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Uptake of Transmitter Candidates as an Approach to their Localization

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Metabolic Compartmentation and Neurotransmission

Abstract

Nerve endings in the brain possess membrane transport mechanisms for the uptake of various substances. The compounds thought to act as transmitters characteristically are taken up by high-affinity mechanisms (Table I) (Iversen, 1971; Snyder et al., 1970, 1973). These mechanisms are highly specific and are dependent on temperature and on a high concentration of sodium ions. They are also sensitive to inhibition of energy production or of Na, K-ATPase (see Kuhar, 1973, for references).

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Author information

Authors and Affiliations

  1. Division of Toxicology, Norwegian Defence Research Establishment, Kjeller, Norway

    Jon Storm-Mathisen

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  1. Jon Storm-Mathisen
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Editors and Affiliations

  1. Mt. Sinai School of Medicine, New York, New York, USA

    Soll Berl

  2. Fordham University, Bronx, New York, USA

    D. D. Clarke

  3. Neurosciences Research Program, Boston, Massachusetts, USA

    Diana Schneider

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© 1975 Plenum Press, New York

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Storm-Mathisen, J. (1975). Uptake of Transmitter Candidates as an Approach to their Localization. In: Berl, S., Clarke, D.D., Schneider, D. (eds) Metabolic Compartmentation and Neurotransmission. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4319-6_7

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  • DOI: https://doi.org/10.1007/978-1-4613-4319-6_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4321-9

  • Online ISBN: 978-1-4613-4319-6

  • eBook Packages: Springer Book Archive

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