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Mesenchymal Lesions of the Urinary Bladder

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The Urinary Tract

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Abstract

Proliferations of mesenchymal cells, which are mesoderm-derived cells that form connective tissues, are uncommon in the urinary bladder. The majority of these lesions are comprised of cells with myofibroblastic, smooth muscle, or skeletal muscle lineage. Urothelial carcinomas may also rarely have a spindle cell histology that closely mimic mesenchymal cells, and in some cases specific lines of true mesenchymal differentiation such as chondrosarcoma may be present (i.e., carcinosarcoma). This spectrum of mesenchymal lesions may be diagnostically challenging for pathologists due to the degree of histologic overlap between clinically benign and malignant lesions. In some instances, the number of different diagnostic terms that have been applied to the same lesion has added unnecessary confusion for urologists and pathologists alike. Finally, given the rarity of this spectrum of lesions, there are often little data available to help guide therapeutic decision-making. We discuss these diagnostic and treatment issues related to mesenchymal lesions of the urinary bladder in this chapter.

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Authors and Affiliations

  1. Department of Pathology, Stanford University Medical Center, 300 Pasteur Drive, H2110, Stanford, CA, 94025, USA

    Jesse K. McKenney & Mark L. Gonzalgo

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  1. Jesse K. McKenney
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  2. Mark L. Gonzalgo
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Correspondence to Jesse K. McKenney .

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Editors and Affiliations

  1. Department of Pathology, Cleveland Clinic, Cleveland, 44195, Ohio, USA

    Donna E. Hansel

  2. Department of Pathology, Stanford University Medical Center, Stanford, 94305, California, USA

    Jesse K. McKenney

  3. Glickman Urologic and Kidney Institute, Section of Urologic Oncology, Cleveland Clinic, Cleveland, 44195, Ohio, USA

    Andrew J. Stephenson

  4. Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, 37232-2765, Tennessee, USA

    Sam S. Chang

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McKenney, J.K., Gonzalgo, M.L. (2012). Mesenchymal Lesions of the Urinary Bladder. In: Hansel, D., McKenney, J., Stephenson, A., Chang, S. (eds) The Urinary Tract. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5320-8_12

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