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Peptides Containing Probable Transmitter Candidates in the Central Nervous System

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Peptides in Neurobiology

Part of the book series: Current Topics in Neurobiology ((CTNB))

Abstract

Peptides in the CNS are characterized by their (1) low overall concentrations, (2) high potency, (3) marked specificity, (4) both transmitter and hormonal-like properties, (5) content of potential transmitter candidates, and (6) apparent low rate of de novo synthesis in vitro.

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References

  • Barker, L., and Gainer, H., 1974, Peptide regulation of bursting pacemaker activity in a molluscan neurosecretory cell, Science 184:1371–1373.

    Article  PubMed  CAS  Google Scholar 

  • Barnea, A., Ben-Jonathan, N., Colston, C., Johnston, J.M., and Porter, J.C., 1975, Differential subcellular compartmentalization of thyrotropin releasing hormone (TRH) and gonadotropin releasing hormone (LRH) in hypothalamic tissue, Proc. Nat. Acad. Sci. U.S.A., 72:3153–3157.

    Article  CAS  Google Scholar 

  • Benuck, M., and Marks, N., 1975, Enzymatic inactivation of substance P by a partially purified enzyme from rat brain, Biochem. Biophys. Res. Commun. 65:153–160.

    Article  PubMed  CAS  Google Scholar 

  • Curatolo, A., D’Arcangelo, P., Lino, A., and Brancati, A., 1965, Distribution of N-acetyl-aspartic and N-acetyl-aspartyl-glutamic acids in nervous tissue, J. Neurochem. 12:339–342.

    Article  PubMed  CAS  Google Scholar 

  • De Wied, D., Bohus, B., and Van Wimersma-Greidanus, T.B., 1975, Memory deficit in rats with hereditary diabetes insipidus, Brain Res. 85:152–156.

    Article  Google Scholar 

  • Edminson, P.D., 1975, Tentative identification of N-acetyl-aspartyl-peptide complexes containing serotonin, or a serotonin derivative, formed in vitro in brain tissue extracts, 10th Meeting of the FEBS Paris (abstract 1291).

    Google Scholar 

  • Fink, G., Smith, G.G., Tibballs, J., and Lee, V.W.K., 1972, LRF and CRF release in subcellular fractions of bovine median eminence, Nature London New Biol. 239:57–59.

    Article  CAS  Google Scholar 

  • Fishman, J., and Norton, B., 1975, Catechol-estrogen formation in the central nervous system of the rat, Endocrinology 96:1054–1059.

    Article  PubMed  CAS  Google Scholar 

  • Garred, P., Gray, J.A., and De Wied, D., 1974, Pituitary-adrenal hormones and extinction of reversal behaviour in the rat, Physiol. Behav. 12:109–119.

    Article  Google Scholar 

  • Garver, D.L., Ghanshyam, N.P., Haroutune, D., and Deleon-Jones, F., 1975, Growth hormone and catecholamines in affective disease, Amer. J. Psychiatry 132:1149–1154.

    CAS  Google Scholar 

  • Ginsburg, M., Wajda, I., and Waelsch, H., 1963, Transglutaminase and histamine incorporation in vivo, Biochem. Pharmacol. 12:251–264.

    Article  PubMed  CAS  Google Scholar 

  • Goodman, R.H., Flexner, J.B., and Flexner, L.B., 1975, The effects of acetooxycyclohexemide on rate of accumulation of cerebral catecholamines from circulating tyrosine as related to its effect on memory, Proc. Nat. Acad. Sci. U.S.A. 72:479–482.

    Article  CAS  Google Scholar 

  • Griffiths, E.C., and Hooper, K.C., 1974, Peptidase activity in different areas of the rat hypothalamus, Acta Endocrinol. 77:10–18.

