Abstract
Administration of the acetylcholinesterase inhibitor physostigmine to man produces a range of behavioral changes that can be of therapeutic benefit to some patients with Huntington’s disease, tardive dyskinesia, mania and memory deficits (Aquilonius and Sjostrom, 1971; Janowsky et al, 1973; Klawans and Rubovits, 1974; Davis et al., 1976; 1978a; 1978b). The scope and complexity of the actions of physostigmine suggest that the neurochemical basis of these effects might extend beyond the ability of the drug to increase cholinergic activity. It is possible that some of the behavioral consequences of physostigmine result from the action of increased central cholinergic activity on other neurotransmitters.
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Davis, K.L., Faull, K.F., Hollister, L.E., Barchas, J.D., Berger, P.A. (1979). Physostigmine Related Changes in Cerebrospinal Fluid Neurotransmitter Metabolites in Man. In: Davis, K.L., Berger, P.A. (eds) Brain Acetylcholine and Neuropsychiatric Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2934-3_25
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DOI: https://doi.org/10.1007/978-1-4613-2934-3_25
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