Abstract
The distribution of DNA synthesizing and/or dividing non-neuronal cells is unequal within the brain and meningeal envelopes of mice at different ages. In addition to large scale regional differences, a focal occurrence of labeled cells (LC) has been demonstrated in the subependymal layer and in the brain parenchyma; the latter is attributed to the presence of “stem” cells or their transiently activated dormant forms. The number of LC decreases during adulthood, but not equally in all brain regions. In the periventricular subependymal layer of the forebrain, the decrease is relatively less profound than in the main mass of the brain. A certain number of cells synthesizing DNA is still present in all regions of the mouse brain till early senescence. A substantial part of the newly-formed cells, or their DNA, undergoes disintegration, soon after their origin or synthesis.
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© 1986 Martinus Nijhoff Publishing
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Mareš, V. (1986). DNA Synthesis and Cell Number Homeostasis in the Brain. In: Giuditta, A., Kaplan, B.B., Zomzely-Neurath, C. (eds) Role of RNA and DNA in Brain Function. Topics in the Neurosciences, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2321-1_21
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DOI: https://doi.org/10.1007/978-1-4613-2321-1_21
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