Abstract
Clinically prominent skeletal muscle dysfunction and wasting are found not only in uremia (1) but also in patients suffering from both primary hyperparathyroidism (2, 3) and glucocorticoid hormone are frequently observed in uremic patients (6). In addition, Wernze reported a twofold increase of plasma corticosterone 6 and 24 hours after bilateral nephrectomy in the rat (7). This finding corresponded well with former observations by Bondy et al., who were able to demonstrate a decrease of blood urea nitrogen after adrenalectomy in acutely uremic rats (8). From a metabolic point of view, net degradation of skeletal muscle proteins with a concomitant excessive release of amino acids has been reported in uremia (9). Moreover, enhanced muscle protein breakdown was also found to be caused by high levels of parathyroid hormone (10) as well as glucocorticoids (11 - 13).
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© 1988 Plenum Press, New York
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Schaefer, R.M. et al. (1988). Hormonal Regulation of Muscle Protein Catabolism in Acutely Uremic Rats: Effect of Adrenalectomy and Parathyroidectomy. In: Hörl, W.H., Heidland, A. (eds) Proteases II. Advances in Experimental Medicine and Biology, vol 240. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1057-0_30
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DOI: https://doi.org/10.1007/978-1-4613-1057-0_30
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