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Classical Conditioning, Drug Tolerance, and Drug Dependence

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Research Advances in Alcohol and Drug Problems

Part of the book series: Research Advances in Alcohol and Drug Problems ((AADP,volume 7))

Abstract

Most theories of drug tolerance and dependence stress the physiological consequences of repeated pharmacological stimulation. There is considerable evidence, however, that the organism’s experience with the drug administration environment, as well as the drug, often importantly contributes to tolerance and dependence. The role of such environmental cues has been elaborated in a model which emphasizes Pavlovian conditioning principles. This account is based on the work of a number of investigators, but primarily Wikler (e.g., 1973, 1977, 1980), who have stressed the contribution of pharmacological learning to drug effects. This chapter describes the conditioning theory of tolerance, summarizes the data which supports the theory, discusses the relevance of the theory to drug dependence, and presents the implications ofthe theory for the treatment of drug abuse. Since some of the material has been summarized previously (Hinson and Siegel, 1980; Siegel, 1978a, 1979 b), this chapter emphasizes developments subsequent to earlier reviews.

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References

  • Abelson, P. H., 1970, Death from heroin, Science 168 :1289.

    Google Scholar 

  • Adam, G., 1967, Interoception and Behavior, Publishing House of the Hungarian Academy of Sciences, Budapest.

    Google Scholar 

  • Adams, W. J., Yeh, S. Y., Woods, L. A., and Mitchell, C. L., 1969, Drug-test interaction as a factor in the development of tolerance to the analgesic effect of morphine, J. Pharmacol. Exp. Ther. 168 :251.

    Google Scholar 

  • Advokat, C., 1980, Evidence for conditioned tolerance of the tail flick reflex, Behav. Neur. Bioi. 29: 385.

    Google Scholar 

  • Blakey, R., and Baker, R., 1980, An exposure approach to alcohol abuse, Behav. Res. Ther. 18 :319.

    Google Scholar 

  • Bourne, L. J. Jr., and Ekstrand, B. R., 1979, Psychology: Its Principles and Meanings, Holt, Rinehart and Winston, New York.

    Google Scholar 

  • Bower, G. H., 1981, Mood and memory, Am. Psychol. 36 :129.

    Google Scholar 

  • Brecher, E. M., 1972, Licit and Illicit Drugs, Little, Brown, Boston.

    Google Scholar 

  • Bykov, K. M., 1959, The Cerebral Cortex and the Internal Organs, Foreign Languages, Moscow.

    Google Scholar 

  • Cappell, H., and leBlanc, A. E., 1981, Tolerance and physical dependence: Do they playa role in alcohol and drug self-administration? in: Research Advances in Alcohol and Drug Problems Vol. 6 (Y. Israel, F. Glaser, H. Kalant, R. E. Popham, W. Schmidt, and R. G. Smart, eds.), Plenum Press, New York.

    Google Scholar 

  • Cappell, H., Roach, C., and Poulos, C. X., 1981, Pavlovian control of cross-tolerance between pentobarbital and ethanol, Psychopharmacology 74 :54.

    Google Scholar 

  • Cherubin, C., McCusker, J., Baden, M., Kavaler, F., and Amsel, Z., 1972, The epidemiology of death in narcotic addicts, Am. J. Epidemiol. 96 :11.

    Google Scholar 

  • Clark, W. G., and Clark, Y. L., 1980, Changes in body temperature after administration of acetylcholine, histamine, morphine, prostaglandins and related agents. Neurosci. Biobehav. Rev. 4: 175.

    Google Scholar 

  • Cochin, J., 1972, Some aspects of tolerance to the narcotic analgesics, in: Drug Addition 1. Experimental Pharmacology ( J. M. Singh, L. Miller, and H. S. Lal, eds.), pp. 365–375, Futura, New York.

    Google Scholar 

  • Cochin, J., and Kornetsky, C., 1964, Development and loss of tolerance to morphine in the rat after single and multiple injections, J. Pharmacol. Exp. Ther. 145 :1.

    Google Scholar 

  • Cohen, M., Keats, A. S. Krivoy, W., and Ungar, G., 1965, Effect of actinomycin D on morphine tolerance, Proc. Soc. Exp. Bioi. Med. 119 :381.

    Google Scholar 

  • Collins, W., 1966, The Moonstone, Penguin Books, Harmondsworth, England (Originally published in 1868 ).

    Google Scholar 

  • Crowell, C. R., Hinson, R. E., and Siegel, S., 1981, The role of conditional drug responses in tolerance to the hypothermic effect of ethanol, Psychopharmacology 73 :51.

