Abstract
The nerve cell adhesion molecule (N-CAM) is a surface glycoprotein and the most extensively characterized cell adhesion molecule of the nervous system (1,2). It is composed of a triplet of transmembrane oriented, glycosylated peptides. Developmentally regulated modifications in its sugar content have been described. The embryonic, highly sialylated form, migrates in polyacrylamide gel electrophoresis as a diffuse band in the MW range of 200 to 250 kD. In adult animals, on the contrary, a triplet of 180, 140 and 120 kD polypeptides is found (3). These biochemical changes are related to corresponding modifications of he functional properties: adult N-CAM displays an adhesive behavior which is not shared by embryonic N-CAM (4).
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References
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© 1986 Martinus Nijhoff Publishing
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Gennarini, G., Hirsch, M.R., Hirn, M., Goridis, C. (1986). Molecular Genetics of the Nerve Cell Adhesion Molecule N-Cam: Evidence for Multiple, Developmentally Regulated, mRNA Species. In: Giuditta, A., Kaplan, B.B., Zomzely-Neurath, C. (eds) Role of RNA and DNA in Brain Function. Topics in the Neurosciences, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2321-1_25
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DOI: https://doi.org/10.1007/978-1-4613-2321-1_25
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