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Allogeneic Bone Marow Transplantation in Leukemia

  • Conference paper
Recent Advances and Future Directions in Bone Marrow Transplantation

Part of the book series: Experimental Hematology Today—1987 ((HEMATOLOGY,volume 1987))

  • 33 Accesses

Abstract

Erradication of leukemia by high dose chemotherapy and total body irradiation (TBI) and the capacity of hemopoietic stem cells to repopulate the marrow form the basic concept of bone marrow transplantation (BMT) in leukemia. First attempts at allogeneic BMT were made soon after the discovery of the hemopoietic stem cell. They all failed because of rejection and Graft-versus-Host disease (GvHD) (1). The recognition of the major histocompatibility complex was the basis of the first successful BMT’s in immune defiency syndromes where HLA-identical siblings served as donors (2–4). Results of BMT in leukemia, however, remained unsatisfactory because it was used almost exclusively for terminally ill patients with end-stage disease.

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Author information

Authors and Affiliations

  1. Division of Hematology, Department of Internal Medicine, Kantonsspital, University of Basel, Basel, Switzerland

    Bruno Speck, Alois Gratwohl, André Tichelli & Catherine Nissen

Authors
  1. Bruno Speck
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  2. Alois Gratwohl
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  3. André Tichelli
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  4. Catherine Nissen
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Editor information

Editors and Affiliations

  1. Department of Physiology, Uniformed Services University of the Health Sciences, School of Medicine, Bethesda, Maryland, 20817, USA

    Siegmund J. Baum Ph.D.

  2. Department of Oncology, The John Hopkins Hospital, Baltimore, Maryland, 21205, USA

    George W. Santos M.D. (Professor of Oncology and Medicine) (Professor of Oncology and Medicine)

  3. Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan

    Fumimaro Takaku M.D. (Professor) (Professor)

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© 1988 Springer-Verlag New York Inc.

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Speck, B., Gratwohl, A., Tichelli, A., Nissen, C. (1988). Allogeneic Bone Marow Transplantation in Leukemia. In: Baum, S.J., Santos, G.W., Takaku, F. (eds) Recent Advances and Future Directions in Bone Marrow Transplantation. Experimental Hematology Today—1987, vol 1987. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3762-4_21

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  • DOI: https://doi.org/10.1007/978-1-4612-3762-4_21

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-8339-3

  • Online ISBN: 978-1-4612-3762-4

  • eBook Packages: Springer Book Archive

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