Abstract
Most theories of drug tolerance and dependence stress the physiological consequences of repeated pharmacological stimulation. There is considerable evidence, however, that the organism’s experience with the drug administration environment, as well as the drug, often importantly contributes to tolerance and dependence. The role of such environmental cues has been elaborated in a model which emphasizes Pavlovian conditioning principles. This account is based on the work of a number of investigators, but primarily Wikler (e.g., 1973, 1977, 1980), who have stressed the contribution of pharmacological learning to drug effects. This chapter describes the conditioning theory of tolerance, summarizes the data which supports the theory, discusses the relevance of the theory to drug dependence, and presents the implications ofthe theory for the treatment of drug abuse. Since some of the material has been summarized previously (Hinson and Siegel, 1980; Siegel, 1978a, 1979 b), this chapter emphasizes developments subsequent to earlier reviews.
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References
Abelson, P. H., 1970, Death from heroin, Science 168 :1289.
Adam, G., 1967, Interoception and Behavior, Publishing House of the Hungarian Academy of Sciences, Budapest.
Adams, W. J., Yeh, S. Y., Woods, L. A., and Mitchell, C. L., 1969, Drug-test interaction as a factor in the development of tolerance to the analgesic effect of morphine, J. Pharmacol. Exp. Ther. 168 :251.
Advokat, C., 1980, Evidence for conditioned tolerance of the tail flick reflex, Behav. Neur. Bioi. 29: 385.
Blakey, R., and Baker, R., 1980, An exposure approach to alcohol abuse, Behav. Res. Ther. 18 :319.
Bourne, L. J. Jr., and Ekstrand, B. R., 1979, Psychology: Its Principles and Meanings, Holt, Rinehart and Winston, New York.
Bower, G. H., 1981, Mood and memory, Am. Psychol. 36 :129.
Brecher, E. M., 1972, Licit and Illicit Drugs, Little, Brown, Boston.
Bykov, K. M., 1959, The Cerebral Cortex and the Internal Organs, Foreign Languages, Moscow.
Cappell, H., and leBlanc, A. E., 1981, Tolerance and physical dependence: Do they playa role in alcohol and drug self-administration? in: Research Advances in Alcohol and Drug Problems Vol. 6 (Y. Israel, F. Glaser, H. Kalant, R. E. Popham, W. Schmidt, and R. G. Smart, eds.), Plenum Press, New York.
Cappell, H., Roach, C., and Poulos, C. X., 1981, Pavlovian control of cross-tolerance between pentobarbital and ethanol, Psychopharmacology 74 :54.
Cherubin, C., McCusker, J., Baden, M., Kavaler, F., and Amsel, Z., 1972, The epidemiology of death in narcotic addicts, Am. J. Epidemiol. 96 :11.
Clark, W. G., and Clark, Y. L., 1980, Changes in body temperature after administration of acetylcholine, histamine, morphine, prostaglandins and related agents. Neurosci. Biobehav. Rev. 4: 175.
Cochin, J., 1972, Some aspects of tolerance to the narcotic analgesics, in: Drug Addition 1. Experimental Pharmacology ( J. M. Singh, L. Miller, and H. S. Lal, eds.), pp. 365–375, Futura, New York.
Cochin, J., and Kornetsky, C., 1964, Development and loss of tolerance to morphine in the rat after single and multiple injections, J. Pharmacol. Exp. Ther. 145 :1.
Cohen, M., Keats, A. S. Krivoy, W., and Ungar, G., 1965, Effect of actinomycin D on morphine tolerance, Proc. Soc. Exp. Bioi. Med. 119 :381.
Collins, W., 1966, The Moonstone, Penguin Books, Harmondsworth, England (Originally published in 1868 ).
Crowell, C. R., Hinson, R. E., and Siegel, S., 1981, The role of conditional drug responses in tolerance to the hypothermic effect of ethanol, Psychopharmacology 73 :51.