    Google Scholar 

  • Deutsch, R., 1974, Conditioned hypoglycemia: A mechanism for saccharin-induced sensitivity to insulin in the rat, J. Compo Physiol. Psychol. 86 :350.

    Google Scholar 

  • Dews, P. B., 1962, Psychopharmacology, in: Experimental Foundations of Clinical Psychology (A. I. Bachrach, ed.), pp. 423 - 441, Basic Books, New York.

    Google Scholar 

  • Domjan, M., and Burkhard, B., 1982, The Principles 0/ Learning and Behavior, Brooks/Cole, Monterey, California.

    Google Scholar 

  • Domjan, M., and Gillan, D. J., 1977, Aftereffects of lithium-conditioned stimuli on consummatory behavior, J. Exp. Psychol: Anim. Behav. Proc., 3 :322.

    Google Scholar 

  • Duberstein, J. L., and Kaufman, D. M., 1971, A clinical study of an epidemic of heroin intoxication and heroin-induced pulmonary edema, Am. J. Med. 51 :704.

    Google Scholar 

  • Eikelboom, R., and Stewart, J., 1979, Conditioned temperature effects using morphine as the unconditioned stimulus, Psychopharmacology 61 :31.

    Google Scholar 

  • Eikelboom, R., and Stewart, J., 1981, Temporal and environmental cues in conditioned hypothennia and hypertbennia associated with morphine, Psychopharmacology 72 :147.

    Google Scholar 

  • Fennessy, M. R., and Lee, J. R., 1975, The assessment of and the problems involved in the experimental evaluation of narcotic analgesics, in: Methods in Narcotics Research (S. Ehrenpreis and A. Neidle, eds.), pp. 73– 99, Marcel Dekker, New York.

    Google Scholar 

  • Ferguson, R. K., and Mitchell, C. L., 1969, Pain as a factor in the development of tolerance to morphine analgesia in man, Clin. Pharmacol. Ther. 10 :372.

    Google Scholar 

  • Foxx, R. M., and Brown, R. A., 1979, Nicotine fading and self-monitoring for cigarette abstinence or controlled smoking, J. Appl. Behav. Anal. 12 :111.

    Google Scholar 

  • Fulmer, R. H., and Lapidus, L. B., 1980, A study of professed reasons for beginning and continuing heroin use, Int. J. Addict. 15 :631.

    Google Scholar 

  • Ginsburg, M., and Cox, B. M., 1972, Proteins and nucleic acids, in: Chemical and Biological Aspects of Drug Dependence (S. J. Mule and H. Brill, eds.), pp. 465–475, CRC Press, Cleveland.

    Google Scholar 

  • Goldberg, S. R., and Schuster, C. R., 1967, Conditioned suppression by a stimulus associated with nalorphine in morphine-dependent monkeys, J. Exp. Anal. Behav. 10 :235.

    Google Scholar 

  • Goldberg, S. R., and Schuster, C. R., 1970, Conditioned nalorphine-induced abstinence changes: Persistence in post morphine-dependent monkeys, J. Exp. Anal. Behav. 14 :33.

    Google Scholar 

  • Goldstein, D. B., and Pal, N., 1971, Alcohol dependence produced in mice by inhalation of ethanol: Grading the withdrawal reaction, Science 172 :288.

    Google Scholar 

  • Government of Canada, 1973, Final Report of the Commission 0/ Inquiry Into the Nonmedical Use of Drugs. Infonnation Canada. Ottawa. Ontario.

    Google Scholar 

  • Grabowski, J., and O’Brien, C. B., 1982, Conditioning factors in opiate use, in Advances in Substance Abuse Vol. 2 (N. Mello, ed.), JAI Press, Greenwich, Connecticut.

    Google Scholar 

  • Greeley, J. D., 1981, “Conditioning and Tolerance to Chlordiazepoxide.“ unpublished M. A. thesis, University of Toronto.

    Google Scholar 

  • Greene, M. H., Luke, J. L., and Dupont, R. L.. 1974. Opiate “overdose” deaths in the District of Columbia I. Heroin-related fatalities, Med. Ann. District o/Columbia 43 :175.

    Google Scholar 

  • Griffiths, R. R., Bigelow, G. E., and Henningfield, I. E., 1980, Similarities in animal and human drug-taking behavior, in: Advances in Substance Abuse: Behavioral and Biological Research (N. K. Mello, ed.), pp. 1-90, JAI Press, Greenwich, Connecticut.

