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New Perspectives on Ca2+ Influx in Mast Cells

  • Chapter
Signal Transduction in Mast Cells and Basophils

Abstract

The importance of extracellular calcium for anaphylactic release of histamine was suggested by experiments of Mongar and Schild in 1958, years before the discovery of IgE or its high-affinity receptor, the FcεRI.1 Many subsequent studies using radiotracer flux and fluorescent Ca2+ indicators revealed that multivalent binding of antigen to the IgE-FcεRI complex elicits the release of internal as well as the influx of extracellular Ca2+, and there appears to be a causal relation between these two events. For the RBL-2H3 mast cell line used in many of these studies,2 it is generally agreed that Ca2+ influx is crucial for antigen-induced secretion of preformed inflammatory mediators.3

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Authors
  1. Michael A. McCloskey
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Editors and Affiliations

  1. Department of Biochemistry, Haddasah Medical School, Hebrew University, Jerusalem, 91120, Israel

    Ehud Razin

  2. Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bathesda, MD, 20892-1820, USA

    Juan Rivera

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McCloskey, M.A. (1999). New Perspectives on Ca2+ Influx in Mast Cells. In: Razin, E., Rivera, J. (eds) Signal Transduction in Mast Cells and Basophils. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2154-8_17

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  • DOI: https://doi.org/10.1007/978-1-4612-2154-8_17

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