Deutsch, R., 1974, Conditioned hypoglycemia: A mechanism for saccharin-induced sensitivity to insulin in the rat, J. Compo Physiol. Psychol. 86 :350.
Dews, P. B., 1962, Psychopharmacology, in: Experimental Foundations of Clinical Psychology (A. I. Bachrach, ed.), pp. 423 - 441, Basic Books, New York.
Domjan, M., and Burkhard, B., 1982, The Principles 0/ Learning and Behavior, Brooks/Cole, Monterey, California.
Domjan, M., and Gillan, D. J., 1977, Aftereffects of lithium-conditioned stimuli on consummatory behavior, J. Exp. Psychol: Anim. Behav. Proc., 3 :322.
Duberstein, J. L., and Kaufman, D. M., 1971, A clinical study of an epidemic of heroin intoxication and heroin-induced pulmonary edema, Am. J. Med. 51 :704.
Eikelboom, R., and Stewart, J., 1979, Conditioned temperature effects using morphine as the unconditioned stimulus, Psychopharmacology 61 :31.
Eikelboom, R., and Stewart, J., 1981, Temporal and environmental cues in conditioned hypothennia and hypertbennia associated with morphine, Psychopharmacology 72 :147.
Fennessy, M. R., and Lee, J. R., 1975, The assessment of and the problems involved in the experimental evaluation of narcotic analgesics, in: Methods in Narcotics Research (S. Ehrenpreis and A. Neidle, eds.), pp. 73– 99, Marcel Dekker, New York.
Ferguson, R. K., and Mitchell, C. L., 1969, Pain as a factor in the development of tolerance to morphine analgesia in man, Clin. Pharmacol. Ther. 10 :372.
Foxx, R. M., and Brown, R. A., 1979, Nicotine fading and self-monitoring for cigarette abstinence or controlled smoking, J. Appl. Behav. Anal. 12 :111.
Fulmer, R. H., and Lapidus, L. B., 1980, A study of professed reasons for beginning and continuing heroin use, Int. J. Addict. 15 :631.
Ginsburg, M., and Cox, B. M., 1972, Proteins and nucleic acids, in: Chemical and Biological Aspects of Drug Dependence (S. J. Mule and H. Brill, eds.), pp. 465–475, CRC Press, Cleveland.
Goldberg, S. R., and Schuster, C. R., 1967, Conditioned suppression by a stimulus associated with nalorphine in morphine-dependent monkeys, J. Exp. Anal. Behav. 10 :235.
Goldberg, S. R., and Schuster, C. R., 1970, Conditioned nalorphine-induced abstinence changes: Persistence in post morphine-dependent monkeys, J. Exp. Anal. Behav. 14 :33.
Goldstein, D. B., and Pal, N., 1971, Alcohol dependence produced in mice by inhalation of ethanol: Grading the withdrawal reaction, Science 172 :288.
Government of Canada, 1973, Final Report of the Commission 0/ Inquiry Into the Nonmedical Use of Drugs. Infonnation Canada. Ottawa. Ontario.
Grabowski, J., and O’Brien, C. B., 1982, Conditioning factors in opiate use, in Advances in Substance Abuse Vol. 2 (N. Mello, ed.), JAI Press, Greenwich, Connecticut.
Greeley, J. D., 1981, “Conditioning and Tolerance to Chlordiazepoxide.“ unpublished M. A. thesis, University of Toronto.
Greene, M. H., Luke, J. L., and Dupont, R. L.. 1974. Opiate “overdose” deaths in the District of Columbia I. Heroin-related fatalities, Med. Ann. District o/Columbia 43 :175.
Griffiths, R. R., Bigelow, G. E., and Henningfield, I. E., 1980, Similarities in animal and human drug-taking behavior, in: Advances in Substance Abuse: Behavioral and Biological Research (N. K. Mello, ed.), pp. 1-90, JAI Press, Greenwich, Connecticut.
Guha, D., Dutta, S. N., and Pradham, S. N., 1974, Conditioning of gastric secretion by epinephrine in rats, Proc. Soc. Exp. Bioi. Med. 147 :817.
