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The Tyr-Tyr-Arg Prion-Specific Epitope: Update and Context

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Prions and Diseases

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Abstract

The production of PrPSc-specific antibodies has proven challenging, but much has been learned since the production of the first PrPSc-specific antibody in 1997 by Korth and colleagues. Some of the challenges that have been overcome, and the novel approaches that have been applied over the past 15 years will be reviewed and presented in this summary of prion immunology.

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  1. Brain Research Centre, University of British Columbia, Vancouver, BC, Canada

    T. Dean Airey & Neil R. Cashman M.D.

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  1. T. Dean Airey
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  2. Neil R. Cashman M.D.
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Correspondence to Neil R. Cashman M.D. .

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  1. , Department of Pathology, Case Western Reserve University School o, 2085 Adelbert Road, Cleveland, 44106, Ohio, USA

    Wen-Quan Zou

  2. , Department of Neuropathology, Case Western Reserve University School o, 2085 Adelbert Road, Cleveland, 44106, Ohio, USA

    Pierluigi Gambetti

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Airey, T.D., Cashman, N.R. (2013). The Tyr-Tyr-Arg Prion-Specific Epitope: Update and Context. In: Zou, WQ., Gambetti, P. (eds) Prions and Diseases. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5338-3_15

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