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Prevention of Sudden Death: Role of Antiarrhythmic Therapy

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Selected Topics in Preventive Cardiology

Part of the book series: Ettore Majorana International Science Series ((SIPC))

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Abstract

Currently it is estimated there are about 600,000 cardiac deaths per year in the United States1. Of these 400,000 are relatively sudden, i.e. unexpected and rapid, amounting to 1,200 per day and therefore almost 1 per minute. Half of these “sudden” deaths occur within one hour from the onset of symptoms and many of these are truly sudden, i.e. instantaneous. This is notably a “disease” of men with up to 4 times the incidence in women. Indeed, in young and middle-aged men it is the leading cause of death - amounting to about 1/3 of deaths.

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References

  1. B. Lown, Sudden cardiac death: The major challenge confronting contemporary cardiology. Am. J. Cardiol. 43:313–328, (1979).

    Article  Google Scholar 

  2. B. Lown and R. B. Graboys, Management of patients with malignant ventricular arrhythmias. Am. J. Cardiol. 39:910–918 (1977).

    Article  Google Scholar 

  3. D. H. Spodick, Effective management of congestive cardiomyopathy: Relation to ventricular structure and function. Arch. Inter. Med. 142:689–692 (1982).

    Article  Google Scholar 

  4. S. Goldstein, R. Landis, R. Leighton, G. Ritter, C. M. Vasu, A. Lantis and R. Serokman, Characteristics of the resuscitated out-of-hospital cardiac arrest victim with coronary heart disease. Circulation 64:977–984 (1981).

    Article  Google Scholar 

  5. L. E. Hinkle and H. T. Thaler, Clinical classification of cardiac death. Circulation 65:457–464 (1982).

    Article  Google Scholar 

  6. R. J. Myerburg, C. A. Conde, S. J. Sung, A. Mayorga-Cortes, S. M. Mallon, D. S. Sheps, R. A. Appel and A. Castellanos, Clinical, electrophysiologic and hemodynamic profile of patients resuscitated from prehospital cardiac arrest. Am. J. Med. 68:568–576 (1980).

    Article  Google Scholar 

  7. A. A. J. Adgey, J. E. Devlin, S. W. Webb and H. C. Mulholland, Initiation of ventricular fibrillation outside hospital in patients with acute ischaemic heart disease. Br. Heart J. 47: 55–61 (1982).

    Article  Google Scholar 

  8. R. J. Myerburg, L. Zaman, K. M. Kessler and A. Castellanos, Evolving concepts of management of stable and potentially lethal arrhythmias. Am. Heart J. 183:615–625 (1982).

    Article  Google Scholar 

  9. S. Goldstein, Necessity of a uniform definition of sudden coronary death: Witnessed death within 1 hour of the onset of acute symptoms. Am. Heart J. 103:156–159 (1982).

    Article  Google Scholar 

  10. W. Ruberman, E. Weinblat, C. W. Frank, J. S. Goldbert and S. Shapiro, Repeated 1 hour electrocardiographic monitoring of survivors of myocardial infarction at 6 month intervals: Arrhythmia detection and relation to prognosis. Am. J. Cardiol. 47:1197–1204 (1981).

    Article  Google Scholar 

  11. A. J. Moss, H. T. Davis, J. DeCamilla and L. W. Bayer, Ventricular ectopic beats and their relation to sudden and nonsudden cardiac death after myocardial infarction. Circulation 60:998–1003 (1979).

    Google Scholar 

  12. W. Ruberman, E. Weinblatt, J. D. Goldbert and S. W. Frank, Sudden death after myocardial infarction: Runs of ventricular premature beats and R-on-T as high risk factors. Am. J. Cardiol. 45:444 (1980).

    Article  Google Scholar 

  13. H. L. Greene, P. R. Reid and A. H. Schaeffer: The repetitive ventricular response in man. New Engl. J. Med. 299:729–734 (1978).

    Article  Google Scholar 

  14. G. J. Taylor, J. O. O’Neal, B. Pitt, S. C. Griffith and S. C. Achuff, Complex ventricular arrhythmias after myocardial infarction during convalescence and follow-up: A Harbinger oli multi-vessel coronary disease, left ventricular dysfunction and sudden death. John Hopkins Med. J. 149:1–5 (1981).

    Google Scholar 

  15. T. Sugiura, A. P. Flessas, J. S. Singh and D. H. Spodick, Ventricular arrhythmias in the late hospital phase of acute myocardial infarction. Circulation 64(IV) IV-306 (1981).

    Google Scholar 

  16. J. N. Ruskin, J. P. DiMarco and H. Garan, Out-of-hospital cardiac arrest. Electrophysiologic observations and selection of longterm antiarrhythmic therapy. New Engl. J. Med. 303:607–613 (1980).

    Article  Google Scholar 

  17. J. P. VanDurme, M. G. Bogaert, Prevention of sudden death: Role of antiarrhythmic therapy. In: H. E. Kulbertus and H. J. J. Wellens, Sudden Death, DenJuag, Nijhoff, pp 324–327 (1980).

    Chapter  Google Scholar 

  18. R. J. Myerburg, F. W. Briese, C. Conde, S. M. Mallon, R. R. Liberthson and A. Castellanos: Long-term antiarrhythmic therapy in survivors of prehospital cardiac arrest. Initial 18 months experience. JAMA 238:2621–2624 (1977).

    Article  Google Scholar 

  19. J. R. Hampton and M. A. D. Phil, Beta-blockade and the secondary prevention of myocardial infarction. Acta Med. Scand. Supple 651: 219–226 (1981).

    Google Scholar 

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© 1983 Plenum Press, New York

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Spodick, D.H. (1983). Prevention of Sudden Death: Role of Antiarrhythmic Therapy. In: Raineri, A., Kellermann, J.J. (eds) Selected Topics in Preventive Cardiology. Ettore Majorana International Science Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3736-2_12

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  • DOI: https://doi.org/10.1007/978-1-4613-3736-2_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3738-6

  • Online ISBN: 978-1-4613-3736-2

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