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Molecular Basis of Cell Death Programs in Mature T Cell Homeostasis

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References

  1. Lockshin RA, Zakeri Z. Programmed cell death and apoptosis: origins of the theory. Nat Rev Mol Cell Biol. 2001;2:545–50.

    PubMed  CAS  Google Scholar 

  2. Check E. Worm cast in starring role for Nobel prize. Nature. 2002;419:548–9.

    PubMed  CAS  Google Scholar 

  3. Marx J. Nobel prize in physiology or medicine. Tiny worm takes a star turn. Science. 2002;298(526).

    Google Scholar 

  4. Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature. 1988;335:440–2.

    PubMed  CAS  Google Scholar 

  5. McDonnell TJ, et al. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell. 1989;57:79–88.

    PubMed  CAS  Google Scholar 

  6. Snow AL, Lenardo MJ. Programmed cell death. In: Paul WE, editor. Fundamental immunology. Philadelphia, PA: Lippincott Williams & Wilkins; 2012. pp 718–40.

    Google Scholar 

  7. Ellis HM, Horvitz HR. Genetic control of programmed cell death in the nematode C. elegans. Cell. 1986;44:817–29.

    PubMed  CAS  Google Scholar 

  8. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972;26:239–57.

    PubMed  CAS  Google Scholar 

  9. Cohen JJ, Duke RC, Fadok VA, Sellins KS. Apoptosis and programmed cell death in immunity. Annu Rev Immunol. 1992;10:267–93.

    PubMed  CAS  Google Scholar 

  10. Lenardo M, et al. Mature T lymphocyte apoptosis–immune regulation in a dynamic and unpredictable antigenic environment. Annu Rev Immunol. 1999;17:221–53.

    PubMed  CAS  Google Scholar 

  11. Yuan S, et al. Characterization of the extrinsic apoptotic pathway in the basal chordate amphioxus. Sci Signal. 2010;3:ra66.

    PubMed  Google Scholar 

  12. Bajoghli B, et al. Evolution of genetic networks underlying the emergence of thymopoiesis in vertebrates. Cell. 2009;138:186–97.

    PubMed  CAS  Google Scholar 

  13. Han J, Zhong CQ, Zhang DW. Programmed necrosis: backup to and competitor with apoptosis in the immune system. Nat Immunol. 2011;12:1143–9.

    PubMed  CAS  Google Scholar 

  14. Yu L, et al. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science. 2004;304:1500–2.

    PubMed  CAS  Google Scholar 

  15. Freundt EC, et al. The open reading frame 3a protein of severe acute respiratory syndrome-associated coronavirus promotes membrane rearrangement and cell death. J Virol. 2010;84:1097–109.

    PubMed  CAS  Google Scholar 

  16. Taylor RC, Cullen SP, Martin SJ. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol. 2008;9:231–41.

    PubMed  CAS  Google Scholar 

  17. Kersse K, Verspurten J, Vanden Berghe T, Vandenabeele P. The death-fold superfamily of homotypic interaction motifs. Trends Biochem Sci. 2011;36:541–52.

    PubMed  CAS  Google Scholar 

  18. Lavrik I, et al. The active caspase-8 heterotetramer is formed at the CD95 DISC. Cell Death Differ. 2003;10:144–5.

    PubMed  CAS  Google Scholar 

  19. Janssens S, Tinel A. The PIDDosome. DNA-damage-induced apoptosis and beyond. Cell Death Differ. 2012;19:13–20.

    PubMed  CAS  Google Scholar 

  20. Luthi AU, Martin SJ. The CASBAH: a searchable database of caspase substrates. Cell Death Differ. 2007;14:641–50.

    PubMed  CAS  Google Scholar 

  21. Deveraux QL, et al. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J. 1998;17:2215–23.

    PubMed  CAS  Google Scholar 

  22. Deveraux QL, Takahashi R, Salvesen GS, Reed JC. X-linked IAP is a direct inhibitor of cell-death proteases. Nature. 1997;388:300–4.

    PubMed  CAS  Google Scholar 

  23. Deveraux QL, et al. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J. 1999;18:5242–51.

    PubMed  CAS  Google Scholar 

  24. Kaufmann T, Strasser A, Jost PJ. Fas death receptor signalling: roles of Bid and XIAP. Cell Death Differ. 2012;19:42–50.

