Abstract
The phenomenon of Ir gene control of immune responsiveness is intimately related to the fact that antigen-specific stimulation of T cells with the Lyt-1 surface phenotype requires the simultaneous recognition of both external antigen and Ia antigen on the surface of antigen-presenting cells. There is increasing evidence indicating that Ia antigens encoded for by the I-A and I-E/C subregions of the H-2 complex represent the products of Ir genes.
This work was supported by a grant of the Deutsche Forschungs-gemeinschaft, SFB 107. Part of this study was carried out by E.S. in partial fulfilment of the requirements for a doctoral thesis at the University of Mainz.
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© 1983 Plenum Press, New York
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Rüde, E., Reske-Kunz, A.B., Spaeth, E. (1983). Specificity and Restriction of T Cells in a System of Complementing Ir Genes. In: Celada, F., Schumaker, V.N., Sercarz, E.E. (eds) Protein Conformation as an Immunological Signal. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3778-2_39
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