    PubMed  CAS  Google Scholar 

  • Griffiths, E.C., Hooper, K.C., Hopkinson, C.R.N., 1973, Evidence for an enzymic component in the rat hypothalamus capable of inactivating luteinizing hormone-releasing factor (LRF), Acta Endocrinol. 74:49–55.

    PubMed  CAS  Google Scholar 

  • Griffiths, E.C., Hooper, K.C., Jeffcoate, S.L., and Holland, D.T., 1975a, Peptidases in different areas of the rat brain hypothalamus inactivating luteinizing hormone-releasing hormone (LHRH), Brain Res. 85:161–164.

    Article  PubMed  CAS  Google Scholar 

  • Griffiths, E.C., Hooper, K.C., Jeffcoate, S.L., and Holland, D.T., 1975b, The effects of gonadec-tomy and gonadal steroids on the activity of hypothalamic peptidases inactivating luteinizing hormone-releasing hormone (LH-RH), Brain Res. 88:384–388.

    Article  PubMed  CAS  Google Scholar 

  • Griffiths, E.C., Hooper, K.C., Jeffcoate, S.L., and White, N., 1975c, Peptidases in the rat hypothalamus inactivating thyrotropin-releasing hormone (TRH), Acta Endocrinol. 79: 209–216.

    PubMed  CAS  Google Scholar 

  • Hökfelt, T., Fuxe, K., Johansson, O., Jeffcoate, S., and White, W., 1975, Thyrotropin releasing hormone (TRH), containing nerve terminals in certain brain stem nuclei in the spinal cord, Neurosci. Lett. 1:133–140.

    Article  PubMed  Google Scholar 

  • Hughes, J., 1975, Isolation of an endogenous compound from brain with pharmacological properties similar to morphine, Brain Res. 88:295–308.

    Article  PubMed  CAS  Google Scholar 

  • Hughes, J., Smith, T.W., Kosterlitz, H.W., Fothergill, L.A., Morgan, B.A., and Morris, H.R., 1975, Identification of two related pentapeptides from the brain with potent opiate agonist activity, Nature London 258:577–579.

    Article  PubMed  CAS  Google Scholar 

  • Ifshin, M.S., Gainer, A., and Barker, J.C., 1975, Peptide factor extracted from milluscan ganglia that modulates bursting pacemaker activity, Nature London 254:72, 73.

    Article  PubMed  CAS  Google Scholar 

  • Johansson, K.N.-G., Hooper, F., Sievertsson, H., Currie, B.L., Folkers, K., and Bowers, C.Y., 1972, Biosynthesis in vitro of the luteinizing releasing hormone by hypothalamic tissue, Biochem. Biophys. Res. Commun. 49:656–660.

    Article  PubMed  CAS  Google Scholar 

  • Johansson, K.N.-G., Greibrokk, T., Currie, B.L., Hansen, J., Folkers, K., and Bowers, C.Y., 1975, Factor C-LHIH which inhibits the luteinizing hormone from basal release and from synthetic LHRH and studies on purification of FSHRH, Biochem. Biophys. Res. Commun. 63:62–68.

    Article  PubMed  CAS  Google Scholar 

  • Kumon, A., Matsuoka, Y., Nakajima, T., Kakimoto, T., Imaoka, N., and Sano, I., 1970, Isolation and identification of N α-(β-alanyl) lysine and Nα-(γ-aminobutyryl) lysine from bovine brain, Biochem. Biophys. Acta 200:170, 171.

    PubMed  CAS  Google Scholar 

  • Kvamme, E., Reichelt, K.L., Edminson, P.D., Sinichkin, A., Sterri, S., and Svenneby, G., 1915, N-Substituted peptides in brain, Proceedings of the 10th FEBS Meeting, pp. 127–136.

    Google Scholar 

  • LaBella, F., Dular, R., Vivian, S., and Queen, G., 1973, Pituitary hormone releasing or inhibiting activity of metal ions present in hypothalamic extracts, Biochem. Biophys. Res. Commun. 52:786–791.

