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Rodent Models To ExamineIn Vivo Hormonal Regulation of Mammary Gland Tumorigenesis

  • Chapter
Cellular and Molecular Biology of Mammary Cancer

Abstract

The experimental demonstration of the influence of hormones on the genesis of mammary tumors in rodents was begun in 1913 by Lathrop and Loeb, who demonstrated that mammary tumors were more frequent in outbred multiparous mice than in nulliparous mice of the same strain (1). Three years later, Lathrop and Leob reported that ovariectomy of mice at an early age either completely inhibited or greatly delayed the appearance of mammary tumors (2). Since these reports, countless numbers of studies have been reported documenting the exquisite control by the endocrine system of the genesis, development and growth of the rodent mammary tumor. The purpose of this chapter is to provide an assemblage of the currentin vivo mouse and rat mammary tumor models most commonly utilized by the tumor biologist intent on understanding mammary tumor — hormonal regulatory processes; a succinct review of the endocrine responsiveness of these mammary tumor models is provided.

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Authors and Affiliations

  1. Department of Anatomy, Michigan State University, East Lansing, Michigan, 48824, USA

    Clifford W. Welsch

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  1. Clifford W. Welsch
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  1. Baylor College of Medicine, Houston, Texas, USA

    Daniel Medina

  2. National Cancer Institute, Bethesda, Maryland, USA

    William Kidwell  & Elizabeth Anderson  & 

  3. Michigan Cancer Foundation, Detroit, Michigan, USA

    Gloria Heppner

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© 1987 Plenum Press, New York

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Welsch, C.W. (1987). Rodent Models To ExamineIn Vivo Hormonal Regulation of Mammary Gland Tumorigenesis. In: Medina, D., Kidwell, W., Heppner, G., Anderson, E. (eds) Cellular and Molecular Biology of Mammary Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0943-7_10

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  • DOI: https://doi.org/10.1007/978-1-4613-0943-7_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-42761-9

  • Online ISBN: 978-1-4613-0943-7

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