    Google Scholar 

  • Guha, D., Dutta, S. N., and Pradham, S. N., 1974, Conditioning of gastric secretion by epinephrine in rats, Proc. Soc. Exp. Bioi. Med. 147 :817.

    Google Scholar 

  • Harvey. J. G., 1981, Drug-related mortality in an inner city area, Drug Ale. Dep. 7 :239.

    Google Scholar 

  • Hecht, T., Baumann, R., and Hecht, K., 1967, The somatic and vegetative regulatory behavior of the healthy organism during conditioning of the insulin effect, Condo Reflex 2 :96.

    Google Scholar 

  • Helpern, M., 1972, Fatalities from narcotic addiction in New York City: Incidence, circumstances, and pathologic findings, Hum. Pathol. 3 :13.

    Google Scholar 

  • Helzer, J. E., Robins, L. N., and Davis, D. H., 1975176, Antecedents of narcotic use and addiction: A study of 898 Vietnam veterans, Drug Alcohol Dep. 1:183.

    Google Scholar 

  • Himmelsbach, C. K., 1943, Symposium: Can the euphoric, analgetic and physical dependence effects of drugs be separated? IV. With reference to physical dependence, Fed. Proc. 2 :201.

    Google Scholar 

  • Hinson, R. E., and Siegel, S., 1980, The contribution of Pavlovian conditioning to ethanol tolerance and dependence, in: Alcohol Tolerance, Dependence, and Addiction ( H. Rigter and J. C. Crabbe, Jr., eds.), pp. 181–199, Elsevier/North-Holland Biomedical Press, Amsterdam.

    Google Scholar 

  • Hinson, R. E., and Siegel, S., 1982, Nonpharmacological bases of drug tolerance and dependence,

    Google Scholar 

  • J. Psychosom. Res., 26:495.

    Google Scholar 

  • Hinson, R. E., Poulos, C. X., and Cappell, H., 1982, The effects of pentobarbital and cocaine in rats expecting pentobarbital, Pharmacol. Biochem. Behav. 16 :661.

    Google Scholar 

  • Hodgson, R., 1980, Review of “Behavioural Tolerance: Research and Treatment Implications,” Br. J. Addict. 75 :101.

    Google Scholar 

  • Hodgson, R. J., and Rankin, H. J., 1976, Modification of excessive drinking by cue exposure, Behav. Res. Ther. 14 :305.

    Google Scholar 

  • Huber, D. H., 1974, Heroin deaths-Mystery or overdose? J. Am. Med. Assoc. 229 :689.

    Google Scholar 

  • Hug, C. C., 1972, Characteristics and theories related to acute and chronic tolerance development, in: Chemical and Biological Aspects of Drug Dependence ( S. J. Mule and H. Brill, eds.), pp. 307–358, CRC Press, Cleveland.

    Google Scholar 

  • Hunt, W. A., Barnett, L. W., and Branch, L. G., 1971, Relapse rates in addiction programs, J. c/in. Psychol. 27 :455.

    Google Scholar 

  • Jaffe, J. H., 1980, Drug addiction and drug abuse, in: The Pharmacological Basis of Therapeutics, 6th ed. ( A. S. Goodman, L. S. Goodman, and A. Gilman, eds.), pp. 535–584, Macmillan, New York.

    Google Scholar 

  • Jaffe, J. H., and Martin, W. R., 1980, Narcotic analgesics and antagonists, in: The Pharmacological Basis of Therapeutics, 6th ed. ( A. S. Goodman, L. S. Goodman, and A. Gilman, eds.), pp. 494–534, Macmillan, New York.

    Google Scholar 

  • Jones, B. M., 1974, Circadian variation in the effects of alcohol on cognitive performance, Q. J. Stud. Alcohol 35 :1212.

    Google Scholar 

  • Kalant, H., 1977, Comparative aspects of tolerance to, and dependence on, alcohol, barbiturates, and opiates, in: Alcohol Intoxication and Withdrawal-lllb: Studies in Alcohol Dependence ( M. Gross, ed.), pp. 57 - 64, Plenum Press, New York.

    Google Scholar 

  • Kalant, H., leBlanc, A. E., and Gibbins, R. J., 1971, Tolerance to, and dependence on, some non-opiate psychotropic drugs, Pharmacol. Rev. 23 :135.

    Google Scholar 

  • Kesner, R. P., and Baker, T. B., 1981, A two-process model of opiate tolerance, in: Endogenous Peptides, Learning and Memory Processes (J. Martinez, J. L., Jensen, R. R., Messing, H. E.

    Google Scholar 

  • Rigter, and 1. L. McGaugh, eds.), pp. 479–518, Academic Press, New York.