Harvey. J. G., 1981, Drug-related mortality in an inner city area, Drug Ale. Dep. 7 :239.
Hecht, T., Baumann, R., and Hecht, K., 1967, The somatic and vegetative regulatory behavior of the healthy organism during conditioning of the insulin effect, Condo Reflex 2 :96.
Helpern, M., 1972, Fatalities from narcotic addiction in New York City: Incidence, circumstances, and pathologic findings, Hum. Pathol. 3 :13.
Helzer, J. E., Robins, L. N., and Davis, D. H., 1975176, Antecedents of narcotic use and addiction: A study of 898 Vietnam veterans, Drug Alcohol Dep. 1:183.
Himmelsbach, C. K., 1943, Symposium: Can the euphoric, analgetic and physical dependence effects of drugs be separated? IV. With reference to physical dependence, Fed. Proc. 2 :201.
Hinson, R. E., and Siegel, S., 1980, The contribution of Pavlovian conditioning to ethanol tolerance and dependence, in: Alcohol Tolerance, Dependence, and Addiction ( H. Rigter and J. C. Crabbe, Jr., eds.), pp. 181–199, Elsevier/North-Holland Biomedical Press, Amsterdam.
Hinson, R. E., and Siegel, S., 1982, Nonpharmacological bases of drug tolerance and dependence,
J. Psychosom. Res., 26:495.
Hinson, R. E., Poulos, C. X., and Cappell, H., 1982, The effects of pentobarbital and cocaine in rats expecting pentobarbital, Pharmacol. Biochem. Behav. 16 :661.
Hodgson, R., 1980, Review of “Behavioural Tolerance: Research and Treatment Implications,” Br. J. Addict. 75 :101.
Hodgson, R. J., and Rankin, H. J., 1976, Modification of excessive drinking by cue exposure, Behav. Res. Ther. 14 :305.
Huber, D. H., 1974, Heroin deaths-Mystery or overdose? J. Am. Med. Assoc. 229 :689.
Hug, C. C., 1972, Characteristics and theories related to acute and chronic tolerance development, in: Chemical and Biological Aspects of Drug Dependence ( S. J. Mule and H. Brill, eds.), pp. 307–358, CRC Press, Cleveland.
Hunt, W. A., Barnett, L. W., and Branch, L. G., 1971, Relapse rates in addiction programs, J. c/in. Psychol. 27 :455.
Jaffe, J. H., 1980, Drug addiction and drug abuse, in: The Pharmacological Basis of Therapeutics, 6th ed. ( A. S. Goodman, L. S. Goodman, and A. Gilman, eds.), pp. 535–584, Macmillan, New York.
Jaffe, J. H., and Martin, W. R., 1980, Narcotic analgesics and antagonists, in: The Pharmacological Basis of Therapeutics, 6th ed. ( A. S. Goodman, L. S. Goodman, and A. Gilman, eds.), pp. 494–534, Macmillan, New York.
Jones, B. M., 1974, Circadian variation in the effects of alcohol on cognitive performance, Q. J. Stud. Alcohol 35 :1212.
Kalant, H., 1977, Comparative aspects of tolerance to, and dependence on, alcohol, barbiturates, and opiates, in: Alcohol Intoxication and Withdrawal-lllb: Studies in Alcohol Dependence ( M. Gross, ed.), pp. 57 - 64, Plenum Press, New York.
Kalant, H., leBlanc, A. E., and Gibbins, R. J., 1971, Tolerance to, and dependence on, some non-opiate psychotropic drugs, Pharmacol. Rev. 23 :135.
Kesner, R. P., and Baker, T. B., 1981, A two-process model of opiate tolerance, in: Endogenous Peptides, Learning and Memory Processes (J. Martinez, J. L., Jensen, R. R., Messing, H. E.
Rigter, and 1. L. McGaugh, eds.), pp. 479–518, Academic Press, New York.
