Abstract
We report here on the synthesis of a novel Molecularly Imprinted Polymer (MIP) against the neurotransmitter serotonin on pre-formed SiO2 nanobeads by surface imprinting via reversible addition-fragmentation chain-transfer (RAFT) polymerization. The as-synthesized core-shell Ser-MIP@SiO2 nanobeads were integrated onto electrode surfaces to develop advanced electrochemical sensors for this analyte. The successful immobilization of Ser-MIP@SiO2 nanobeads was carried out by the electropolymerization of either o-phenylenediamine (OPD) or ethylenedioxythiophene (EDOT) and preliminary results on the sensing capability of the novel modified electrodes were also achieved.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Sellergren B (2001) Molecularly imprinted polymers man-made mimics of antibodies and their applications in analytical chemistry. Elsevier, Amsterdam
Mahony JO et al (2005) Molecularly imprinted polymers – potential and challenges in analytical chemistry. Anal Chim Acta 534:31–39
Piletsky SA, Turner APF (2002) Electrochemical sensors based on molecularly imprinted polymers. Electroanalysis 14:317–323
Malitesta C, Mazzotta E, Picca RA, Poma A, Chianella I, Piletsky SA (2012) MIP sensors – the electrochemical approach. Anal Bioanal Chem 402:1827–1846
Titirici M-M, Sellergren B (2006) Thin molecularly imprinted polymer films via reversible addition-fragmentation chain transfer polymerization. Chem Mater 18:1773–1779
Lu C-H et al (2007) Surface-imprinted core-shell nanoparticles for sorbent assays. Anal Chem 79:5457–5461
Chattopadhyay A, Rukmini R, Mukherjee S (1996) Photophysics of a neurotransmitter: ionization and spectroscopic properties of serotonin. Biophys J 71:1952–1960
Mazzotta E, Picca RA, Malitesta C, Piletsky SA, Piletska EV (2008) Development of a sensor prepared by entrapment of MIP particles in electrosynthesised polymer films for electrochemical detection of ephedrine. Biosens Bioelectron 23:152–156
Li C, Han J, Ryu CY, Benicewicz BC (2006) A versatile method to prepare RAFT agent anchored substrates and the preparation of PMMA grafted nanoparticles. Macromolecules 39:3175–3183
Acknowledgments
Vigoni programme (Bando 2009) is gratefully acknowledged for financial support.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media New York
About this paper
Cite this paper
Picca, R.A., Malitesta, C., Mohammadi, R., Ghorbani, F., Sellergren, B. (2014). Novel Format of Molecularly Imprinted Polymers for the Development of Electrochemical Sensors. In: Baldini, F., et al. Sensors. Lecture Notes in Electrical Engineering, vol 162. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3860-1_29
Download citation
DOI: https://doi.org/10.1007/978-1-4614-3860-1_29
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-3859-5
Online ISBN: 978-1-4614-3860-1
eBook Packages: EngineeringEngineering (R0)