    Google Scholar 

  • Kesner, R. P., Priano, D. J., and DeWitt, J. R., 1976, Time-dependent disruption of morphine tolerance by electroconvulsive shock and frontal cortical stimulation, Science 194 :1079.

    Google Scholar 

  • Khanna, J. M., Le, A. D., Kalant, H., and leBlanc, A. E., 1979, Cross-tolerance between ethanol and morphine with respect to their hypothermic effects, Eur. J. Pharmacol. 59 :145.

    Google Scholar 

  • Kimble, G., 1961, Hilgard and Marquis' Conditioning and Learning, Appleton-Century-Crofts, New York.

    Google Scholar 

  • Kornetsky, C., and Bain G., 1968, Morphine: Single-dose tolerance, Science 162 :1011.

    Google Scholar 

  • Korol, B., and Mclaughlin, L. J., 1976, A homeostatic adaptive response to alpha-methyl-dopa in conscious dogs, Pavlovian J. Bioi. Sci. 11 :67.

    Google Scholar 

  • Korol, B., Sletten, I. W., and Brown, M. L., 1966, Conditioned physiological adaptation to anticholinergic drugs, Am. J. Physiol. 211 :911.

    Google Scholar 

  • Kraft, T., 1970, Treatment of Drinamyl addiction: Two case studies, J. Nerv. Ment. Dis. 150 :138.

    Google Scholar 

  • Krank, M. D., Hinson, R. E., and Siegel, S., 1981, Conditional hyperalgesia is elicited by environmental signals of morphine, Behav. Neur. Bioi. 32 :148.

    Google Scholar 

  • Krivoy, W. A., Zimmermann, E., and Lande, S., 1974, Facilitation of development of resistance to morphine analgesia by Desglycinamide9-Lysine Vasopressin, Proc. Natl. Acad. Sci. 71: 1852.

    Google Scholar 

  • Krylov, V., 1933, Additional data on the study of conditioned reflexes on chemical stimuli, Bioi. Abstr. 7 :871.

    Google Scholar 

  • LaHoste, G. J., Olson, R. D., Olson, G. A., and Kastin, A. J., 1980, Effects of Pavlovianconditioning and MIF-I on the development of morphine tolerance in rats, PhaT TUlcol. Biochem. Behav. 13 :799.

    Google Scholar 

  • Le, A. D., Poulos, C. X., and Cappell, H., 1979, Conditioned tolerance to the hypothennic effect of ethyl alcohol, Science 206 :1109.

    Google Scholar 

  • leBlanc, A. E., Matsunaga, M., and Kalant, H., 1976, Effects of frontal polar cortical ablation and cycloheximide on ethanol tolerance in rats, PhaT TUlcol. Biochem. Behav. 4 :175.

    Google Scholar 

  • leBlanc, A. E., Poulos, C. X., and Cappell, H. D., 1978, Tolerance as a behavioral phenomenon: Evidence from two experimental paradigms, in: Behavioral Tolerance: Research and Treatment Implications, National Institute on Drug Abuse Research Monograph No. 18; U. S. Department

    Google Scholar 

  • of Health, Education, and Welfare Publication No. [ADM] 78-551, (N. A. Krasnegor, ed.), pp. 72-79, U. S. Government Printing Office, Washington, D. C.

    Google Scholar 

  • Lesser, E., 1967, Behavior therapy with a narcotics user: A case report, Behav. Res. Ther. 5 :251.

    Google Scholar 

  • Lightfoot, L. 0.,1980, Behavioral Tolerance to Low Doses of Alcohol in Social Drinkers, unpublished Ph.D. thesis, Waterloo University.

    Google Scholar 

  • Louria, D. B., Hensle, T., and Rose, J., 1967, The major medical complications of heroin addiction, Ann. Intern. Med. 67 :1.

    Google Scholar 

  • Lubow, R. E., 1973, Latent inhibition, Psychol. Bull. 79 :398.

    Google Scholar 

  • Ludwig, A. M., and Stark, L. H., 1974, Alcohol craving: Subjective and situational aspects, Q. J. Stud. Alcohol 35 :899.

    Google Scholar 

  • Ludwig, A. M., Wikler, A., and Stark, L. H., 1974, The first drink: Psychobiological aspects of craving, Arch. Gen. Psychiatry 30 :539.

    Google Scholar 

  • Ludwig, A. M., Cain, R. B., Wikler, A., Taylor, R. M., and Bendfeldt, F., 1977, Physiologic and situational determinants of drinking behavior, in: Alcohol Intoxication and Withdrawal/ lib: Studies in Alcohol Dependence ( M. M. Gross, ed.), pp. 589 - 600, Plenum Press, New York.

