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Structure Activity Relationships for Adenine Nucleotide Receptors on Mast Cells, Human Platelets, and Smooth Muscle

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Purines in Cellular Signaling

Abstract

Extracellular adenine nucleotides, adenosine 5′-monophosphate (AMP), adenosine 5′-diphosphate (ADP) and adenosine 5′-triphosphate (ATP) are active on mast cells, platelets and smooth muscle. These P2 purinoceptor-mediated actions have very different structure-activity relationships, which has lead to a subdivision into P2Z mast cell receptors, P2T platelet receptors, and P2Y inhibitory and P2X excitatory receptors on smooth muscle (Burnstock et al., 1985; Gordon, 1986).

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Authors
  1. N. J. Cusack
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  2. S. M. O. Hourani
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Editor information

Editors and Affiliations

  1. Laboratory of Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, 20892, USA

    Kenneth A. Jacobson PhD

  2. Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, 20892, USA

    John W. Daly PhD

  3. Laboratory of Cellular Metabolism, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, 20892, USA

    Vincent Manganiello MD, PhD

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© 1990 Springer-Verlag New York Inc.

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Cusack, N.J., Hourani, S.M.O. (1990). Structure Activity Relationships for Adenine Nucleotide Receptors on Mast Cells, Human Platelets, and Smooth Muscle. In: Jacobson, K.A., Daly, J.W., Manganiello, V. (eds) Purines in Cellular Signaling. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3400-5_37

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  • DOI: https://doi.org/10.1007/978-1-4612-3400-5_37

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7996-9

  • Online ISBN: 978-1-4612-3400-5

  • eBook Packages: Springer Book Archive

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