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Acute lymphocytic leukemia: a comprehensive review with emphasis on biology and therapy

  • Chapter
Molecular Genetics and Therapy of Leukemia

Part of the book series: Cancer Treatment and Research ((CTAR,volume 84))

Abstract

Acute lymphocytic leukemia (ALL) is a malignant hematologic disorder resulting from the clonal proliferation of lymphoid precursors with arrested maturation [1]. The disease can originate in lymphoid cells of different lineages, thus giving rise to B-cell or T-cell leukemias, or sometimes mixed lineage leukemia (see table 1). There are 3,000 to 5,000 new cases of ALL diagnosed every year in the United States [2,3]. In adults it represents 20% of all leukemias [4] and 1% to 2% of all cancers [5]. The disease has historic relevance, since it was one of the first malignancies reported to respond to chemotherapy [6] and was later among the first malignancies that could be cured in a majority of children [7]. Since then, much progress has been made, not only in terms of treatment for ALL but also, importantly, in understanding the heterogeneity of the disease. As information has accumulated about molecular aberrations, immunophenotyping, chromosomal abnormalities, and prognostic factors, more rational therapies have been designed. Since most cases are diagnosed in children [4], our current knowledge has originated from studies in the pediatric population. As differences between childhood and adult ALL became apparent, more research and progress has been made in adults.

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Authors
  1. Jorge E. Cortes
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  2. Hagop Kantarjian
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  3. Emil J. Freireich
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Editors and Affiliations

  1. Department of Hematology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Doulevard, Box 55, Houston, TX, 77030, USA

    Emil J. Freireich M.D.

  2. Department of Hematology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 61, Houston, TX, 77030, USA

    Hagop Kantarjian M.D.

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© 1996 Kluwer Academic Publishers, Boston

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Cortes, J.E., Kantarjian, H., Freireich, E.J. (1996). Acute lymphocytic leukemia: a comprehensive review with emphasis on biology and therapy. In: Freireich, E.J., Kantarjian, H. (eds) Molecular Genetics and Therapy of Leukemia. Cancer Treatment and Research, vol 84. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1261-1_13

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  • DOI: https://doi.org/10.1007/978-1-4613-1261-1_13

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