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Quantitative CT Imaging of Carotid Arteries

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Multi-Modality Atherosclerosis Imaging and Diagnosis

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Abstract

Noninvasive imaging techniques provide a window to atherosclerotic disease in vivo. Multidetector CT angiography represents a potential clinical tool to monitor carotid atherosclerosis, since it is a robust, readily available, and fast technique and it enables (semi)automated quantification of luminal measures as well as of plaque burden and plaque composition. This chapter reviews the state-of-the-art CTA technique used to evaluate carotid artery stenosis and atherosclerotic plaque.

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References

  1. Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM, Carnethon MR, Dai S, de Simone G, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Greenlund KJ, Hailpern SM, Heit JA, Ho PM, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, McDermott MM, Meigs JB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Rosamond WD, Sorlie PD, Stafford RS, Turan TN, Turner MB, Wong ND, Wylie-Rosett J, American Heart Association Statistics Committee and Stroke Statistics Subcommittee (2011) Heart disease and stroke statistics – 2011 update: a report from the American Heart Association. Circulation 123(4):e18–e209. doi:10.1161/CIR.0b013e3182009701, CIR.0b013e3182009701 [pii]

    Article  PubMed  Google Scholar 

  2. Warlow C, Sudlow C, Dennis M, Wardlaw J, Sandercock P (2003) Stroke. Lancet 362(9391):1211–1224. doi:10.1016/S0140-6736(03)14544-8, S0140-6736(03)14544-8 [pii]

    Article  PubMed  Google Scholar 

  3. (1991) Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med 325(7):445–453. doi:10.1056/NEJM199108153250701

  4. (1998) Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet 351(9113):1379–1387. doi:S0140673697092921 [pii]

    Google Scholar 

  5. Rothwell PM, Eliasziw M, Gutnikov SA, Fox AJ, Taylor DW, Mayberg MR, Warlow CP, Barnett HJ, Carotid Endarterectomy Trialists C (2003) Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis. Lancet 361(9352):107–116, doi:S0140673603122283 [pii]

    Article  PubMed  CAS  Google Scholar 

  6. (1995) Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. JAMA 273(18):1421–1428

    Google Scholar 

  7. Halliday A, Mansfield A, Marro J, Peto C, Peto R, Potter J, Thomas D, Group MRCACSTC (2004) Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial. Lancet 363(9420):1491–1502. doi:10.1016/S0140-6736(04)16146-1, S0140673604161461 [pii]

    Article  PubMed  CAS  Google Scholar 

  8. Hobson RW 2nd, Weiss DG, Fields WS, Goldstone J, Moore WS, Towne JB, Wright CB (1993) Efficacy of carotid endarterectomy for asymptomatic carotid stenosis. The Veterans Affairs Cooperative Study Group. N Engl J Med 328(4):221–227. doi:10.1056/NEJM199301283280401

    Article  PubMed  Google Scholar 

  9. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Juhani Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W Jr, Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK, Willerson JT (2003) From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I. Circulation 108(14):1664–1672. doi:10.1161/01.CIR.0000087480.94275.97 , 108/14/1664 [pii]

    Article  PubMed  Google Scholar 

  10. Lovett JK, Gallagher PJ, Hands LJ, Walton J, Rothwell PM (2004) Histological correlates of carotid plaque surface morphology on lumen contrast imaging. Circulation 110(15):2190–2197. doi:10.1161/01.CIR.0000144307.82502.32, 01.CIR.0000144307.82502.32 [pii]

    Article  PubMed  CAS  Google Scholar 

  11. Eliasziw M, Streifler JY, Fox AJ, Hachinski VC, Ferguson GG, Barnett HJ (1994) Significance of plaque ulceration in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial. Stroke 25(2):304–308

    Article  PubMed  CAS  Google Scholar 

  12. Rothwell PM, Gibson R, Warlow CP (2000) Interrelation between plaque surface morphology and degree of stenosis on carotid angiograms and the risk of ischemic stroke in patients with symptomatic carotid stenosis. On behalf of the European Carotid Surgery Trialists’ Collaborative Group. Stroke 31(3):615–621

    Article  PubMed  CAS  Google Scholar 

  13. Hankey GJ, Warlow CP, Molyneux AJ (1990) Complications of cerebral angiography for patients with mild carotid territory ischaemia being considered for carotid endarterectomy. J Neurol Neurosurg Psychiatry 53(7):542–548