    Google Scholar 

  • Lynch, J. J., Stein, E. A., and Fertziger, A. P., 1976, An analysis of 70 years of morphine classical conditioning: Implications for clinical treatment of narcotic addiction, J. Nerv. Ment. Dis. 163: 47.

    Google Scholar 

  • McGlothlin, W. H., Anglin, M. D., and Wilson, B. D., 1975176, Outcome of the Califomia civil addict commitments: 1961-1972, Drug Alcohol Dep. 1 :165.

    Google Scholar 

  • Mackintosh, N. I., 1974, The Psychology of Animal Learning, Academic Press, London.

    Google Scholar 

  • Mann, R. E., and Vogel-Sprott, M., 1981, Control of alcohol tolerance by reinforcement in nonalcoholics, Psychopharmacology 75 :315.

    Google Scholar 

  • Mansfield, I. G., and Cunningham, C. L., 1980, Conditioning and extinction of tolerance to the hypothennic effect of ethanol in rats, J. Compo Physiol. Psychol. 94 :962.

    Google Scholar 

  • Mansfield, I. G., and Woods, S. C., 1981, Cross-tolerance between the hypotbennic effects of ethanol and morphine: An associative account, Alc. Clin. Exp. Res. 5 :160.

    Google Scholar 

  • Mason, P., 1967, Mortality among narcotic addicts, Mount Sinai J. Med. N.Y. 34 :4.

    Google Scholar 

  • Mathew, R. I., Claghom, I. L., and Largen, 1.,1979, Craving for alcohol in sober alcoholics, Am. J. Psychiatry 136 :603.

    Google Scholar 

  • Maurer, D. W., and Vogel, V. H., 1973, Narcotics and Narcotic Addiction, 4th ed. Charles C. Thomas, Springfield, Illinois.

    Google Scholar 

  • Melchior, C. L., and Tabakoff, B., 1981, Modification of environmentally-cued tolerance to ethanol in mice, J. Pharmacol. Exp. Ther. 219 :175.

    Google Scholar 

  • Mello, N. K., 1979, Animal models of alcoholism: Progress and prospects, in: Modification of Pathological Behavior ( R. S. Davidson, ed.), pp. 273 - 333, Gardner Press, New York.

    Google Scholar 

  • Merry, J., 1966, The “loss of control” myth, Lancet 1 :1257.

    Google Scholar 

  • Meyer, R. E., and Mirin, S. M., 1979, The Heroin Stimulus: Implicationsfora Theory of Addiction, Plenum Press, New York.

    Google Scholar 

  • Milby, J. B., 1981, Addictive Behavior and Its Treatment, Springer, New York.

    Google Scholar 

  • Mityushov, M. I., 1954, Uslovnorleflektornaya inkretsiya insulina (The conditional-reflex incretion of insulin), Zhurnal Vysshei Nervnoi Deiatel (J. Higher Nervous Activity), 4 :206.

    Google Scholar 

  • Mucha, R. F., Volkovskis, C., and Kalant, H., 1981, Conditioned increases in locomotor activity produced with morphine as an unconditioned stimulus, and the relation of conditioning to acute morphine effect and tolerance, J. Compo Physiol. Psychol. 95: 35l.

    Google Scholar 

  • Mulinos, M. G., and Lieb, C. C., 1929, Pharmacology of learning, Am. J. Physiol. 90 :456.

    Google Scholar 

  • Nace, E. P., and Meyers, A. L., 1974, The prognosis for addicted Vietnam returnees: A comparison with civilian addicts, Compr. Psychiat. 15 :49.

    Google Scholar 

  • Nakajima, S., 1976, Cycloheximide: Mechanisms of its amnesic effect, Current Dev. Psychopharmacol. 3 :26.

    Google Scholar 

  • National Academy of Sciences National Research Council, 1977, Common Process in Habitual Substance Use: A Research Agenda, National Academy of Sciences, Washington, D.C.

    Google Scholar 

  • Obal, F., 1966, The fundaments of the central nervous control of vegetative homeostasis, Acta Physiol. Acad. Sci. Hung. 30 :15.

    Google Scholar 

  • Obal, F., Vicsay, M., and Madarasz, I., 1965, Role of a central nervous mechanism in the acquired tolerance to the temperature decreasing effect of histamine, Acta Physiol. Acad. Sci. Hung. 28: 65.

    Google Scholar 

  • O’Brien, C. P., 1976, Experimental analysis of conditioning factors in human narcotic addiction, Pharmacol. Rev. 27 :533.

