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Engineering Fibrous Tissues and Their Interfaces with Bone

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Abstract

Tendons and ligaments facilitate movement and provide stability to joints in the human body. However, current surgical treatments for fibrous tissue injuries, such as tissue grafts, pose problems of donor site morbidity (autografts) or potential for pathogen transfer (allografts). Tissue engineering techniques are being investigated to overcome current clinical challenges to regenerate injured fibrous tissues and their interfaces. This chapter discusses the basic structure and function of fibrous tissues, as well as tissue engineering methods using cells, scaffolds, and exogenous factors, to recreate both tendons/ligaments and their interfaces with surrounding bone.

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Acknowledgments

The authors would like to thank Dr. Yongzhi Qiu and Dr. Peter J. Yang for their contributions to the figures depicted in this chapter.

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Authors and Affiliations

  1. George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA

    Jennifer Lei

  2. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA

    Johnna S. Temenoff

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  1. Jennifer Lei
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  2. Johnna S. Temenoff
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Correspondence to Johnna S. Temenoff .

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Editors and Affiliations

  1. , Department of Orthopedic Surgery, Washington University, South Euclid 660, St. Louis, 63110, Missouri, USA

    Stavros Thomopoulos

  2. , Engineering Education Center, Missouri University of Science and Tech., University Blvd. One, St. Louis, 63121, Missouri, USA

    Victor Birman

  3. , Mechanical Engineering, Washington University, 1 Brookings Drive, St. Louis, 63130, Missouri, USA

    Guy M. Genin

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Lei, J., Temenoff, J.S. (2013). Engineering Fibrous Tissues and Their Interfaces with Bone. In: Thomopoulos, S., Birman, V., Genin, G. (eds) Structural Interfaces and Attachments in Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3317-0_15

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  • DOI: https://doi.org/10.1007/978-1-4614-3317-0_15

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