    PubMed  CAS  Google Scholar 

  25. Du C, Fang M, Li Y, Li L, Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 2000;102:33–42.

    PubMed  CAS  Google Scholar 

  26. Verhagen AM, et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell. 2000;102:43–53.

    PubMed  CAS  Google Scholar 

  27. Suzuki Y, et al. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell. 2001;8:613–21.

    PubMed  CAS  Google Scholar 

  28. Chun HJ, et al. Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature. 2002;419:395–9.

    PubMed  CAS  Google Scholar 

  29. Su H, et al. Requirement for caspase-8 in NF-kappaB activation by antigen receptor. Science. 2005;307:1465–8.

    PubMed  CAS  Google Scholar 

  30. Chan FK, et al. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science. 2000;288:2351–4.

    PubMed  CAS  Google Scholar 

  31. Schneider P, et al. Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity. J Exp Med. 1998;187:1205–13.

    PubMed  CAS  Google Scholar 

  32. Guicciardi ME, Gores GJ. Life and death by death receptors. FASEB J. 2009;23:1625–37.

    PubMed  CAS  Google Scholar 

  33. Migone TS, et al. TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity. 2002;16:479–92.

    PubMed  CAS  Google Scholar 

  34. Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature. 2009;457:981–9.

    PubMed  CAS  Google Scholar 

  35. Chinnaiyan AM, et al. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science. 1996;274:990–2.

    PubMed  CAS  Google Scholar 

  36. Liu J, et al. Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice. Immunity. 2001;15:23–34.

    PubMed  CAS  Google Scholar 

  37. Zhao H, et al. Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice. J Exp Med. 2001;194:1441–8.

    PubMed  CAS  Google Scholar 

  38. Siegel RM, et al. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science. 2000;288:2354–7.

    PubMed  CAS  Google Scholar 

  39. Siegel RM, et al. SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane. J Cell Biol. 2004;167:735–44.

    PubMed  CAS  Google Scholar 

  40. Wang L, et al. The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat Struct Mol Biol. 2010;17:1324–9.

    PubMed  CAS  Google Scholar 

  41. Krammer PH, Arnold R, Lavrik IN. Life and death in peripheral T cells. Nat Rev Immunol. 2007;7:532–42.

    PubMed  CAS  Google Scholar 

  42. Kaufmann T, et al. The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest. Cell. 2007;129:423–33.

    PubMed  CAS  Google Scholar 

  43. McKenzie MD, et al. Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells. Diabetes. 2008;57:1284–92.

    PubMed  CAS  Google Scholar 

  44. Yin XM, et al. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature. 1999;400:886–91.

    PubMed  CAS  Google Scholar 

  45. Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 1998;94:491–501.

    PubMed  CAS  Google Scholar 

  46. Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell. 1998;94:481–90.

    PubMed  CAS  Google Scholar 

  47. Jost PJ, et al. XIAP discriminates between type I and type II FAS-induced apoptosis. Nature. 2009;460:1035–9.

    PubMed  CAS  Google Scholar 

  48. Algeciras-Schimnich A, Griffith TS, Lynch DH, Paya CV. Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis. J Immunol. 1999;162:5205–11.

    PubMed  CAS  Google Scholar 

  49. Bentele M, et al. Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis. J Cell Biol. 2004;166:839–51.

    PubMed  CAS  Google Scholar 

  50. Refaeli Y, Van Parijs L, London CA, Tschopp J, Abbas AK. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity. 1998;8:615–23.

    PubMed  CAS  Google Scholar 

  51. Schmitz I, et al. Resistance of short term activated T cells to CD95-mediated apoptosis correlates with de novo protein synthesis of c-FLIPshort. J Immunol. 2004;172:2194–200.

    PubMed  CAS  Google Scholar 

  52. Irmler M, et al. Inhibition of death receptor signals by cellular FLIP. Nature. 1997;388:190–5.

    PubMed  CAS  Google Scholar 

  53. Ozturk S, Schleich K, Lavrik IN. Cellular FLICE-like inhibitory proteins (c-FLIPs): fine-tuners of life and death decisions. Exp Cell Res. 2012;318:1324–31.

    PubMed  CAS  Google Scholar 

  54. Sun H, et al. TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis. Cell. 2008;133:415–26.

    PubMed  CAS  Google Scholar 

  55. Condorelli G, et al. PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis. Oncogene. 1999;18:4409–15.

    PubMed  CAS  Google Scholar 

  56. Zheng L, et al. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature. 1995;377:348–51.

    PubMed  CAS  Google Scholar 

  57. Hsu H, Shu HB, Pan MG, Goeddel DV. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell. 1996;84:299–308.

    PubMed  CAS  Google Scholar 

  58. Micheau O, Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell. 2003;114:181–90.

    PubMed  CAS  Google Scholar 

  59. Schneider-Brachert W, et al. Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles. Immunity. 2004;21:415–28.

    PubMed  CAS  Google Scholar 

  60. Cho YS, et al. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell. 2009;137:1112–23.

    PubMed  CAS  Google Scholar 

  61. He S, et al. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell. 2009;137:1100–11.

    PubMed  CAS  Google Scholar 

  62. Zhang D, Lin J, Han J. Receptor-interacting protein (RIP) kinase family. Cell Mol Immunol. 2010;7:243–9.

    PubMed  CAS  Google Scholar 

  63. Jiang Y, Woronicz JD, Liu W, Goeddel DV. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. Science. 1999;283:543–6.