    Google Scholar 

  • O’Brien, C. P., and Ng, L. K. Y., 1979, Innovative treatments for drug addiction, in: Handbook on Drug Abuse ( R. I. Dupont, A. Goldstein and J. O’Donnell, eds.), pp. 193–201, U. S. Government Printing Office, Washington, D.C.

    Google Scholar 

  • O’Brien, C. P., Chaddock, B., Woody, G., and Greenstein, R., 1974, Systematic extinction of addiction-associated rituals using narcotic antagonists, Psychosom. Med. 36 :458.

    Google Scholar 

  • O’Brien, C. P., Testa, T., O’Brien, T. J., and Greenstein, R., 1976, Conditioning in human opiate addicts, Pavlovian J. Bioi. Sci. 4 :195.

    Google Scholar 

  • O’Brien, C. P., Nace, E. P., Mintz, J., Meyers, A. L., and Ream, N., 1980, Follow-up of Vietnam veterans, I. Relapse to drug use after Vietnam service, Drug Alcohol Dep. 5 :333.

    Google Scholar 

  • Pavlov, I. P., 1927, Conditioned Reflexes (G. V. Anrep, translator), Oxford University Press, London.

    Google Scholar 

  • Pihl, R. 0., and Altman, J., 1971, An experimental analysis of the placebo effect, J. Clin. Pharmacol. 11: 9l.

    Google Scholar 

  • Poulos, C. X., Hinson, R. E., and Siegel, S., 1981, The role of Pavlovian processes in drug use: Implications for treatment, Addict. Beh. 6 :205.

    Google Scholar 

  • Poulos, C. X., Wilkinson, D. A., and Cappell, H., 1981, Homeostatic regulation and pavlovian conditioning in tolerance to amphetamine-induced anorexia, J. Compo Physiol. Psychol. 95 :735.

    Google Scholar 

  • Raw, M., 1978, The treatment of cigarette dependence, in: Research Advances in Alcohol and Drug Problems Vol. 4 ( Y. Israel, F. B. Glaser, H. Kalant, R. E. Popham, W. Schmidt, and R. G. Smart, eds.), pp. 441–485, Plenum Press, New York.

    Google Scholar 

  • Reed, T., 1980, Challenging some “common wisdom” on drug abuse, Int. J. Addict. 15 :359.

    Google Scholar 

  • Rescorla, R. A., 1969, Pavlovian conditioned inhibition, Psychol. Bull. 72 :77.

    Google Scholar 

  • Reynolds, A. K., and Randall, L. 0., 1957, Morphine and Allied Drugs, University of TorontoPress, Toronto.

    Google Scholar 

  • Robins, L. N., 1973, The Vietnam Drug User Returns Executive Office of the President, SpecialAction Office for Drug Abuse Prevention, Special Action Office Monograph, Series A., Number 2, U. S. Government Printing Office, Washington, D. C.

    Google Scholar 

  • Robins, L. N., Davis, D. H., and Goodwin, D. W., 1974, Drug use by U. S. Army enlisted men in Vietnam: A follow-up on their return home, Am. J. Epidem. 99 :235.

    Google Scholar 

  • Robins, L. N., Helzer, J. E., and Davis, D. H., 1975, Narcotic use in southeast Asia and afterwards, Arch. Gen. Psych. 32 :955.

    Google Scholar 

  • Roffman, M., and LaI, H., 1974, Stimulus control of hexobarbital narcosis and metabolism in mice, J. Pharmacol. Exp. Ther. 191 :358.

    Google Scholar 

  • Rudy, T. A., and Yaksh, T. L., 1977, Hyperthermic effects of morphine: Set point manipulation by a direct spinal action, Br. J. Pharmacol. 61 :91.

    Google Scholar 

  • Rush, M. L., Pearson, L., and Lang, W. J., 1970, Conditional autonomic responses induced in dogs by atropine and morphine, Eur. J. Pharmacol. 11 :22.

    Google Scholar 

  • Russek, M., and Pifia, S., 1962, Conditioning of adrenalin anorexia, Nature 193 :1296.

    Google Scholar 

  • Saunders, W. M., and Kershaw, P. W., 1979, Spontaneous remission from aIcoholism-A community study, Br. J. Addict. 74 :251.

    Google Scholar 

  • Schachter, S., 1977, Studies of the interaction of psychological and pharmacological determinants of smoking: 1. Nicotine regulation in heavy and light smokers, J. Exp. Psychol.: Gen. 106 :5.

