhibin B throughout the human menstrual cycle. J Clin Endocrinol Metab 1996;81:1401–5.
Burger HG, Robertson DM, Cahir N, Mamers P, Healy DL, Jobling T, et al. Characterisation of inhibin immunoreactivity in post-menopausal women with ovarian tumours. Clin Endocrinol 1996;44:413–8.
Cooke I, O’Brien M, Charnock FM, Groome NP, Ganesan TS. Inhibin as a marker for ovarian cancer. Br J Cancer 1995;71:1046–50.
Robertson DM, Burger HG, Sullivan J, Cahir N, Groome N, Poncelet E, et al. Biological and immunological characterisation of inhibin forms in human plasma. J Clin Endocrinol Metab 1996;81:669–76.
Sluijmer AV, Heineman MJ, Evers JLH, de Jong FH. Peripheral vein, ovarian vein and ovarian tissue levels of inhibin in a postmenopausal patient with a granulosa cell tumour. Acta Endocrinol (Copenh) 1993;129:311–14.
Gurusinghe CJ, Healy DL, Jobling T, Mamers P, Burger HG. Inhibin and activin are demonstrable by immunohistochemisty in ovarian tumor tissue. Gynecol Oncol 1995;57:27–32.
Matzuk MM, Finegold MK, Su JG, Hsueh AJ, Bradley A. Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice. Nature (Lond) 1992;360:313–9.
Coerver KA, Woodruff TK, Finegold MJ, Mather J, Bradley A, Matzuk MM. Activin signalling through activin receptor type II causes the cachexia-like symptoms in inhibin-deficient, mice. Mol Endocrinol 1996;10:534–43.
Shen Y, Mamers P, Jobling T, Burger HG, Fuller PJ. Absence of the previously reported G-protein oncogence (gip21in ovarian granulosa cell tumors. J Clin Endocrinol Metab 1996;81:4159–61.
Lyons J, Landis CA, Harsh G, Vallar L, Grunewald K, Feichtinger H. Two G protein oncogenes in human endocrine tumors. Science 1990;249:655–9.
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Burger, H.G. et al. (1997). Production of Inhibin-Related Peptides by Ovarian Tumors. In: Aono, T., Sugino, H., Vale, W.W. (eds) Inhibin, Activin and Follistatin. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1874-6_15
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DOI: https://doi.org/10.1007/978-1-4612-1874-6_15
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