    Article  PubMed  CAS  Google Scholar 

  14. Willinsky RA, Taylor SM, TerBrugge K, Farb RI, Tomlinson G, Montanera W (2003) Neurologic complications of cerebral angiography: prospective analysis of 2,899 procedures and review of the literature. Radiology 227(2):522–528. doi:10.1148/radiol.2272012071, 2272012071 [pii]

    Article  PubMed  Google Scholar 

  15. Saba L, Anzidei M, Sanfilippo R, Montisci R, Lucatelli P, Catalano C, Passariello R, Mallarini G (2011) Imaging of the carotid artery. Atherosclerosis 220(2):294–309. doi:10.1016/j.atherosclerosis.2011.08.048, S0021-9150(11)00852-5 [pii]

    Article  PubMed  Google Scholar 

  16. European Society of Radiology (2010) White paper on imaging biomarkers. Insights Imaging 1:42–45. doi:10.1007/s13244-010-0025-8

    Article  Google Scholar 

  17. Beitzke D, Wolf F, Edelhauser G, Plank C, Schernthaner R, Weber M, Nolz R, Lammer J, Loewe C (2011) Computed tomography angiography of the carotid arteries at low kV settings: a prospective randomised trial assessing radiation dose and diagnostic confidence. Eur Radiol 21(11):2434–2444. doi:10.1007/s00330-011-2188-1

    Article  PubMed  Google Scholar 

  18. Cademartiri F, van der Lugt A, Luccichenti G, Pavone P, Krestin GP (2002) Parameters affecting bolus geometry in CTA: a review. J Comput Assist Tomogr 26(4):598–607, doi:00004728-200207000-00022 [pii]

    Article  PubMed  Google Scholar 

  19. de Monye C, de Weert TT, Zaalberg W, Cademartiri F, Siepman DA, Dippel DW, van der Lugt A (2006) Optimization of CT angiography of the carotid artery with a 16-MDCT scanner: craniocaudal scan direction reduces contrast material-related perivenous artifacts. AJR Am J Roentgenol 186(6):1737–1745. doi:10.2214/AJR.05.0143, 186/6/1737 [pii]

    Article  PubMed  Google Scholar 

  20. Liu Y, Hopper KD, Mauger DT, Addis KA (2000) CT angiographic measurement of the carotid artery: optimizing visualization by manipulating window and level settings and contrast material attenuation. Radiology 217(2):494–500

    PubMed  CAS  Google Scholar 

  21. de Weert TT, Ouhlous M, Zondervan PE, Hendriks JM, Dippel DW, van Sambeek MR, van der Lugt A (2005) In vitro characterization of atherosclerotic carotid plaque with multidetector computed tomography and histopathological correlation. Eur Radiol 15(9):1906–1914. doi:10.1007/s00330-005-2712-2

    Article  PubMed  Google Scholar 

  22. van Straten M, Venema HW, Streekstra GJ, Majoie CB, den Heeten GJ, Grimbergen CA (2004) Removal of bone in CT angiography of the cervical arteries by piecewise matched mask bone elimination. Med Phys 31(10):2924–2933

    Article  PubMed  Google Scholar 

  23. Venema HW, Hulsmans FJ, den Heeten GJ (2001) CT angiography of the circle of Willis and intracranial internal carotid arteries: maximum intensity projection with matched mask bone elimination-feasibility study. Radiology 218(3):893–898

    PubMed  CAS  Google Scholar 

  24. Uotani K, Watanabe Y, Higashi M, Nakazawa T, Kono AK, Hori Y, Fukuda T, Kanzaki S, Yamada N, Itoh T, Sugimura K, Naito H (2009) Dual-energy CT head bone and hard plaque removal for quantification of calcified carotid stenosis: utility and comparison with digital subtraction angiography. Eur Radiol 19(8):2060–2065. doi:10.1007/s00330-009-1358-x

    Article  PubMed  Google Scholar 

  25. Elgersma OE, Buijs PC, Wust AF, van der Graaf Y, Eikelboom BC, Mali WP (1999) Maximum internal carotid arterial stenosis: assessment with rotational angiography versus conventional intraarterial digital subtraction angiography. Radiology 213(3):777–783

    PubMed  CAS  Google Scholar 

  26. Koelemay MJ, Nederkoorn PJ, Reitsma JB, Majoie CB (2004) Systematic review of computed tomographic angiography for assessment of carotid artery disease. Stroke 35(10):2306–2312. doi:10.1161/01.STR.0000141426.63959.cc, 01.STR.0000141426.63959.cc [pii]