    Google Scholar 

  • Schachter, S., Silverstein, B., Kozlowski, L. T., Herman, C. P., and Liebling, B., 1977, Studies of the interaction of psychological and pharmacological determinants of smoking: 4. Effects of stress on cigarette smoking and urinary pH, J. Exp. Psychol.: Gen. 106 :24.

    Google Scholar 

  • Schuster, C. R., Dockins, W. S., and Woods, J. H., 1966, Behavioral variables affecting the development of amphetamine tolerance, Psycho pharmacologia (Berl.) 9 :170.

    Google Scholar 

  • Senate Testimony, 1972, Hearing Before the Subcommittee to Investigate Juvenile Delinquency of the Committee on the Judiciary United States Senate, Ninety Second Congress, U. S. Government Printing Office, Washington, D. C.

    Google Scholar 

  • Sherman, J. E., 1979, The effects of conditioning and novelty on the analgesic and pyretic responses to morphine, Learn. Motiv. 10 :383.

    Google Scholar 

  • Sideroff, S. I., and Jarvik, M. E., 1980, Conditioned responses to a videotape showing heroin related stimuli, Int. J. Addict. 15 :529.

    Google Scholar 

  • Siegel, S., 1972, Conditioning of insulin-induced glycemia, J. Compo Physiol. Psychol. 78 :233.

    Google Scholar 

  • Siegel, S., 1975a, Conditioning insulin effects, J. Compo Physiol. Psychol. 89 :189.

    Google Scholar 

  • Siegel, S., 1975b, Evidence from rats that morphine tolerance is a learned response, J. Compo Physiol. Psychol. 89 :498.

    Google Scholar 

  • Siegel, S., 1976, Morphine analgesic tolerance: Its situation specificity supports a Pavlovian conditioning model, Science 193 :323.

    Google Scholar 

  • Siegel, S., 1977a, Learning and psychopharmacology, in: Psychopharmacology in the Practice of Medicine (M. E. Jarvik, ed.), pp. 59-70, Appleton-Century-Crofts, New York.

    Google Scholar 

  • Siegel, S., 1977b, Morphine tolerance acquisition as an associative process, J. Exp. Psych.: Anim. Behav. Proc. 3: 1.

    Google Scholar 

  • Siegel, S., 1978a, A Pavlovian conditioning analysis of morphine tolerance, in: Behavioral Tolerance: Research and Treatment Implications (N. A. Krasnegor, ed.), National Institute onDrug Abuse Research Monograph, No. 18; U. S. Department of Health, Education, and WelfarePublication No. (ADM)78-551, U. S. Government Printing Office, Washington, D. C.

    Google Scholar 

  • Siegel, S., 1978b, Morphine tolerance: Is there evidence for a conditioning model? Science 200 :344.

    Google Scholar 

  • Siegel, S., 1978c, Tolerance to the hyperthermic effect of morphine in the rat is a learned response, J. Compo Physiol. Psychol. 92 :1137.

    Google Scholar 

  • Siegel, S., 1979a, Pharmacological learning and drug dependence, in: Research in Psychology and Medicine (D. J. Oborne, M. M. Gruneberg, and J. R. Eiser, eds.), pp. 127–134, AcademicPress, New York.

    Google Scholar 

  • Siegel, S., 1979b, The role of conditioning in drug tolerance and addiction, in: Psychopathology in Animals: Research and Treatment Implications (J. D. Keehn, ed.), pp. 143-168, AcademicPress, New York.

    Google Scholar 

  • Siegel, S., 1982, Opioid expectation modifies opioid effects, Fed. Proc. 41 :2339.

    Google Scholar 

  • Siegel, S., 1982, Opioid expectation modifies opioid effects, Fed. Proc. 41 :2339.

    Google Scholar 

  • Siegel, S., 1982, Opioid expectation modifies opioid effects, Fed. Proc. 41 :2339.

    Google Scholar 

  • Siegel, S., Hinson, R. E., and Krank, M. D., 1978, The role of predrug signals in morphine analgesic tolerance: Support for a Pavlovian conditioning model of tolerance, J. Exp. Psychol.: Anim. Behav. Proc. 4 :188.

    Google Scholar 

  • Siegel, S., Hinson, R. E., and Krank, M. D., 1979, Modulation of tolerance to the lethal effect of morphine by extinction, Behav. Neur. Bioi. 25 :257.

    Google Scholar 

  • Siegel, S., Sherman, J. E., and Mitchell, D., 1980, Extinction of morphine analgesic tolerance, Learn. Motiv. 11 :289.