Kesner, R. P., Priano, D. J., and DeWitt, J. R., 1976, Time-dependent disruption of morphine tolerance by electroconvulsive shock and frontal cortical stimulation, Science 194 :1079.
Khanna, J. M., Le, A. D., Kalant, H., and leBlanc, A. E., 1979, Cross-tolerance between ethanol and morphine with respect to their hypothermic effects, Eur. J. Pharmacol. 59 :145.
Kimble, G., 1961, Hilgard and Marquis' Conditioning and Learning, Appleton-Century-Crofts, New York.
Kornetsky, C., and Bain G., 1968, Morphine: Single-dose tolerance, Science 162 :1011.
Korol, B., and Mclaughlin, L. J., 1976, A homeostatic adaptive response to alpha-methyl-dopa in conscious dogs, Pavlovian J. Bioi. Sci. 11 :67.
Korol, B., Sletten, I. W., and Brown, M. L., 1966, Conditioned physiological adaptation to anticholinergic drugs, Am. J. Physiol. 211 :911.
Kraft, T., 1970, Treatment of Drinamyl addiction: Two case studies, J. Nerv. Ment. Dis. 150 :138.
Krank, M. D., Hinson, R. E., and Siegel, S., 1981, Conditional hyperalgesia is elicited by environmental signals of morphine, Behav. Neur. Bioi. 32 :148.
Krivoy, W. A., Zimmermann, E., and Lande, S., 1974, Facilitation of development of resistance to morphine analgesia by Desglycinamide9-Lysine Vasopressin, Proc. Natl. Acad. Sci. 71: 1852.
Krylov, V., 1933, Additional data on the study of conditioned reflexes on chemical stimuli, Bioi. Abstr. 7 :871.
LaHoste, G. J., Olson, R. D., Olson, G. A., and Kastin, A. J., 1980, Effects of Pavlovianconditioning and MIF-I on the development of morphine tolerance in rats, PhaT TUlcol. Biochem. Behav. 13 :799.
Le, A. D., Poulos, C. X., and Cappell, H., 1979, Conditioned tolerance to the hypothennic effect of ethyl alcohol, Science 206 :1109.
leBlanc, A. E., Matsunaga, M., and Kalant, H., 1976, Effects of frontal polar cortical ablation and cycloheximide on ethanol tolerance in rats, PhaT TUlcol. Biochem. Behav. 4 :175.
leBlanc, A. E., Poulos, C. X., and Cappell, H. D., 1978, Tolerance as a behavioral phenomenon: Evidence from two experimental paradigms, in: Behavioral Tolerance: Research and Treatment Implications, National Institute on Drug Abuse Research Monograph No. 18; U. S. Department
of Health, Education, and Welfare Publication No. [ADM] 78-551, (N. A. Krasnegor, ed.), pp. 72-79, U. S. Government Printing Office, Washington, D. C.
Lesser, E., 1967, Behavior therapy with a narcotics user: A case report, Behav. Res. Ther. 5 :251.
Lightfoot, L. 0.,1980, Behavioral Tolerance to Low Doses of Alcohol in Social Drinkers, unpublished Ph.D. thesis, Waterloo University.
Louria, D. B., Hensle, T., and Rose, J., 1967, The major medical complications of heroin addiction, Ann. Intern. Med. 67 :1.
Lubow, R. E., 1973, Latent inhibition, Psychol. Bull. 79 :398.
Ludwig, A. M., and Stark, L. H., 1974, Alcohol craving: Subjective and situational aspects, Q. J. Stud. Alcohol 35 :899.
Ludwig, A. M., Wikler, A., and Stark, L. H., 1974, The first drink: Psychobiological aspects of craving, Arch. Gen. Psychiatry 30 :539.
Ludwig, A. M., Cain, R. B., Wikler, A., Taylor, R. M., and Bendfeldt, F., 1977, Physiologic and situational determinants of drinking behavior, in: Alcohol Intoxication and Withdrawal/ lib: Studies in Alcohol Dependence ( M. M. Gross, ed.), pp. 589 - 600, Plenum Press, New York.
