Skip to main content

Melt Spinning of Poly-L-Lactide and Hydrolysis of the Fiber in Vitro

  • Chapter
Polymers as Biomaterials

Abstract

It has been widely recognized that biocompatibility of a polymeric material is the minimal requisite for use as a surgical implant. What we mean by the biocompatibility is different from one implant to another, depending on the purpose and the duration of implantation. For instance, nonthrombogenicity is required for the material to be used as a small vascular graft, while strong bioadhesion with host tissues is needed if the polymer is used for artificial tracheas. On the other hand, soft biomaterials are often demanded which give no mechanical stimulus to the surrounding tissue, as IUD and contact lens. The biocompatibility involves all of these properties, implying that it is difficult to give a clear single definition to the term “biocompatibility”.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. L.L. Hench, Science, 208, 826 (1980).

    Article  CAS  Google Scholar 

  2. R.L. Kronenthal in “Polymers in Medicine and Surgery”, R.L. Kronenthal, Z. Oser, and E. Martin, Eds., Plenum Press New York, 1975, p. 119.

    Google Scholar 

  3. M. Vert, F. Chabot, J. Leray, and P. Christel, Makromol. Chem., Suppl. 5, 30 (1981).

    Article  CAS  Google Scholar 

  4. A.S. Hoffman, J. Appl. Polym. Sci. Appl. Polym. Symp., 31, 313 (1977).

    CAS  Google Scholar 

  5. E.W. Fischer, H.J. Sterzel, and G. Wegner, Kolloid-Z.u.Z Polymere, 251, 980 (1973).

    Article  CAS  Google Scholar 

  6. B. Kalb and A.J. Pennings, Polymer, 21, 607 (1980).

    Article  CAS  Google Scholar 

  7. R. Vasanthakumari and A.J. Pennings, Polymer, 24, 175 (1983).

    Article  CAS  Google Scholar 

  8. F. Chabot, M. Vert, S. Chapelle, and P. Granger, Polymer, 24, 53 (1983).

    Article  CAS  Google Scholar 

  9. C.V. Prasad and K. Sundram, Int. J. Quantum Chem., 20, 613 (1981).

    Article  CAS  Google Scholar 

  10. R.J.M. Zwiers, S. Gogolewski, and A.J. Pennings, Polymer, 24, 167 (1983).

    Article  CAS  Google Scholar 

  11. P.D. Santis and A.J. Kovacs, Biopolymers, 6, 299 (1968).

    Article  Google Scholar 

  12. B. Eling, S. Gogolewski, and A.J. Pennings, Polymer, 23, 1587 (1982).

    Article  CAS  Google Scholar 

  13. L. Sedel, F. Chabot, P. Christel, X.d. Charentenay, J. Leray, and M. Vert, Rev. Chir. Orthop., 64Suppl. II, 92 (1978).

    Google Scholar 

  14. Y.M. Trehu (Ethicon, Inc.), U.S.P. 3,531, 561 (1970).

    Google Scholar 

  15. A.K. Schneider (Ethicon, Inc.), U.S.P. 3,636, 956 (1972).

    Google Scholar 

  16. C.E. Lowe (E.I. du Pont de Nemours & Co., Inc.), U.S.P. 2,668, 162 (1954).

    Google Scholar 

  17. O. Wasserman and C.C. Versfelt (Ethicon, Inc.), U.S.P. 3, 839, 297 (1974).

    Google Scholar 

  18. A. Schindler and D. Harper, J. Polym. Sci., Polym. Chem. Ed., 17, 2593 (1979).

    Article  CAS  Google Scholar 

  19. C.C. Chu, J. Appl. Polym. Sci., 26, 1727 (1981).

    Article  CAS  Google Scholar 

  20. C.C. Chu and N.D. Campbell, J. Biomed. Mater. Res., 16, 417 (1982).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Plenum Press, New York

About this chapter

Cite this chapter

Hyon, SH., Jamshidi, K., Ikada, Y. (1984). Melt Spinning of Poly-L-Lactide and Hydrolysis of the Fiber in Vitro. In: Shalaby, S.W., Hoffman, A.S., Ratner, B.D., Horbett, T.A. (eds) Polymers as Biomaterials. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2433-1_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2433-1_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9480-1

  • Online ISBN: 978-1-4613-2433-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics