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Parathyroid Hormone: A Dynamic Regulator of Bone, Immune, and Hematopoietic Cells

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Osteoimmunology

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Abstract

Parathyroid hormone (PTH) is an endocrine mediator circulating from the parathyroid gland to its primary target organs bone and kidney to regulate calcium homeostasis via the parathyroid hormone/parathyroid hormone-related protein receptor (PPR). The actions of PTH in bone have focused mainly on its role in stimulating osteoclastogenesis via indirectly targeting cells of the osteoclast lineage as well as its role in stimulating bone formation via increasing osteoblast numbers. Less well characterized but a vital part of PTH actions is its role in modulating other cells of the hematopoietic lineage in the bone marrow microenvironment. With the current pharmacologic use of the amino terminal PTH 1–34 analogue (teriparatide) in the management of osteoporosis, there is increasing interest to elucidate novel functions of PTH in the bone marrow microenvironment. In this review, current understanding of the interaction between PTH and hematopoietic lineage cells including osteoclasts, lymphocytes, and hematopoietic stem cells is summarized and the physiologic relevance and therapeutic potential of the immunomodulatory function of PTH in humans is discussed.

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  1. Department of Periodontics and Oral Medicine, Medical School, University of Michigan, Ann Arbor, MI, 48109-1078, USA

    Sun Wook Cho & Laurie McCauley

  2. Pathology Department, Medical School, University of Michigan, Ann Arbor, MI, 48109-1078, USA

    Laurie McCauley

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  1. School of Medicine, Dept. Pathology & Lab. Medicine, University of Pennsylvania, Curie Blvd., Philadelphia, 19104, Pennsylvania, USA

    Yongwon Choi

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Cho, S.W., McCauley, L. (2013). Parathyroid Hormone: A Dynamic Regulator of Bone, Immune, and Hematopoietic Cells. In: Choi, Y. (eds) Osteoimmunology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5366-6_7

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