    Google Scholar 

  • Siegel, S., Hinson, R. E., and Krank, M. D., 1981, Morphine-induced attenuation of morphine tolerance, Science 212 :1533.

    Google Scholar 

  • Siegel, S., Hinson, R. E., Krank, M. D., and McCully, J., 1982, Heroin “overdose” death: The contribution of drug-associated environmental cues, Science 216 :436.

    Google Scholar 

  • Sjoberg, L., and Olsson, G., 1981, Volitional problems in carrying through a difficult decision: The case of drug addiction, Drug Alcohol Dep. 7 :177.

    Google Scholar 

  • Solomon, R. L., 1977, An opponent process theory of acquired motivation: The affective dynamics of addiction, in: Psychopathology: Experimental Models ( J. D. Maser, and M. E. P., Seligman, eds.), pp. 66–103, Freeman, San Francisco.

    Google Scholar 

  • Stolerman, I. P., Bunker, P., Johnson, C. A., Jarvik, M. E., Krivoy, W, and Zimmermann, E., 1976, Attenuation of morphine tolerance development by electroconvulsive shock in mice, Neuropharmacology 15 :309.

    Google Scholar 

  • Subkov, A. A., and Zilov, G. N., 1937, The role of conditioned reflex adaptation in the origin of hyperergic reactions, Bull. Bioi. Med. Exp. 4 :294.

    Google Scholar 

  • Tabakoff, B., Melchior, C. L., and Hoffman, P. L., 1982, Commentary on ethanol tolerance, Alc: Clin. Exp. Res. 6 :252.

    Google Scholar 

  • Teasdale, J. D., 1973, Conditioned abstinence in narcotic addicts, Int. J. Addict. 8 :273.

    Google Scholar 

  • Thompson, T., and Ostlund, Jr., W., 1965, Susceptibility to readdiction as a function of the addiction and withdrawal environments, J. Compo Physiol. Psychol. 60 :388.

    Google Scholar 

  • Thornhill, J. A., Hirst, M., and Gowdey, C. W., 1978, Changes in the hyperthermic responses of rats to daily injections of morphine and the antagonism of the acute response by naloxone, Can. J. Physiol. Pharmacol. 56 :483.

    Google Scholar 

  • Tiffany, S. T., and Baker, T. B., 1981, Morphine tolerance in the rat: Congruence with a Pavlovian paradigm, J. Compo Physiol. Psychol. 95 :747.

    Google Scholar 

  • Walter, R., Ritzmann, R. F., Bhargava, H. N., Rainbow, T. C., Flexner, L. B., and Krivoy, W., 1978, Inhibition by Z-Pro-D-Leu of development of tolerance to and physical dependence on morphine in mice, Proc. Natl. Acad. Sci. 75 :4573.

    Google Scholar 

  • Warren, J. M., and Akert, K., eds., 1964, The Frontal Granular Cortex and Behavior, McGrawHill, New York.

    Google Scholar 

  • Way, E. L., Loh, H. H., and Shen, F., 1969, Simultaneous quantitative assessment of morphine tolerance and physical dependence, J. Pharmacol. Exp. Ther. 67 :1.

    Google Scholar 

  • Wenger, J. R., Tiffany, T. M., Bombardier, C., Nicholls, K., and Woods, S. C., 1981, Ethanol tolerance in the rat is learned, Science 213 :575.

    Google Scholar 

  • Werner, A., 1969, Near-fatal hyperacute reaction to intravenously administered heroin, J. Am. Med. Assoc. 1AY 1 :2277.

    Google Scholar 

  • Wilder, A., 1973, Conditioning of successive adaptive responses to the initial effects of drugs, Condo Reflex 8 :193.

    Google Scholar 

  • Wilder, A., 1977, The search for the psyche in drug dependence: A 35-year retrospective survey, J. Nerv. Ment. Dis. 163 :29.

    Google Scholar 

  • Wilder, A., 1980, Opioid Dependence: Mechanisms and Treatment, Plenum Press, New York.

    Google Scholar 

  • Zinberg, N. E., 1972, Rehabilitation of heroin users in Vietnam, Contemp. Drug Probl. 1 :263.

    Google Scholar 

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  1. Department of Psychology, McMaster University, Hamilton, Ontario, L8S4K1, Canada

    Shepard Siegel

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© 1983 Plenum Press, New York

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Siegel, S. (1983). Classical Conditioning, Drug Tolerance, and Drug Dependence. In: Research Advances in Alcohol and Drug Problems. Research Advances in Alcohol and Drug Problems, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3626-6_6

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  • DOI: https://doi.org/10.1007/978-1-4613-3626-6_6

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