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Oxidation of Methionine in Proteins of Isolated Rat Heart Myocytes and Tissue Slices by Neutrophil-Generated Oxygen Free Radicals

  • Chapter
Myocardial Ischemia

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 67))

Abstract

It is now well established that reperfusion of ischemic heart tissues initiates the production of oxygen free radicals which exacerbate the damage to the myocardium (1–3). While it is clear that a large portion of the oxygen free radicals is formed in damaged tissue by endogenous reactions such as the metabolism of xanthine and arachidonic atld (4,5), it now appears likely that a major source of these free radicals are the neutrophils which migrate into the damaged tissues during the inflammatory response (6–8). At the site of damage, these neutrophils can become activated and can secrete a variety of oxidants such as superoxide anion, hydrogen peroxide, and hypochlorous acid (9).

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References

  1. Hess, M.L. and Manson, N.H. J. Mol. Cell. Cardiol. 16: 969–985, 1984.

    Article  PubMed  CAS  Google Scholar 

  2. Thompson, J.A. and Hess, M.L. Prog. Cardiovascular Dis. 28: 449–462, 1986.

    Article  CAS  Google Scholar 

  3. McCord, J.M., Roy, R.S. and Schaffer, S.W. Adv. Myocardiology 5: 183–189, 1985.

    CAS  Google Scholar 

  4. Chambers, D.E., Parks, D.A., Patterson, G., Roy, R., McCord, J.M., Yoshida, S., Parmley, L.F. and Downey, J.M. J. Mol. Cell. Cardiol 17: 145–152, 1985.

    Article  PubMed  CAS  Google Scholar 

  5. Nastainczyk, W., Ullrich, V., Cadenas, E. and Sies, H. In: Oxygen Radicals in Chemistry and Biology, Walter de Gruyter & Co., Berlin, 1984, pp. 441–445.

    Google Scholar 

  6. Lucchesi, B.R., Romson, J.L. and Jolly, S.R. In: Therapeutic Approaches to Myocardial Infarct Size Limitation (Eds. D.J. Hearse and D.M. Yellon) Raven Press, New York, 1984, pp. 219–248.

    Google Scholar 

  7. Lucchesi, B.R. In: Prostaglandins and Other Eicosanoids in the Cardiovascular System (Ed. Schrör), Karger, Basel, 1985, pp. 160–171.