    Article  PubMed  Google Scholar 

  27. Hollingworth W, Nathens AB, Kanne JP, Crandall ML, Crummy TA, Hallam DK, Wang MC, Jarvik JG (2003) The diagnostic accuracy of computed tomography angiography for traumatic or atherosclerotic lesions of the carotid and vertebral arteries: a systematic review. Eur J Radiol 48(1):88–102, doi:S0720048X03002006 [pii]

    Article  PubMed  Google Scholar 

  28. Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, Lijmer JG, Moher D, Rennie D, de Vet HC, Standards for Reporting of Diagnostic Accuracy (2003) Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. Clin Radiol 58(8):575–580, doi:S0009926003002587 [pii]

    Article  PubMed  CAS  Google Scholar 

  29. Wardlaw JM, Chappell FM, Best JJ, Wartolowska K, Berry E, NHS Research and Development Health Technology Assessment Carotid Stenosis Imaging Group (2006) Non-invasive imaging compared with intra-arterial angiography in the diagnosis of symptomatic carotid stenosis: a meta-analysis. Lancet 367(9521): 1503–1512. doi:10.1016/S0140-6736(06)68650-9, S0140-6736 (06)68650-9 [pii]

    Article  PubMed  CAS  Google Scholar 

  30. Chappell FM, Wardlaw JM, Young GR, Gillard JH, Roditi GH, Yip B, Pell JP, Rothwell PM, Brown MM, Gough MJ, Randall MS (2009) Carotid artery stenosis: accuracy of noninvasive tests – individual patient data meta-analysis. Radiology 251(2):493–502. doi:10.1148/radiol.2512080284, 2512080284 [pii]

    Article  PubMed  Google Scholar 

  31. Josephson SA, Bryant SO, Mak HK, Johnston SC, Dillon WP, Smith WS (2004) Evaluation of carotid stenosis using CT angiography in the initial evaluation of stroke and TIA. Neurology 63(3):457–460, doi:63/3/457 [pii]

    Article  PubMed  CAS  Google Scholar 

  32. Hacklander T, Wegner H, Hoppe S, Danckworth A, Kempkes U, Fischer M, Mertens H, Caldwell JH (2006) Agreement of multislice CT angiography and MR angiography in assessing the degree of carotid artery stenosis in consideration of different methods of postprocessing. J Comput Assist Tomogr 30(3):433–442, doi:00004728-200605000-00014 [pii]

    Article  PubMed  Google Scholar 

  33. Howard P, Bartlett ES, Symons SP, Fox AJ, Aviv RI (2010) Measurement of carotid stenosis on computed tomographic angiography: reliability depends on postprocessing technique. Can Assoc Radiol J 61(3):127–132. doi:10.1016/j.carj.2009.10.013, S0846-5371(09)00220-4 [pii]

    Article  PubMed  Google Scholar 

  34. Puchner S, Popovic M, Wolf F, Reiter M, Lammer J, Bucek RA (2009) Multidetector CTA in the quantification of internal carotid artery stenosis: value of different reformation techniques and axial source images compared with selective carotid arteriography. J Endovasc Ther 16(3):336–342. doi:10.1583/08-2636.1, 08-2636 [pii]

    Article  PubMed  Google Scholar 

  35. Kirbas C, Quek F (2004) A review of vessel extraction techniques and algorithms. ACM Comput Surv 36(2):81–121. doi:10.1145/1031120.1031121

    Article  Google Scholar 

  36. Lesage D, Angelini ED, Bloch I, Funka-Lea G (2009) A review of 3D vessel lumen segmentation techniques: models, features and extraction schemes. Med Image Anal 13(6):819–845. doi:10.1016/j.media.2009.07.011, S1361-8415(09)00067-X [pii]

    Article  PubMed  Google Scholar 

  37. Manniesing R, Schaap M, Rozie S, Hameeteman R, Vukadinovic D, van der Lugt A, Niessen W (2010) Robust CTA lumen segmentation of the atherosclerotic carotid artery bifurcation in a large patient population. Med Image Anal 14(6):759–769. doi:10.1016/j.media.2010.05.001, S1361-8415(10)00046-0 [pii]

    Article  PubMed  Google Scholar 

  38. Manniesing R, Viergever MA, Niessen WJ (2007) Vessel axis tracking using topology constrained surface evolution. IEEE Trans Med Imaging 26(3):309–316. doi:10.1109/TMI.2006.891503