    Article  PubMed  CAS  Google Scholar 

  • Mahesh, V.B., Muldoon, T.G., Eldridge, J.C., and Korach, K.S., 1975, The role of steroid hormones in the regulation of gonadotropin secretion, J. Steroid Biochem. 6:1025–1036.

    Article  PubMed  CAS  Google Scholar 

  • Margolis, F.L., 1974, Carnosine in the primary olfactory pathway, Science 184:909–911.

    Article  PubMed  CAS  Google Scholar 

  • Marks, N., 1971, Peptide hydrolases, in: Handbook of Neurochemistry (A. Lajtha, ed.), Vol. 3, pp. 133–171, Plenum Press, New York.

    Google Scholar 

  • Marks, N., Galoyan, A., Grynbaum, A., and Lajtha, A., 1974, Protein and peptide hydrolases of the rat hypothalamus and pituitary, J. Neurochem. 22:735–739.

    Article  PubMed  CAS  Google Scholar 

  • McCann, S.M., and Moss, R.L., 1975, Putative neurotransmitters involved in discharging gonado-tropin-releasing neurohormones and the action of LH-releasing hormone on the CNS, Life Sci. 16:833–852.

    Article  PubMed  CAS  Google Scholar 

  • McKelvy, J.F., Sheridan, M., Joseph, S., Phelphs, C.H., and Perrie, S., 1975, Biosynthesis of thyro-tropin-releasing hormone in organ cultures of the guinea pig median eminence, Endocrinology 97:908–918.

    Article  PubMed  CAS  Google Scholar 

  • Mitnick, M., and Reichlin, S., 1972, Enzymatic synthesis of thyrotropin-releasing hormone (TRH) by hypothalamic TRH synthetase, Endocrinology 91:1145–1153.

    Article  PubMed  CAS  Google Scholar 

  • Monnier, M., and Schoenbergen, G.A.S., 1974, Neuro-humoral coding of sleep by the physiological sleep factor delta, in: Neurochemical Coding of Brain Function (R.D. Myers and R.R. Drucker, eds.), Odin, New York.

    Google Scholar 

  • Ojeda, S.L., Wheaton, J.E., and McCann, S.M., 1975, Prostaglandin E2 induced release of luteinizing hormone-releasing factor (LRF), Neuroendocrinology 17:283–287.

    Article  PubMed  CAS  Google Scholar 

  • Ondo, J.G., 1974, Gamma-aminobutyric acid effects on pituitary gonadotropin secretion, Science 186:738, 739.

    Article  PubMed  CAS  Google Scholar 

  • Otsuka, M., Konishi, S., and Takahashi, T., 1975, Hypothalamic substance P as a candidate for transmitter of primary afferent neurons, Fed. Proc. Fed. Amer. Soc. Exp. Biol. 34:1922–1928.

    CAS  Google Scholar 

  • Pisano, J.J., Wilson, J.D., Cohen, L., Abraham, D., and Udenfriend, S., 1961, Isolation of γ-aminobutyryl-histidine (homocarnosine) from brain, J. Biol. Chem. 236:499–502.

    PubMed  CAS  Google Scholar 

  • Reichelt, K.L., 1970, The isolation of gamma-glutamyl peptides from monkey brain, J. Neurochem. 17:19–25.

    Article  PubMed  CAS  Google Scholar 

  • Reichelt, K.L., 1972, An Investigation into the Nature and Function of Anionic Acids, Peptides, and Acid-Soluble Proteins from Brain Tissue, pp. 1–42, Oslo Univ. Press, Oslo.

    Google Scholar 

  • Reichelt, K.L., and Edminson, P.D., 1974, Biogenic amine specificity of cortical peptide synthesis in monkey brain, FEBS Lett. 47:185–189.