    Google Scholar 

  8. Lucchesi, B.R. and Mullane, K.M. Am. rev. Pharmacol. Toxicol. 26: 201–224, 1986.

    Article  CAS  Google Scholar 

  9. Weiss, S.J. and LoBuglio, A.F. Lab. Invest. 47: 5–18, 1982.

    PubMed  CAS  Google Scholar 

  10. Tauber, A.I. and Babior, B.M. Adv. Free Radical Biology & Medicine 1: 265–307, 1985.

    Article  CAS  Google Scholar 

  11. Pember, S.O., Shapira, R. and Kinkade, J.M. Jr. Arch. Biochem. Biophys. 221: 391–403, 1983.

    Article  CAS  Google Scholar 

  12. Winterbourn, C.C. Biochim. Biophys. Acta. 840: 204–210, 1985.

    Article  PubMed  CAS  Google Scholar 

  13. Ossanna, P.J., Test, S.T., Matheson, N.R., Regiani, S. and Weiss, S.J. J. Clin. Invest. 77: 1939–1951, 1986.

    Article  PubMed  CAS  Google Scholar 

  14. Brot, N. and Weissbach, H. Trend. Biochem. Sci. 7: 137–139, 1982.

    Article  CAS  Google Scholar 

  15. Brot, N. and Weissbach, H. Arch. Biochem. Biophys. 223: 271–281, 1983.

    Article  PubMed  CAS  Google Scholar 

  16. Fliss, H., Weissbach, H. and Brot, N. Proc. Natl. Acad. Sci. USA 80: 7160–7164, 1983.

    Article  PubMed  CAS  Google Scholar 

  17. Gross, E. Methods Enzymol. 11: 238–255, 1967.

    Article  CAS  Google Scholar 

  18. Hohl, C.M., Altschuld, R.A. and Brierley, G.P. Arch. Biochem. Biophys. 221: 197–205, 1983.

    Article  PubMed  CAS  Google Scholar 

  19. Farmer, B.B., Mancina, M., Williams, E.S. and Watanabe, A.M. Life Sci. 33: 1–18, 1983.

    Article  PubMed  CAS  Google Scholar 

  20. Grochowski, E.C., Ganote, C.E., Hill, M.L. and Jennings, R.B. J. Mol. Cell. Cardiol. 8: 173–187, 1976.

    Article  PubMed  CAS  Google Scholar 

  21. Boyum, A. Scand. J. Clin. Lab. Invest. 21(Suppl. 97): 77–89, 1968.

    CAS  Google Scholar 

  22. Calamai, E.G. and Spitznagel, J.K. Lab. Invest. 46: 597–604, 1982.

    PubMed  CAS  Google Scholar 

  23. Hodinka, R.L. and Modrzakowski, M.C. Infect. Immunity 40: 139–146 1983.

    CAS  Google Scholar 

  24. Brestel, E.P. Biochem. Biophys. Res. Commun. 126: 482–488, 1985.

    Article  PubMed  CAS  Google Scholar 

  25. Parish, C.R. and Stanley, P. Immunochemistry 9: 853–872, 1972.

    Article  PubMed  CAS  Google Scholar 

  26. Kikuchi, Y., Yamiya, N., Nozawa, T. and Hatanó, M. Eur. J. Biochem. 125: 575–577, 1982.

    Article  PubMed  CAS  Google Scholar 

  27. Sanchez, J., Nikolan, B.J. and Stumpf, P.K. Plant Physiol. 73: 619–623, 1983.

    Article  PubMed  CAS  Google Scholar 

  28. Halliwell, B. and Gutteridge, J.M.C. Free radicals in biology and medicine. Clarendon Press, Oxford, 1985.

    Google Scholar 

  29. Jones, D.P. In: Oxidative Stress (Ed. H. Sies) Academic Press, New York, 1985, pp. 151–195.

    Google Scholar 

  30. Flohé, L., Beckmann, R., Giertz, H., and Loschen, G. In: Oxidative Stress (Ed. H. Sies) Academic Press, New York, 1985, pp. 403–435.

    Google Scholar 

  31. Weiss, S.J., Lampert, M.B. and Test, S.T. Science 222: 625–628, 1983.

    Article  PubMed  CAS  Google Scholar 

  32. El-Hag, A., Lipsky, P.E., Bennett, M. and Clark, R.A. J. Immunol. 136: 3420–3426, 1986.

    PubMed  CAS  Google Scholar 

  33. Mullane, K.M., Kraemer, R. and Smith, B. J. Pharmacol. Methods 14: 157–167, 1985.

    Article  PubMed  CAS  Google Scholar 

  34. Clark, R.A. In: Adv. Inflammation Res., Vol 5, (Ed. G. Weissmann) Raven Press, New York, 1983, pp. 107–146.

    Google Scholar 

  35. Klebanoff, S.J. and Clark, R.A. The neutrophil: function and clinical disorders, Elsevier-North Holland, Amsterdam, 1978.

    Google Scholar 

  36. Hess, M.L., Rowe, G.T., Caplan, M., Romson, J.L, and Lucchesi, B. In: Adv. myocardiology, vol 5 (Eds. P. Harris and P.A. Poole-Wilson) Plenum, New York, 1985, pp. 159–175.

    Google Scholar 

  37. Green, T.R., Fellman, J.H. and Eicher, A.L. FEBS Lett. 192: 33–36, 1985.

    Article  PubMed  CAS  Google Scholar 

  38. Britigan, B.E., Rosen, G.M., Chai, Y. and Cohen, M.S. J. Biol. Chem. 261: 4426–4431, 1986.

    PubMed  CAS  Google Scholar 

  39. Hammond, B., Kontos, H.A. and Hess, M.L. Can. J. Physiol. Pharmacol. 63: 173–187, 1985.

    Article  PubMed  CAS  Google Scholar 

  40. Johnson, K.J., Fantone, J.C. III, Kaplan, J. and Ward, P.A. J. Clin. Invest. 67: 983–993, 1981.

    Article  PubMed  CAS  Google Scholar 

  41. Mullane, K.M., Read, N., Salmon, J.A. and Moncada, S. J. Pharmacol. Exp. Ther. 228: 510–522, 1984.

    PubMed  CAS  Google Scholar 

  42. Engler, R.L., Dahlgren, M.D., Peterson, M.A., Dobbs, A. and Schmid-Schönbein, G.W. Am. J. Physiol. 251: H93-H100, 1986.

