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Autocrine Growth Factors and Lung Cancer

  • Chapter
Basic and Clinical Concepts of Lung Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 45))

Abstract

Lung cancer is rapidly fatal in all but a small minority of patients regardless of therapy [1]. This situation reflects our inability to detect this disease prior to systemic dissemination, and the inadequacy of our systemic therapies for this disease [2]. The enormous investment of the National Cancer Institute and others in empiric new drug development has not had the same impact in lung cancer and other solid tumors as was seen in the hematologic malignancies. Both in response to the unfulfilling drug screening experience and to enhance understanding of tumor biology, many investigators are looking to more rationally developed anticancer therapies to lead to breakthroughs in the control of solid tumors. In lung cancer biology, there are many different directions that could be explored [3]. Recent developments in growth factor biology and the availability of specific antagonists that can be administered to patients, as is the case with monoclonal antibody [4], make this area especially promising. In this chapter we will review the development of growth factor research, attempting to summarize the current state of understanding of the role of growth factors especially as they relate to lung cancer, and discuss how that knowledge can be exploited for the successful therapy of lung cancer.

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Authors
  1. James L. Mulshine
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  2. Ronald B. Natale
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  3. Ingalill Avis
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  4. Anthony M. Treston
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  5. Philip G. Kasprzyk
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  6. Yoichi Nakanishi
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  7. Edward A. Sausville
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  8. Jane B. Trepel
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  9. Frank Cuttitta
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Editors and Affiliations

  1. The Finsen Institute, Rigshospitalet, 49 Strandboulevarden, DK-2100, Copenhagen, Denmark

    Heine H. Hansen

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© 1989 Kluwer Academic Publishers, Boston

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Mulshine, J.L. et al. (1989). Autocrine Growth Factors and Lung Cancer. In: Hansen, H.H. (eds) Basic and Clinical Concepts of Lung Cancer. Cancer Treatment and Research, vol 45. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1593-3_7

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  • DOI: https://doi.org/10.1007/978-1-4613-1593-3_7

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