Lynch, J. J., Stein, E. A., and Fertziger, A. P., 1976, An analysis of 70 years of morphine classical conditioning: Implications for clinical treatment of narcotic addiction, J. Nerv. Ment. Dis. 163: 47.
McGlothlin, W. H., Anglin, M. D., and Wilson, B. D., 1975176, Outcome of the Califomia civil addict commitments: 1961-1972, Drug Alcohol Dep. 1 :165.
Mackintosh, N. I., 1974, The Psychology of Animal Learning, Academic Press, London.
Mann, R. E., and Vogel-Sprott, M., 1981, Control of alcohol tolerance by reinforcement in nonalcoholics, Psychopharmacology 75 :315.
Mansfield, I. G., and Cunningham, C. L., 1980, Conditioning and extinction of tolerance to the hypothennic effect of ethanol in rats, J. Compo Physiol. Psychol. 94 :962.
Mansfield, I. G., and Woods, S. C., 1981, Cross-tolerance between the hypotbennic effects of ethanol and morphine: An associative account, Alc. Clin. Exp. Res. 5 :160.
Mason, P., 1967, Mortality among narcotic addicts, Mount Sinai J. Med. N.Y. 34 :4.
Mathew, R. I., Claghom, I. L., and Largen, 1.,1979, Craving for alcohol in sober alcoholics, Am. J. Psychiatry 136 :603.
Maurer, D. W., and Vogel, V. H., 1973, Narcotics and Narcotic Addiction, 4th ed. Charles C. Thomas, Springfield, Illinois.
Melchior, C. L., and Tabakoff, B., 1981, Modification of environmentally-cued tolerance to ethanol in mice, J. Pharmacol. Exp. Ther. 219 :175.
Mello, N. K., 1979, Animal models of alcoholism: Progress and prospects, in: Modification of Pathological Behavior ( R. S. Davidson, ed.), pp. 273 - 333, Gardner Press, New York.
Merry, J., 1966, The “loss of control” myth, Lancet 1 :1257.
Meyer, R. E., and Mirin, S. M., 1979, The Heroin Stimulus: Implicationsfora Theory of Addiction, Plenum Press, New York.
Milby, J. B., 1981, Addictive Behavior and Its Treatment, Springer, New York.
Mityushov, M. I., 1954, Uslovnorleflektornaya inkretsiya insulina (The conditional-reflex incretion of insulin), Zhurnal Vysshei Nervnoi Deiatel (J. Higher Nervous Activity), 4 :206.
Mucha, R. F., Volkovskis, C., and Kalant, H., 1981, Conditioned increases in locomotor activity produced with morphine as an unconditioned stimulus, and the relation of conditioning to acute morphine effect and tolerance, J. Compo Physiol. Psychol. 95: 35l.
Mulinos, M. G., and Lieb, C. C., 1929, Pharmacology of learning, Am. J. Physiol. 90 :456.
Nace, E. P., and Meyers, A. L., 1974, The prognosis for addicted Vietnam returnees: A comparison with civilian addicts, Compr. Psychiat. 15 :49.
Nakajima, S., 1976, Cycloheximide: Mechanisms of its amnesic effect, Current Dev. Psychopharmacol. 3 :26.
National Academy of Sciences National Research Council, 1977, Common Process in Habitual Substance Use: A Research Agenda, National Academy of Sciences, Washington, D.C.
Obal, F., 1966, The fundaments of the central nervous control of vegetative homeostasis, Acta Physiol. Acad. Sci. Hung. 30 :15.
Obal, F., Vicsay, M., and Madarasz, I., 1965, Role of a central nervous mechanism in the acquired tolerance to the temperature decreasing effect of histamine, Acta Physiol. Acad. Sci. Hung. 28: 65.
O’Brien, C. P., 1976, Experimental analysis of conditioning factors in human narcotic addiction, Pharmacol. Rev. 27 :533.