    PubMed  CAS  Google Scholar 

  64. Peschon JJ, et al. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol. 1998;160:943–52.

    PubMed  CAS  Google Scholar 

  65. Wajant H, Pfizenmaier K, Scheurich P. Tumor necrosis factor signaling. Cell Death Differ. 2003;10:45–65.

    PubMed  CAS  Google Scholar 

  66. Pan G, et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science. 1997;277:815–8.

    PubMed  CAS  Google Scholar 

  67. Clancy L, et al. Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. Proc Natl Acad Sci U S A. 2005;102:18099–104.

    PubMed  CAS  Google Scholar 

  68. Gonzalvez F, Ashkenazi A. New insights into apoptosis signaling by Apo2L/TRAIL. Oncogene. 2010;29:4752–65.

    PubMed  CAS  Google Scholar 

  69. Wagner KW, et al. Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL. Nat Med. 2007;13:1070–7.

    PubMed  CAS  Google Scholar 

  70. Jin Z, et al. Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell. 2009;137:721–35.

    PubMed  CAS  Google Scholar 

  71. Finnberg N, Klein-Szanto AJ, El-Deiry WS. TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis. J Clin Invest. 2008;118:111–23.

    PubMed  CAS  Google Scholar 

  72. Janssen EM, et al. CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature. 2005;434:88–93.

    PubMed  CAS  Google Scholar 

  73. Lenardo MJ. Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Nature. 1991;353:858–61.

    PubMed  CAS  Google Scholar 

  74. Hornung F, Zheng L, Lenardo MJ. Maintenance of clonotype specificity in CD95/Apo-1/Fas-mediated apoptosis of mature T lymphocytes. J Immunol. 1997;159:3816–22.

    PubMed  CAS  Google Scholar 

  75. Takahashi T, et al. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell. 1994;76:969–76.

    PubMed  CAS  Google Scholar 

  76. Snow AL, et al. Critical role for BIM in T cell receptor restimulation-induced death. Biol Direct. 2008;3:34.

    PubMed  Google Scholar 

  77. Watanabe-Fukunaga R, Brannan CI, Copeland NG, Jenkins NA, Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature. 1992;356:314–7.

    PubMed  CAS  Google Scholar 

  78. Wong B, Arron J, Choi Y. T cell receptor signals enhance susceptibility to Fas-mediated apoptosis. J Exp Med. 1997;186:1939–44.

    PubMed  CAS  Google Scholar 

  79. Boehme SA, Lenardo MJ. Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle. Eur J Immunol. 1993;23:1552–60.

    PubMed  CAS  Google Scholar 

  80. Garcia-Saez AJ. The secrets of the Bcl-2 family. Cell Death Differ. 2012;19:1733–40.

    PubMed  CAS  Google Scholar 

  81. Martinou JC, Youle RJ. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell. 2011;21:92–101.

    PubMed  CAS  Google Scholar 

  82. Boehning D, et al. Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nat Cell Biol. 2003;5:1051–61.

    PubMed  CAS  Google Scholar 

  83. Rong YP, et al. The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor. Proc Natl Acad Sci U S A. 2009;106:14397–402.

    PubMed  CAS  Google Scholar 

  84. Wu G, et al. Structural basis of IAP recognition by Smac/DIABLO. Nature. 2000;408:1008–12.

    PubMed  CAS  Google Scholar 

  85. Yang QH, Church-Hajduk R, Ren J, Newton ML, Du C. Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis. Genes Dev. 2003;17:1487–96.

    PubMed  CAS  Google Scholar 

  86. Polster BM, Basanez G, Etxebarria A, Hardwick JM, Nicholls DG. Calpain I induces cleavage and release of apoptosis-inducing factor from isolated mitochondria. J Biol Chem. 2005;280:6447–54.

    PubMed  CAS  Google Scholar 

  87. Marchetti P, et al. The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus. Cancer Res. 1999;59:6257–66.

    PubMed  CAS  Google Scholar 

  88. Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell. 1997;90:405–13.

