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Barbiturate and Opiate Actions on Calcium-Dependent Action Potentials and Currents of Mouse Neurons in Cell Culture

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Calcium in Biological Systems

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Abstract

The purpose of this chapter is to consider the actions of depressant drugs on calcium entry into neurons. Since presynaptic calcium entry is an essential link in excitation-secretion coupling of synaptic transmission, a reduction of calcium entry by depressant drugs should produce a reduction in neurotransmitter release and therefore a reduction in synaptic transmission. In this chapter we will review evidence obtained by using intracellular recordings from mouse neurons in primary dissociated cell culture which indicates that barbiturate and opiate drugs reduce presynaptic calcium entry. Evidence will also be presented which suggest that there are substantial differences in the manner in which these two drug classes modify calcium movement.

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Authors and Affiliations

  1. Departments of Neurology and Physiology, University of Michigan, Ann Arbor, Michigan, 48109, USA

    Robert L. MacDonald & Mary Ann Werz

Authors
  1. Robert L. MacDonald
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  2. Mary Ann Werz
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Editors and Affiliations

  1. Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA

    Ronald P. Rubin  & James W. Putney Jr.  & 

  2. CIBA-GEIGY Corporation, Summit, New Jersey, USA

    George B. Weiss

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© 1985 Plenum Press, New York

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MacDonald, R.L., Werz, M.A. (1985). Barbiturate and Opiate Actions on Calcium-Dependent Action Potentials and Currents of Mouse Neurons in Cell Culture. In: Rubin, R.P., Weiss, G.B., Putney, J.W. (eds) Calcium in Biological Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2377-8_27

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  • DOI: https://doi.org/10.1007/978-1-4613-2377-8_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9453-5

  • Online ISBN: 978-1-4613-2377-8

  • eBook Packages: Springer Book Archive

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