O’Brien, C. P., and Ng, L. K. Y., 1979, Innovative treatments for drug addiction, in: Handbook on Drug Abuse ( R. I. Dupont, A. Goldstein and J. O’Donnell, eds.), pp. 193–201, U. S. Government Printing Office, Washington, D.C.
O’Brien, C. P., Chaddock, B., Woody, G., and Greenstein, R., 1974, Systematic extinction of addiction-associated rituals using narcotic antagonists, Psychosom. Med. 36 :458.
O’Brien, C. P., Testa, T., O’Brien, T. J., and Greenstein, R., 1976, Conditioning in human opiate addicts, Pavlovian J. Bioi. Sci. 4 :195.
O’Brien, C. P., Nace, E. P., Mintz, J., Meyers, A. L., and Ream, N., 1980, Follow-up of Vietnam veterans, I. Relapse to drug use after Vietnam service, Drug Alcohol Dep. 5 :333.
Pavlov, I. P., 1927, Conditioned Reflexes (G. V. Anrep, translator), Oxford University Press, London.
Pihl, R. 0., and Altman, J., 1971, An experimental analysis of the placebo effect, J. Clin. Pharmacol. 11: 9l.
Poulos, C. X., Hinson, R. E., and Siegel, S., 1981, The role of Pavlovian processes in drug use: Implications for treatment, Addict. Beh. 6 :205.
Poulos, C. X., Wilkinson, D. A., and Cappell, H., 1981, Homeostatic regulation and pavlovian conditioning in tolerance to amphetamine-induced anorexia, J. Compo Physiol. Psychol. 95 :735.
Raw, M., 1978, The treatment of cigarette dependence, in: Research Advances in Alcohol and Drug Problems Vol. 4 ( Y. Israel, F. B. Glaser, H. Kalant, R. E. Popham, W. Schmidt, and R. G. Smart, eds.), pp. 441–485, Plenum Press, New York.
Reed, T., 1980, Challenging some “common wisdom” on drug abuse, Int. J. Addict. 15 :359.
Rescorla, R. A., 1969, Pavlovian conditioned inhibition, Psychol. Bull. 72 :77.
Reynolds, A. K., and Randall, L. 0., 1957, Morphine and Allied Drugs, University of TorontoPress, Toronto.
Robins, L. N., 1973, The Vietnam Drug User Returns Executive Office of the President, SpecialAction Office for Drug Abuse Prevention, Special Action Office Monograph, Series A., Number 2, U. S. Government Printing Office, Washington, D. C.
Robins, L. N., Davis, D. H., and Goodwin, D. W., 1974, Drug use by U. S. Army enlisted men in Vietnam: A follow-up on their return home, Am. J. Epidem. 99 :235.
Robins, L. N., Helzer, J. E., and Davis, D. H., 1975, Narcotic use in southeast Asia and afterwards, Arch. Gen. Psych. 32 :955.
Roffman, M., and LaI, H., 1974, Stimulus control of hexobarbital narcosis and metabolism in mice, J. Pharmacol. Exp. Ther. 191 :358.
Rudy, T. A., and Yaksh, T. L., 1977, Hyperthermic effects of morphine: Set point manipulation by a direct spinal action, Br. J. Pharmacol. 61 :91.
Rush, M. L., Pearson, L., and Lang, W. J., 1970, Conditional autonomic responses induced in dogs by atropine and morphine, Eur. J. Pharmacol. 11 :22.
Russek, M., and Pifia, S., 1962, Conditioning of adrenalin anorexia, Nature 193 :1296.
Saunders, W. M., and Kershaw, P. W., 1979, Spontaneous remission from aIcoholism-A community study, Br. J. Addict. 74 :251.
Schachter, S., 1977, Studies of the interaction of psychological and pharmacological determinants of smoking: 1. Nicotine regulation in heavy and light smokers, J. Exp. Psychol.: Gen. 106 :5.
