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Biofilm-Related Periprosthetic Joint Infections

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Periprosthetic Joint Infection of the Hip and Knee

Abstract

The majority of animal studies that have been used to model biofilm-related infections that accompany the use of biomedical devices have primarily involved an initial inoculum of planktonic bacterial cells from batch cultures. Although valuable, data that has been derived from these experiments may not provide important clinical insight into how bacteria in well-established, mature biofilms impact device-related and other clinical infections when they initially contaminate a patient site or implanted device. In this chapter, a discussion is presented on the impact that a shift in biofilm research may have if initial inocula of well-established, mature biofilms are used to model device-related infections in animal models.

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Authors and Affiliations

  1. Department of Orthopaedics, University of Utah School of Medicine, 500 Foothill Drive (151F), Salt Lake City, UT, 84148, USA

    Dustin L. Williams Ph.D.

  2. Department of Orthopedics, George E. Wahlen Department of Veterans Affairs Medical Center, University of Utah School of Medicine, 500 Foothill Drive (151F), Salt Lake City, UT, 84148, USA

    Roy D. Bloebaum Ph.D.

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  1. Dustin L. Williams Ph.D.
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Correspondence to Roy D. Bloebaum Ph.D. .

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Editors and Affiliations

  1. OrthoCarolina Hip and Knee Center, Charlotte, North Carolina, USA

    Bryan D. Springer

  2. Rothman Institute of Orthopedics, Philadelphia, Pennsylvania, USA

    Javad Parvizi

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Williams, D.L., Bloebaum, R.D. (2014). Biofilm-Related Periprosthetic Joint Infections. In: Springer, B., Parvizi, J. (eds) Periprosthetic Joint Infection of the Hip and Knee. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7928-4_7

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