    Article  PubMed  Google Scholar 

  39. Milwer MB, Valencia LF, Hoyos MH, Magnin IE, Orkisz M (2007) Fast-marching contours for the segmentation of vessel lumen in CTA cross-sections. Conf Proc IEEE Eng Med Biol Soc 2007:791–794. doi:10.1109/IEMBS.2007.4352409

    PubMed  Google Scholar 

  40. Cuisenaire O, Virmani S, Olszewski M, Ardon R (2008) Fully automated segmentation of carotid and vertebral arteries from contrast enhanced CTA. In: Reinhardt (ed) Med imaging 2008: image processing, SPIE. pp R–R-8. doi:10.1117/12.770481

  41. Hameeteman K, Zuluaga MA, Freiman M, Joskowicz L, Cuisenaire O, Valencia LF, Gulsun MA, Krissian K, Mille J, Wong WC, Orkisz M, Tek H, Hoyos MH, Benmansour F, Chung AC, Rozie S, van Gils M, van den Borne L, Sosna J, Berman P, Cohen N, Douek PC, Sanchez I, Aissat M, Schaap M, Metz CT, Krestin GP, van der Lugt A, Niessen WJ, van Walsum T (2011) Evaluation framework for carotid bifurcation lumen segmentation and stenosis grading. Med Image Anal 15(4):477–488. doi:10.1016/j.media.2011.02.004, S1361-8415(11)00026-0 [pii]

    Article  PubMed  CAS  Google Scholar 

  42. Scherl H, Hornegger J, Prummer M, Lell M (2007) Semi-automatic level-set based segmentation and stenosis quantification of the internal carotid artery in 3D CTA data sets. Med Image Anal 11(1):21–34. doi:10.1016/j.media.2006.09.004, S1361-8415(06)00076-4 [pii]

    Article  PubMed  Google Scholar 

  43. Wintermark M, Glastonbury C, Tong E, Lau BC, Schaeffer S, Chien JD, Haar PJ, Saloner D (2008) Semi-automated computer assessment of the degree of carotid artery stenosis compares favorably to visual evaluation. J Neurol Sci 269(1–2):74–79. doi:10.1016/j.jns.2007.12.023, S0022-510X(07)00816-7 [pii]

    Article  PubMed  Google Scholar 

  44. Berg M, Zhang Z, Ikonen A, Manninen H, Vanninen R (2005) Carotid stenosis assessment with CT angiography using advanced vessel analysis software. Int Congr Ser 1281:322–327

    Article  Google Scholar 

  45. Zhang Z, Berg M, Ikonen A, Kononen M, Kalviainen R, Manninen H, Vanninen R (2005) Carotid stenosis degree in CT angiography: assessment based on luminal area versus luminal diameter measurements. Eur Radiol 15(11):2359–2365. doi:10.1007/s00330-005-2801-2

    Article  PubMed  Google Scholar 

  46. Groen HC, Gijsen FJ, van der Lugt A, Ferguson MS, Hatsukami TS, van der Steen AF, Yuan C, Wentzel JJ (2007) Plaque rupture in the carotid artery is localized at the high shear stress region: a case report. Stroke 38(8):2379–2381. doi:10.1161/STROKEAHA.107.484766, STROKEAHA.107.484766 [pii]

    Article  PubMed  Google Scholar 

  47. Lee SW, Antiga L, Spence JD, Steinman DA (2008) Geometry of the carotid bifurcation predicts its exposure to disturbed flow. Stroke 39(8):2341–2347. doi:10.1161/STROKEAHA.107.510644, STROKEAHA.107.510644 [pii]

    Article  PubMed  Google Scholar 

  48. Cademartiri F, Mollet NR, Runza G, Bruining N, Hamers R, Somers P, Knaapen M, Verheye S, Midiri M, Krestin GP, de Feyter PJ (2005) Influence of intracoronary attenuation on coronary plaque measurements using multislice computed tomography: observations in an ex vivo model of coronary computed tomography angiography. Eur Radiol 15(7):1426–1431. doi:10.1007/s00330-005-2697-x

    Article  PubMed  Google Scholar 

  49. Romero JM, Babiarz LS, Forero NP, Murphy EK, Schaefer PW, Gonzalez RG, Lev MH (2009) Arterial wall enhancement overlying carotid plaque on CT angiography correlates with symptoms in patients with high grade stenosis. Stroke 40(5):1894–1896. doi:10.1161/STROKEAHA.108.529008, STROKEAHA.108.529008 [pii]