Schachter, S., Silverstein, B., Kozlowski, L. T., Herman, C. P., and Liebling, B., 1977, Studies of the interaction of psychological and pharmacological determinants of smoking: 4. Effects of stress on cigarette smoking and urinary pH, J. Exp. Psychol.: Gen. 106 :24.
Schuster, C. R., Dockins, W. S., and Woods, J. H., 1966, Behavioral variables affecting the development of amphetamine tolerance, Psycho pharmacologia (Berl.) 9 :170.
Senate Testimony, 1972, Hearing Before the Subcommittee to Investigate Juvenile Delinquency of the Committee on the Judiciary United States Senate, Ninety Second Congress, U. S. Government Printing Office, Washington, D. C.
Sherman, J. E., 1979, The effects of conditioning and novelty on the analgesic and pyretic responses to morphine, Learn. Motiv. 10 :383.
Sideroff, S. I., and Jarvik, M. E., 1980, Conditioned responses to a videotape showing heroin related stimuli, Int. J. Addict. 15 :529.
Siegel, S., 1972, Conditioning of insulin-induced glycemia, J. Compo Physiol. Psychol. 78 :233.
Siegel, S., 1975a, Conditioning insulin effects, J. Compo Physiol. Psychol. 89 :189.
Siegel, S., 1975b, Evidence from rats that morphine tolerance is a learned response, J. Compo Physiol. Psychol. 89 :498.
Siegel, S., 1976, Morphine analgesic tolerance: Its situation specificity supports a Pavlovian conditioning model, Science 193 :323.
Siegel, S., 1977a, Learning and psychopharmacology, in: Psychopharmacology in the Practice of Medicine (M. E. Jarvik, ed.), pp. 59-70, Appleton-Century-Crofts, New York.
Siegel, S., 1977b, Morphine tolerance acquisition as an associative process, J. Exp. Psych.: Anim. Behav. Proc. 3: 1.
Siegel, S., 1978a, A Pavlovian conditioning analysis of morphine tolerance, in: Behavioral Tolerance: Research and Treatment Implications (N. A. Krasnegor, ed.), National Institute onDrug Abuse Research Monograph, No. 18; U. S. Department of Health, Education, and WelfarePublication No. (ADM)78-551, U. S. Government Printing Office, Washington, D. C.
Siegel, S., 1978b, Morphine tolerance: Is there evidence for a conditioning model? Science 200 :344.
Siegel, S., 1978c, Tolerance to the hyperthermic effect of morphine in the rat is a learned response, J. Compo Physiol. Psychol. 92 :1137.
Siegel, S., 1979a, Pharmacological learning and drug dependence, in: Research in Psychology and Medicine (D. J. Oborne, M. M. Gruneberg, and J. R. Eiser, eds.), pp. 127–134, AcademicPress, New York.
Siegel, S., 1979b, The role of conditioning in drug tolerance and addiction, in: Psychopathology in Animals: Research and Treatment Implications (J. D. Keehn, ed.), pp. 143-168, AcademicPress, New York.
Siegel, S., 1982, Opioid expectation modifies opioid effects, Fed. Proc. 41 :2339.
Siegel, S., 1982, Opioid expectation modifies opioid effects, Fed. Proc. 41 :2339.
Siegel, S., 1982, Opioid expectation modifies opioid effects, Fed. Proc. 41 :2339.
Siegel, S., Hinson, R. E., and Krank, M. D., 1978, The role of predrug signals in morphine analgesic tolerance: Support for a Pavlovian conditioning model of tolerance, J. Exp. Psychol.: Anim. Behav. Proc. 4 :188.
Siegel, S., Hinson, R. E., and Krank, M. D., 1979, Modulation of tolerance to the lethal effect of morphine by extinction, Behav. Neur. Bioi. 25 :257.
Siegel, S., Sherman, J. E., and Mitchell, D., 1980, Extinction of morphine analgesic tolerance, Learn. Motiv. 11 :289.
