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Senile Systemic Amyloidosis

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Amyloidosis

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Abstract

Senile systemic amyloid contains the prealbumin-like fibril protein, ASc1, and is the only known form of systemic age-related amyloid. Although it involves predominantly the heart, it may be found in a wide range of tissues. Immunologic studies show that ASc1 cross reacts with human prealbumin (PA) in binding reactions but not in immunoprecipitation reactions. Protein ASc1 shows complete homology with PA in four residues isolated. However, unlike PA, Asc1 may have a blocked N-terminus and is composed of at least three components. Anti-ASc1 forms a line of precipitation with sera from patients with familial amyloidosis. A similar weak reaction has been observed in some elderly patients with senile systemic amyloid.

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References and Notes

  1. P. Westermark, J. B. Natvig, B. Johansson, J. Exp. Med., 146:631 (1977).

    Article  PubMed  CAS  Google Scholar 

  2. K. Sletten, P. Westermark, J. B. Natvig, Scand. J. Immunol., 12:503 (1980).

    Article  PubMed  CAS  Google Scholar 

  3. G. G. Cornwell III, P. Westermark, J. B. Natvig, W. Murdoch, Immunology, 44:447 (1981).

    PubMed  CAS  Google Scholar 

  4. G. G. Cornwell III, W. L. Murdoch, R. A. Kyle, P. Westermark, P. Pitkanen, Am. J. Med., 75:618 (1983).

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  5. P. Pitkanen, P. Westermark, G. G. Cornwell III, Am. J. Path, (in press).

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  6. P. Felding, G. Fex, P. Westermark, B.-O. Olofsson, P. Pitkanen, L. Benson, Scand. J. Immun. (in press).

    Google Scholar 

  7. P. Westermark, P. Pitkanen, L. Benson, A. Vahlquist, B-0. Olofsson, G. G. Cornwell III, Lab. Invest, (in press).

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  8. Supported in part by the Swedish Medical Research Council (Project No. 5941) and the Research Fund of King Gustaf V.

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Authors and Affiliations

  1. Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire, USA

    G. G. Cornwell III, P. Westermark, R. A. Kyle, P. Pitkanen, L. Benson & B.-O. Olofsson

  2. Department of Pathology, University Hospital, Uppsala, Sweden

    G. G. Cornwell III, P. Westermark, R. A. Kyle, P. Pitkanen, L. Benson & B.-O. Olofsson

  3. Department of Clinical Chemistry, University Hospital, Uppsala, Sweden

    G. G. Cornwell III, P. Westermark, R. A. Kyle, P. Pitkanen, L. Benson & B.-O. Olofsson

  4. Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA

    G. G. Cornwell III, P. Westermark, R. A. Kyle, P. Pitkanen, L. Benson & B.-O. Olofsson

  5. Department of Medicine, University Hospital, Umea, Sweden

    G. G. Cornwell III, P. Westermark, R. A. Kyle, P. Pitkanen, L. Benson & B.-O. Olofsson

Authors
  1. G. G. Cornwell III
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  2. P. Westermark
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  3. R. A. Kyle
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  4. P. Pitkanen
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  5. L. Benson
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  6. B.-O. Olofsson
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Editor information

Editors and Affiliations

  1. University of California, San Diego La Jolla, California, USA

    George G. Glenner

  2. Columbia University, New York, New York, USA

    Elliott F. Osserman

  3. University of Washington, Seattle, Washington, USA

    Earl P. Benditt

  4. State University of New York at Buffalo, Buffalo, New York, USA

    Evan Calkins

  5. Boston University School of Medicine, Boston, Massachusetts, USA

    Alan S. Cohen

  6. New York University School of Medicine, New York, New York, USA

    Dorothea Zucker-Franklin

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© 1986 Plenum Press, New York

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Cornwell, G.G., Westermark, P., Kyle, R.A., Pitkanen, P., Benson, L., Olofsson, BO. (1986). Senile Systemic Amyloidosis. In: Glenner, G.G., Osserman, E.F., Benditt, E.P., Calkins, E., Cohen, A.S., Zucker-Franklin, D. (eds) Amyloidosis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2199-6_83

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  • DOI: https://doi.org/10.1007/978-1-4613-2199-6_83

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9292-0

  • Online ISBN: 978-1-4613-2199-6

  • eBook Packages: Springer Book Archive

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