    Article  PubMed  Google Scholar 

  50. Saba L, Mallarini G (2011) Carotid plaque enhancement and symptom correlations: an evaluation by using multidetector row CT angiography. AJNR Am J Neuroradiol 32(10):1919–1925. doi:10.3174/ajnr.A2605, ajnr.A2605 [pii]

    Article  PubMed  CAS  Google Scholar 

  51. Streifler JY, Eliasziw M, Fox AJ, Benavente OR, Hachinski VC, Ferguson GG, Barnett HJ (1994) Angiographic detection of carotid plaque ulceration. Comparison with surgical observations in a multicenter study. North American Symptomatic Carotid Endarterectomy Trial. Stroke 25(6):1130–1132

    Article  PubMed  CAS  Google Scholar 

  52. Randoux B, Marro B, Koskas F, Duyme M, Sahel M, Zouaoui A, Marsault C (2001) Carotid artery stenosis: prospective comparison of CT, three-dimensional gadolinium-enhanced MR, and conventional angiography. Radiology 220(1):179–185

    PubMed  CAS  Google Scholar 

  53. Walker LJ, Ismail A, McMeekin W, Lambert D, Mendelow AD, Birchall D (2002) Computed tomography angiography for the evaluation of carotid atherosclerotic plaque: correlation with histopathology of endarterectomy specimens. Stroke 33(4):977–981

    Article  PubMed  Google Scholar 

  54. Saba L, Caddeo G, Sanfilippo R, Montisci R, Mallarini G (2007) Efficacy and sensitivity of axial scans and different reconstruction methods in the study of the ulcerated carotid plaque using multidetector-row CT angiography: comparison with surgical results. AJNR Am J Neuroradiol 28(4):716–723, doi:28/4/716 [pii]

    PubMed  CAS  Google Scholar 

  55. de Weert TT, Cretier S, Groen HC, Homburg P, Cakir H, Wentzel JJ, Dippel DW, van der Lugt A (2009) Atherosclerotic plaque surface morphology in the carotid bifurcation assessed with multidetector computed tomography angiography. Stroke 40(4):1334–1340. doi:10.1161/STROKEAHA.108.538439, STROKEAHA.108.538439 [pii]

    Article  PubMed  Google Scholar 

  56. Wintermark M, Jawadi SS, Rapp JH, Tihan T, Tong E, Glidden DV, Abedin S, Schaeffer S, Acevedo-Bolton G, Boudignon B, Orwoll B, Pan X, Saloner D (2008) High-resolution CT imaging of carotid artery atherosclerotic plaques. AJNR Am J Neuroradiol 29(5):875–882. doi:10.3174/ajnr.A0950, ajnr.A0950 [pii]

    Article  PubMed  CAS  Google Scholar 

  57. Estes JM, Quist WC, Lo Gerfo FW, Costello P (1998) Noninvasive characterization of plaque morphology using helical computed tomography. J Cardiovasc Surg (Torino) 39(5):527–534

    CAS  Google Scholar 

  58. Oliver TB, Lammie GA, Wright AR, Wardlaw J, Patel SG, Peek R, Ruckley CV, Collie DA (1999) Atherosclerotic plaque at the carotid bifurcation: CT angiographic appearance with histopathologic correlation. AJNR Am J Neuroradiol 20(5):897–901

    PubMed  CAS  Google Scholar 

  59. de Weert TT, Ouhlous M, Meijering E, Zondervan PE, Hendriks JM, van Sambeek MR, Dippel DW, van der Lugt A (2006) In vivo characterization and quantification of atherosclerotic carotid plaque components with multidetector computed tomography and histopathological correlation. Arterioscler Thromb Vasc Biol 26(10):2366–2372. doi:10.1161/01.ATV.0000240518.90124.57, 01.ATV.0000240518.90124.57 [pii]

    Article  PubMed  Google Scholar 

  60. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano R (1990) Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 15(4):827–832, doi:0735-1097(90)90282-T [pii]

    Article  PubMed  CAS  Google Scholar 

  61. Kwee RM (2010) Systematic review on the association between calcification in carotid plaques and clinical ischemic symptoms. J Vasc Surg 51(4):1015–1025. doi:10.1016/j.jvs.2009.08.072, S0741-5214(09)01788-1 [pii]

