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Synergistic Actions of Interferons and Tumor Necrosis Factor

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Clinical Aspects of Interferons

Part of the book series: Developments in Medical Virology ((DIMV,volume 4))

Abstract

Although the clinical application of interferons has resulted in some notable therapeutic successes, most common forms of cancer are proving to be resistant to interferon therapy. Failure of single-agent therapy with interferons in many neoplastic diseases has led to attempts to combine interferon with chemotherapeutic agents or with other cytokines. A cytokine widely considered as a potential anti-tumor agent is tumor necrosis factor (TNF). Although clinical trials with TNF have started only recently (1), various combinations of TNF and interferons have already been evaluated quite extensively in preclinical studies, both in tissue culture and in animals. Results of these studies will be reviewed in this article.

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Authors and Affiliations

  1. Department of Microbiology, New York University Medical Center, 550 First Avenue, New York, NY, 10016, USA

    R. Feinman & J. Vilček

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  1. R. Feinman
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  2. J. Vilček
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  1. The Weizmann Institute of Science, Israel

    Michel Revel

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© 1988 Kluwer Academic Publishers, Boston

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Feinman, R., Vilček, J. (1988). Synergistic Actions of Interferons and Tumor Necrosis Factor. In: Revel, M. (eds) Clinical Aspects of Interferons. Developments in Medical Virology, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1737-1_27

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  • DOI: https://doi.org/10.1007/978-1-4613-1737-1_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8977-7

  • Online ISBN: 978-1-4613-1737-1

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