    PubMed  CAS  Google Scholar 

  43. Romson, J.L., Hook, B.G., Kunkel, S.L., Abrams, G.D., Schork, M.A. and Lucchesi, B.R. Circulation 67: 1016–1023, 1983.

    Article  PubMed  CAS  Google Scholar 

  44. Sepe, S.M. and Clark, R.A. J. Immunol. 134: 1888–1895, 1985.

    PubMed  CAS  Google Scholar 

  45. Piper, H.M., Spahr, R., Hutter, J.F. and Spieckermann, P.G. Basic Res. Cardiol, 80(Suppl. 2): 159–163, 1985.

    PubMed  Google Scholar 

  46. Severns, C., Collins-Lech, C. and Sohnle, P.G. J. Lab. Clin. Med. 107: 29–35, 1986.

    PubMed  CAS  Google Scholar 

  47. Ushijima, Y. and Nakano, M. Biochem. Biophys. Res. Commun. 93: 1232–1237, 1980.

    Article  PubMed  CAS  Google Scholar 

  48. Cuperns, R.A., Muijsers, A.O. and Wever, R. Arthritis Rheumatism 28: 1228–1233, 1985.

    Article  Google Scholar 

  49. Matheson, N.R. and Travis, J. Biochemistry 24: 1941–1945, 1985.

    Article  PubMed  CAS  Google Scholar 

  50. Tsan, M.-F. and Chen, J.W. J. Clin. Invest. 65: 1041–1050, 1980.

    Article  PubMed  CAS  Google Scholar 

  51. Clark, R.A. J. Immunol. 136: 4617–4622, 1986.

    PubMed  CAS  Google Scholar 

  52. Zimmerli, W., Lew, P.D., Cohen, H.J. and Waldvogel, F.A. Infect. Immunity 46: 625–630, 1984.

    CAS  Google Scholar 

  53. Walsh, M. and Stevens, T.C. Biochemistry 16: 2742–2749, 1977.

    Article  PubMed  CAS  Google Scholar 

  54. Walsh, M. and Stevens, T.C. Biochemistry 16: 3924–3930, 1977.

    Article  Google Scholar 

  55. Babu, Y.S., Sack, J.S., Greenhough, T.J., Bugg, C.E., Means, A.R. and Cook, W.J. Nature 315: 37–40, 1985.

    Article  PubMed  CAS  Google Scholar 

  56. Tobler, P.H., Tschopp, F.A., Dambacher, M.A., Born, W. and Fischer, J.A. J. Clin. Endocrinol. Metab. 57: 749–754, 1983.

    Article  PubMed  CAS  Google Scholar 

  57. Frelinger, A.L. and Zull, J.E. J. Biol. Chem. 259: 5507–5513, 1984.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, Faculty of Health Sciences, University of Ottawa, 451 Smyth Road, K1H 8M5, Ottawa, Ontario, Canada

    H. Fliss & G. Docherty

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  1. H. Fliss
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  2. G. Docherty
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Editors and Affiliations

  1. Youville Research Institute, St. Boniface General Hospital, and Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla , Ian R. Innes  & Robert E. Beamish ,  & 

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Fliss, H., Docherty, G. (1987). Oxidation of Methionine in Proteins of Isolated Rat Heart Myocytes and Tissue Slices by Neutrophil-Generated Oxygen Free Radicals. In: Dhalla, N.S., Innes, I.R., Beamish, R.E. (eds) Myocardial Ischemia. Developments in Cardiovascular Medicine, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2055-5_7

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  • DOI: https://doi.org/10.1007/978-1-4613-2055-5_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9221-0

  • Online ISBN: 978-1-4613-2055-5

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