Siegel, S., Hinson, R. E., and Krank, M. D., 1981, Morphine-induced attenuation of morphine tolerance, Science 212 :1533.
Siegel, S., Hinson, R. E., Krank, M. D., and McCully, J., 1982, Heroin “overdose” death: The contribution of drug-associated environmental cues, Science 216 :436.
Sjoberg, L., and Olsson, G., 1981, Volitional problems in carrying through a difficult decision: The case of drug addiction, Drug Alcohol Dep. 7 :177.
Solomon, R. L., 1977, An opponent process theory of acquired motivation: The affective dynamics of addiction, in: Psychopathology: Experimental Models ( J. D. Maser, and M. E. P., Seligman, eds.), pp. 66–103, Freeman, San Francisco.
Stolerman, I. P., Bunker, P., Johnson, C. A., Jarvik, M. E., Krivoy, W, and Zimmermann, E., 1976, Attenuation of morphine tolerance development by electroconvulsive shock in mice, Neuropharmacology 15 :309.
Subkov, A. A., and Zilov, G. N., 1937, The role of conditioned reflex adaptation in the origin of hyperergic reactions, Bull. Bioi. Med. Exp. 4 :294.
Tabakoff, B., Melchior, C. L., and Hoffman, P. L., 1982, Commentary on ethanol tolerance, Alc: Clin. Exp. Res. 6 :252.
Teasdale, J. D., 1973, Conditioned abstinence in narcotic addicts, Int. J. Addict. 8 :273.
Thompson, T., and Ostlund, Jr., W., 1965, Susceptibility to readdiction as a function of the addiction and withdrawal environments, J. Compo Physiol. Psychol. 60 :388.
Thornhill, J. A., Hirst, M., and Gowdey, C. W., 1978, Changes in the hyperthermic responses of rats to daily injections of morphine and the antagonism of the acute response by naloxone, Can. J. Physiol. Pharmacol. 56 :483.
Tiffany, S. T., and Baker, T. B., 1981, Morphine tolerance in the rat: Congruence with a Pavlovian paradigm, J. Compo Physiol. Psychol. 95 :747.
Walter, R., Ritzmann, R. F., Bhargava, H. N., Rainbow, T. C., Flexner, L. B., and Krivoy, W., 1978, Inhibition by Z-Pro-D-Leu of development of tolerance to and physical dependence on morphine in mice, Proc. Natl. Acad. Sci. 75 :4573.
Warren, J. M., and Akert, K., eds., 1964, The Frontal Granular Cortex and Behavior, McGrawHill, New York.
Way, E. L., Loh, H. H., and Shen, F., 1969, Simultaneous quantitative assessment of morphine tolerance and physical dependence, J. Pharmacol. Exp. Ther. 67 :1.
Wenger, J. R., Tiffany, T. M., Bombardier, C., Nicholls, K., and Woods, S. C., 1981, Ethanol tolerance in the rat is learned, Science 213 :575.
Werner, A., 1969, Near-fatal hyperacute reaction to intravenously administered heroin, J. Am. Med. Assoc. 1AY 1 :2277.
Wilder, A., 1973, Conditioning of successive adaptive responses to the initial effects of drugs, Condo Reflex 8 :193.
Wilder, A., 1977, The search for the psyche in drug dependence: A 35-year retrospective survey, J. Nerv. Ment. Dis. 163 :29.
Wilder, A., 1980, Opioid Dependence: Mechanisms and Treatment, Plenum Press, New York.
Zinberg, N. E., 1972, Rehabilitation of heroin users in Vietnam, Contemp. Drug Probl. 1 :263.
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Siegel, S. (1983). Classical Conditioning, Drug Tolerance, and Drug Dependence. In: Research Advances in Alcohol and Drug Problems. Research Advances in Alcohol and Drug Problems, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3626-6_6
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DOI: https://doi.org/10.1007/978-1-4613-3626-6_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-3628-0
Online ISBN: 978-1-4613-3626-6
eBook Packages: Springer Book Archive