    PubMed  CAS  Google Scholar 

  89. Yu X, et al. A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform. Structure. 2005;13:1725–35.

    PubMed  CAS  Google Scholar 

  90. Acehan D, et al. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol Cell. 2002;9:423–32.

    PubMed  CAS  Google Scholar 

  91. Reubold TF, Wohlgemuth S, Eschenburg S. Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis. Structure. 2011;19:1074–83.

    PubMed  CAS  Google Scholar 

  92. Reubold TF, Wohlgemuth S, Eschenburg S. A new model for the transition of APAF-1 from inactive monomer to caspase-activating apoptosome. J Biol Chem. 2009;284:32717–24.

    PubMed  CAS  Google Scholar 

  93. Pop C, Timmer J, Sperandio S, Salvesen GS. The apoptosome activates caspase-9 by dimerization. Mol Cell. 2006;22:269–75.

    PubMed  CAS  Google Scholar 

  94. Razvi ES, Jiang Z, Woda BA, Welsh RM. Lymphocyte apoptosis during the silencing of the immune response to acute viral infections in normal, lpr, and Bcl-2-transgenic mice. Am J Pathol. 1995;147:79–91.

    PubMed  CAS  Google Scholar 

  95. Strasser A. The role of BH3-only proteins in the immune system. Nat Rev Immunol. 2005;5:189–200.

    PubMed  CAS  Google Scholar 

  96. Hildeman DA, et al. Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity. 2002;16:759–67.

    PubMed  CAS  Google Scholar 

  97. Pellegrini M, Belz G, Bouillet P, Strasser A. Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim. Proc Natl Acad Sci U S A. 2003;100:14175–80.

    PubMed  CAS  Google Scholar 

  98. Ley R, Balmanno K, Hadfield K, Weston C, Cook SJ. Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J Biol Chem. 2003;278:18811–6.

    PubMed  CAS  Google Scholar 

  99. Matsui H, Asou H, Inaba T. Cytokines direct the regulation of Bim mRNA stability by heat-shock cognate protein 70. Mol Cell. 2007;25:99–112.

    PubMed  CAS  Google Scholar 

  100. Bauer A, et al. The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells. Proc Natl Acad Sci U S A. 2006;103:10979–84.

    PubMed  CAS  Google Scholar 

  101. Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell. 2006;21:749–60.

    PubMed  CAS  Google Scholar 

  102. Oliveira JB, et al. NRAS mutation causes a human autoimmune lymphoproliferative syndrome. Proc Natl Acad Sci U S A. 2007;104:8953–8.

    PubMed  CAS  Google Scholar 

  103. Oliveira JB, et al. Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop. Blood. 2010;116:e35–40.

    PubMed  CAS  Google Scholar 

  104. Fisher GH, et al. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell. 1995;81:935–46.

    PubMed  CAS  Google Scholar 

  105. Jackson CE, et al. Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance. Am J Hum Genet. 1999;64:1002–14.

    PubMed  CAS  Google Scholar 

  106. Niemela JE, et al. Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis. Blood. 2011;117:2883–6.

    PubMed  Google Scholar 

  107. Takagi M, et al. Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation. Blood. 2011;117:2887–90.

    PubMed  CAS  Google Scholar 

  108. Shannon K, Li Q. Oncogenic Ras scales the ALPS. Blood. 2011;117:2747–8.

    PubMed  CAS  Google Scholar 

  109. Pachlopnik Schmid J, et al. Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP deficiency). Blood. 2011;117:1522–9.

    PubMed  Google Scholar 

  110. Proust R, Bertoglio J, Gesbert F. The Adaptor Protein SAP Directly Associates with CD3zeta Chain and Regulates T Cell Receptor Signaling. PLoS One. 2012;7:e43200.

    PubMed  CAS  Google Scholar 

  111. Nichols KE, Ma CS, Cannons JL, Schwartzberg PL, Tangye SG. Molecular and cellular pathogenesis of X-linked lymphoproliferative disease. Immunol Rev. 2005;203:180–99.

    PubMed  CAS  Google Scholar 

  112. Snow AL, et al. Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency. J Clin Invest. 2009;119:2976–89.

    PubMed  CAS  Google Scholar 

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  1. Laboratory of Immunology, NIAID, NIH, 10 Center Drive, Building 10, Room 11N311, Bethesda, MD, 20892-1892, USA

    Carrie L. Lucas Ph.D. & Michael J. Lenardo M.D.

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  1. Carrie L. Lucas Ph.D.
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  2. Michael J. Lenardo M.D.
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Correspondence to Michael J. Lenardo M.D. .

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  1. Dept. of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA

    Hao Wu

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Lucas, C.L., Lenardo, M.J. (2014). Molecular Basis of Cell Death Programs in Mature T Cell Homeostasis. In: Wu, H. (eds) Cell Death. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9302-0_3

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