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Molecular Basis for Depressed Contractile Performance in Human Heart Failure

  • Chapter
Heart Hypertrophy and Failure

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 169))

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Abstract

The failing heart is characterized by a cardiac output inadequate to meet the metabolic needs of the peripheral organs and tissues. The key mechanical features of this deficiency are a raduction in the rate of pressure development, velocity of circumferential shortening, and the rate of relaxation [1–3]. The mechanical performance of heart muscle (nonfailing and failing) is directly dependent upon the characteristics of the myosin-actin cross-bridge cycle in conjunction with the degree and rate of myocardial activation and inactivation (calcium cycling) [4–9]. In order to better understand the contribution of contractile and excitation-contraction coupling changes found in heart failure as well as the molecular changes underlying them, mechanical and myothermal measurements were carried out on isolated strips of human heart muscle from nonfailing and failing hearts [mitral regurgitation (volume overload), idiopathic dilated cardiomyopathy].

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Authors
  1. Norman R. Alpert
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  2. Louis A. Mulieri
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  3. Gerd Hasenfuss
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Editor information

Editors and Affiliations

  1. MRC Group in Experimental Cardiology Division of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, 351 Taché Avenue, Winnipeg, Manitoba, R2H 2A6, Canada

    Naranjan S. Dhalla (Distinguished Professor), Grant N. Pierce (Professor), Vincenzo Panagia (Professor) & Robert E. Beamish (Professor Emeritus) (Distinguished Professor),  (Professor),  (Professor) &  (Professor Emeritus)

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© 1995 Kluwer Academic Publishers

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Alpert, N.R., Mulieri, L.A., Hasenfuss, G. (1995). Molecular Basis for Depressed Contractile Performance in Human Heart Failure. In: Dhalla, N.S., Pierce, G.N., Panagia, V., Beamish, R.E. (eds) Heart Hypertrophy and Failure. Developments in Cardiovascular Medicine, vol 169. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1237-6_19

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  • DOI: https://doi.org/10.1007/978-1-4613-1237-6_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8526-7

  • Online ISBN: 978-1-4613-1237-6

  • eBook Packages: Springer Book Archive

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