    Article  PubMed  CAS  Google Scholar 

  • Reichelt, K.L., and Edminson, P.D., 1976, Transmitter dependent peptide synthesis in the CNS, in: Advances in Biochemical Neuropharmacology, pp. 211–223, Raven Press, New York.

    Google Scholar 

  • Reichelt, K.L., and Kvamme, E., 1973, Histamine-dependent formation of N-acetyl-aspartyl peptides in mouse brain, J. Neurochem. 21:849–859.

    Article  PubMed  CAS  Google Scholar 

  • Reichelt, K.L., Edminson, P.D., and Kvamme, E., 1976, The formation of peptido-amines from constituent amino acids and histamine in nervous tissue, J. Neurochem. 26:811–815.

    Article  PubMed  CAS  Google Scholar 

  • Renaud, L.P., Martin, J.B., and Brazeau, P., 1975, Depressant action of TRH, LH-RH and somatostatin on activity of central neurones, Nature 255:233–235.

    Article  PubMed  CAS  Google Scholar 

  • Sano, I., Kakimoto, Y., Kanazawa, A., Nakajima, T., and Schimizu, M., 1966, Identifizierung einiger Glutamyl Peptide aus Gehirn, J. Neurochem. 13:711–719.

    Article  PubMed  CAS  Google Scholar 

  • Schally, A.V., Arimura, A., and Kastin, A.J., 1973, Hypothalamic regulatory hormones, Science 179:341–350.

    Article  PubMed  CAS  Google Scholar 

  • Sherrington, C.S., 1906, The Integrative Action of the Nervous System, Yale Univ. Press, New Haven.

    Google Scholar 

  • Skaper, S.D., Das, S., and Marshall, F.D., 1973, Some properties of a homocarnosine-carnosine synthetase isolated from rat brain, J. Neurochem. 21:1429–1445.

    Article  PubMed  CAS  Google Scholar 

  • Sobue, K., Konishi, H., and Nakayima, T., 1975, Isolation and identification of N-acetyl-homocar- nosine and N-acetyl-carnosine from brain and muscle, J. Neurochem. 24:1261, 1262.

    Article  PubMed  CAS  Google Scholar 

  • Ungar, G., 1974, Molecular coding of memory, Life Sciences 14:595–604.

    Article  PubMed  CAS  Google Scholar 

  • Ungar, G., Desiderio, D.M., and Parr, W., 1972, Isolation, identification of a specific behaviour inducing peptide, Nature London 238:198–202.

    Article  PubMed  CAS  Google Scholar 

  • Van Wimersma-Greidanus, T.B., Bohus, B., and De Wied, D., 1975, The role of vasopressin in memory consolidation, J. Endocrinol. 164:30, 31.

    Google Scholar 

  • Winokur, A., and Utiger, R.D., 1974, Thyrotropin-releasing hormone: Regional distribution in rat brain, Science 185:265–267.

    Article  PubMed  CAS  Google Scholar 

  • Wise, C.D., Berger, B.D., and Stein, L., 1973,Evidence for α-noradrenergic reward receptors and serotonergic punishment receptors in rat brain, Biol. Psychiatry 6:3–21.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neurochemistry, The University Psychiatric Clinic, Vinderen, Oslo, Norway

    K. L. Reichelt & P. D. Edminson

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  1. K. L. Reichelt
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  2. P. D. Edminson
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Editors and Affiliations

  1. Section on Functional Neurochemistry, Behavioral Biology Branch, National Institute of Child Health and Human Development, National Institutes of Health, 20014, Bethesda, Maryland, USA

    Harold Gainer

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© 1977 Plenum Press, New York

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Reichelt, K.L., Edminson, P.D. (1977). Peptides Containing Probable Transmitter Candidates in the Central Nervous System. In: Gainer, H. (eds) Peptides in Neurobiology. Current Topics in Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4130-7_7

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  • DOI: https://doi.org/10.1007/978-1-4613-4130-7_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4132-1

  • Online ISBN: 978-1-4613-4130-7

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