Abstract
Sarcoidosis is one member of a large family of granulomatous disorders in which the common denominator is the histology of epithelioid cell granulomas. Like many other members of this loose-knit family, its etiology is unknown. It is a multisystem disorder that most commonly affects young adults presenting with intrathoracic, skin, and eye lesions. The diagnosis is most secure when clinicoradiographic findings are supported by histologic evidence of widespread noncaseating epithelioid cell granulomas in more than one system or by a positive Kveim-Siltzbach skin test. There is evidence of depression of delayed-type hypersensitivity with impairment of thymus-mediated suppressor T cells in the peripheral blood but with evidence of increased numbers and activity of helper T cells in the lungs and in bronchoalveolar fluid. These helper T cells activate B cells to produce raised serum immunoglobulins, raised lambda and kappa light chains, and increased titers of serum antibodies against many antigens. Other common features are circulating immune complexes also hypercalciuria with or without hypercalcemia.
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References
Cushman DW, Cheung HS: Spectrophotometry assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem Pharmacol 20:1637–1639, 1971
Friedland J, Silverstein E: A sensitive fluorimetric assay for serum angiotensin-converting enzyme. Am J Clin Pathol 66:416–424, 1976
Hunninglake SW, Crystal RG: Pulmonary sarcoidosis: A disorder mediated by excess helper T lymphocyte activity at sites of disease activity. N Engl J Med 305:429–434, 1981
Israel H: Chlorambucil and methotrexate in sarcoidosis. Proceedings of the Fifth International Conference on Sarcoidosis. Prague, Charles University, 1971, pp 632–634
James DG, Carstairs LS, Trowell J, Sharma OP: Treatment of sarcoidosis. Lancet 2:526–529, 1967
James DG, Neville E, Siltzbach LE: A worldwide review of sarcoidosis. Proc NY Acad Sci 278:321–333, 1976
James DG, Jones Williams W: Immunology of sarcoidosis. Am J Med 72:5–8, 1982
James EMV, Jones Williams W: Fine structure and histochemistry of epithelioid cells in sarcoidosis. Thorax 29:115–120, 1974
Jones Williams W: Sarcoidosis 1977. Beitr Pathol 160:325–336, 1977
Kveim A: En ny og spesifik kutan-reackjon ved Boeck’s sarcoid. Nord Med 9: 169 – 172, 1941
Neville E, Carstairs LS, James DG: Sarcoidosis of bone. Q J Med 46:215–227, 1976
Neville E, James DG, Brewerton DA, James DCO, Cockburn C, Fenichal B: HLA antigens and clinical features of sarcoidosis. Eighth International Conference on Sarcoidosis. Cardiff, Alpha Omega Publishing, 1980, pp 201–203
Siltzbach LE, Ehrlich JC: Nickerson-Kveim reaction in sarcoidosis. Am J Med 16:790–803, 1954
Silverstein E, Friedland J, Lyons HA, Gourin A: Elevation of angiotensin-converting enzyme in granulomatous lymph nodes and serum in sarcoidosis: Clinical and possible pathogenic significance. Ann NY Acad Sci 278:498–513, 1976
Studdy PR, Bird R, James DG, Sherlock S: Serum angiotensin-converting enzyme (SACE) in sarcoidosis and other granulomatous disorders. Lancet 2:1331–1334, 1978
Studdy PR, Bird R, Neville E, James DG: Biochemical findings in sarcoidosis. J Clin Pathol 33:528–533, 1980
James DG, Thomson AD: The Kveim test in sarcoidosis. Q J Med XXIV:49–59, 1955
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© 1984 Springer-Verlag New York Inc.
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James, D.G., Williams, W.J. (1984). Sarcoidosis of the Lymph Nodes. In: Molander, D.W. (eds) Diseases of the Lymphatic System. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5198-9_8
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DOI: https://doi.org/10.1007/978-1-4612-5198-9_8
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