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Diabetes and Cardiac Mitochondria

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Mitochondria and Their Role in Cardiovascular Disease

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Abstract

Heart failure is common in patients with diabetes, even in the absence of coronary artery disease or hypertension. Diabetic cardiomyopathy is one of the leading causes of heart failure among diabetic patients. Metabolism of myocardium is altered in diabetes, which likely contributes to decreased contractile activity and ventricular failure. The mitochondria play a major role in cellular metabolism, and there is evidence indicating that mitochondrial dysfunction is critical in the pathogenesis of diabetic cardiomyopathy.

Up to 1 % of patients with diabetes are affected by maternally inherited diabetes caused by genetic abnormalities in mitochondrial DNA. Several mitochondrial DNA mutations not only are associated with mitochondrial diabetes but also are a cause of the developing cardiomyopathy.

In this chapter we will focus on the effects of diabetes on cardiac myocardium with specific reference to the role of modulation of cardiac mitochondrial function in the disease process. Several potential mechanisms that lead to mitochondrial dysfunction in the diabetic heart will be discussed.

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  1. The Molecular Cardiology and Neuromuscular Institute, Highland Park, NJ, USA

    José Marín-García M.D.

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Marín-García, J. (2013). Diabetes and Cardiac Mitochondria. In: Mitochondria and Their Role in Cardiovascular Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4599-9_20

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