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Human and Rodent Natural Killer Cytotoxic Factors (NKCF)

Characterization and Their Role in the NK Lytic Mechanism

  • Chapter
Leukolysins and Cancer

Part of the book series: Contemporary Biomedicine ((CB,volume 8))

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Abstract

Natural killer (NK) cells are a subpopulation of lymphocytes with the capacity to lyse certain types of tumor cells in an NK cell-mediated cytotoxicity (CMC) reaction. Since these cells exist in the absence of any known immunization process, they are thought to function in the first line of defense against newly arising tumors and infections. For these reasons, the understanding of the NK lytic mechanism, as well as its regulation, has been a strong interest in basic cancer research.

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Authors
  1. Susan C. Wright
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  2. Benjamin Bonavida
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Editor information

Editors and Affiliations

  1. Bionetics Research Inc., Rockville, Maryland, USA

    Janet H. Ransom

  2. Biological Therapeutics Branch, Biological Response Modifiers Program, Division of Cancer Treatmen, National Cancer Institute, Frederick Cancer Research Facility, Frederick, Maryland, USA

    John R. Ortaldo

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© 1988 The Humana Press Inc.

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Wright, S.C., Bonavida, B. (1988). Human and Rodent Natural Killer Cytotoxic Factors (NKCF). In: Ransom, J.H., Ortaldo, J.R. (eds) Leukolysins and Cancer. Contemporary Biomedicine, vol 8. Humana Press. https://doi.org/10.1007/978-1-4612-4586-5_7

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  • DOI: https://doi.org/10.1007/978-1-4612-4586-5_7

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8938-8

  • Online ISBN: 978-1-4612-4586-5

  • eBook Packages: Springer Book Archive

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