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Tachykinin-Induced Phosphatidylinositol Turnover in Hamster Urinary Bladder

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Substance P and Neurokinins

Abstract

In recent years. substance P and related tachykinins have been shown to stimulate inositol phospholipid hydrolysis in a variety of tissues, including rat salivary gland [1], guinea pig ileum longitudinal muscle and rat hypothalamus [2]. In these tissues substance P, eledoisin and substance P methyl ester possess similar nanomolar potencies at inducing this response suggesting that inositol phospholipid breakdown is associated with SP-P receptor activation [2]. However. in slices of rat ileum longitudinal muscle. eledoisin is considerably more potent than substance P at stimulating inositol phospholipid hydrolysis suggesting that in some tissues this response may be mediated by a SP-E receptor [3]. In order to investigate further the association of SP-E receptors with inositol phospholipid breakdown, we examined tachykinin-induced inositol-l-phosphate production in slices of hamster urinary bladder, a tissue whose contractile response exhibits a typical SP-E receptor profile [4].

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Author information

Authors and Affiliations

  1. Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Harlow, England

    K. J. Watling, N. Suman-Chauhan & D. R. Bristow

Authors
  1. K. J. Watling
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  2. N. Suman-Chauhan
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  3. D. R. Bristow
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Editor information

Editors and Affiliations

  1. Department of Physiology, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    James L. Henry Ph.D.

  2. Department of Physiology, University of Montreal, C.P. 6208, Montreal, Quebec, H3C 3T8, Canada

    Rejean Couture Ph.D.

  3. Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    A. Claudio Cuello M.D.

  4. MRC Group in Molecular Endocrinology, Centre Hospitalier de L’Universite, Laval, Quebec, G1V 4G2, Canada

    Georges Pelletier Ph.D.

  5. Douglas Hospital Research Centre and Department of Psychiatry, McGill University, Verdun, Quebec, H4H 1R3, Canada

    Remi Quirion Ph.D.

  6. Department of Pharmacology, Medical School, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada

    Domenico Regoli M.D.

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© 1987 Springer-Verlag New York Inc.

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Watling, K.J., Suman-Chauhan, N., Bristow, D.R. (1987). Tachykinin-Induced Phosphatidylinositol Turnover in Hamster Urinary Bladder. In: Henry, J.L., Couture, R., Cuello, A.C., Pelletier, G., Quirion, R., Regoli, D. (eds) Substance P and Neurokinins. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4672-5_20

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  • DOI: https://doi.org/10.1007/978-1-4612-4672-5_20

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9109-1

  • Online ISBN: 978-1-4612-4672-5

  • eBook Packages: Springer Book Archive

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