    Article  PubMed  Google Scholar 

  62. de Weert TT, de Monye C, Meijering E, Booij R, Niessen WJ, Dippel DW, van der Lugt A (2008) Assessment of atherosclerotic carotid plaque volume with multidetector computed tomography angiography. Int J Cardiovasc Imaging 24(7):751–759. doi:10.1007/s10554-008-9309-1

    Article  PubMed  Google Scholar 

  63. Vukadinovic D, van Walsum T, Manniesing R, Rozie S, Hameeteman R, de Weert TT, van der Lugt A, Niessen WJ (2010) Segmentation of the outer vessel wall of the common carotid artery in CTA. IEEE Trans Med Imaging 29(1):65–76. doi:10.1109/TMI.2009.2025702

    Article  PubMed  Google Scholar 

  64. Vukadinovic D, Rozie S, van Gils M, van Walsum T, Manniesing R, van der Lugt A, Niessen WJ (2011) Automated versus manual segmentation of atherosclerotic carotid plaque volume and components in CTA: associations with cardiovascular risk factors. Int J Cardiovasc Imaging 28(4):877–887. doi:10.1007/s10554-011-9890-6

    Article  PubMed  Google Scholar 

  65. Rozie S, de Weert TT, de Monye C, Homburg PJ, Tanghe HL, Dippel DW, van der Lugt A (2009) Atherosclerotic plaque volume and composition in symptomatic carotid arteries assessed with multidetector CT angiography; relationship with severity of stenosis and cardiovascular risk factors. Eur Radiol 19(9):2294–2301. doi:10.1007/s00330-009-1394-6

    Article  PubMed  CAS  Google Scholar 

  66. Homburg PJ, Rozie S, van Gils MJ, van den Bouwhuijsen QJ, Niessen WJ, Dippel DW, van der Lugt A (2011) Association between carotid artery plaque ulceration and plaque composition evaluated with multidetector CT angiography. Stroke 42(2):367–372. doi:10.1161/STROKEAHA.110.597369, STROKEAHA.110.597369 [pii]

    Article  PubMed  Google Scholar 

  67. Wintermark M, Arora S, Tong E, Vittinghoff E, Lau BC, Chien JD, Dillon WP, Saloner D (2008) Carotid plaque computed tomography imaging in stroke and nonstroke patients. Ann Neurol 64(2):149–157. doi:10.1002/ana.21424

    Article  PubMed  Google Scholar 

  68. Nandalur KR, Hardie AD, Raghavan P, Schipper MJ, Baskurt E, Kramer CM (2007) Composition of the stable carotid plaque: insights from a multidetector computed tomography study of plaque volume. Stroke 38(3):935–940. doi:10.1161/01.STR.0000257995.74834.92, 01.STR.0000257995. 74834.92 [pii]

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Erasmus MC, University Medical Center Rotterdam, ‘sGravendijkwal 230, 3015 CE, Rotterdam, The Netherlands

    Max J. van Gils, M. van Straten & Aad van der Lugt

  2. Biomedical Imaging Group Rotterdam, Department of Radiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

    K. Hameeteman & W. J. Niessen

  3. Biomedical Imaging Group Rotterdam, Department of Medical Informatics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

    K. Hameeteman & W. J. Niessen

  4. Imaging Science and Technology, Delft University of Technology, Delft, The Netherlands

    W. J. Niessen

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  1. Max J. van Gils
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  2. K. Hameeteman
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  3. M. van Straten
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  4. W. J. Niessen
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  5. Aad van der Lugt
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Correspondence to Max J. van Gils .

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Editors and Affiliations

  1. Department of Radiology, A.O.U Cagliari - Polo di Monserrato, Bivio per Sestu, Italy

    Luca Saba

  2. Instituto Superior Técnico Institute for Systems and Robotics, Lisboa, Portugal

    João Miguel Sanches

  3. Hospital de Santa Maria, Lisboa, Portugal

    Luís Mendes Pedro

  4. Stroke Research and Monitoring Division, AtheroPoint(TM) LLC, Roseville, California, USA

    Jasjit S. Suri

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van Gils, M.J., Hameeteman, K., van Straten, M., Niessen, W.J., van der Lugt, A. (2014). Quantitative CT Imaging of Carotid Arteries. In: Saba, L., Sanches, J., Pedro, L., Suri, J. (eds) Multi-Modality Atherosclerosis Imaging and Diagnosis. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7425-8_11

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  • DOI: https://doi.org/10.1007/978-1-4614-7425-8_11

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