Abstract
In a population study of leukocytes from 140 human subjects, far UV-induced unscheduled DNA synthesis (UDS) variation correlated with at least three demographic factors — smoking tobacco, season of sample obtainment and “street opiate” addiction. The ability to correlate UDS variability with these factors demonstrates the importance of environmental influences in control of DNA repair processes and the need to include the effect of demographics in genetic risk assessment models. In addition, mutagen-induced UDS patterns for mononuclear leukocytes from a single subject did not match the UDS pattern for fibroblasts grown from a forearm skin biopsy from the same individual which suggests that UDS may be tissue specific.
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© 1985 Plenum Press, New York
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Madden, J.J. et al. (1985). Influence of Demographic Factors on Scheduled DNA Synthesis as Measured in Human Peripheral Leukocytes and Fibroblasts. In: de Serres, F.J., Pero, R.W. (eds) Individual Susceptibility to Genotoxic Agents in the Human Population. Environmental Science Research, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2765-3_23
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DOI: https://doi.org/10.1007/978-1-4613-2765-3_23
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