Abstract
A prolonged prothrombin time usually involves a problem with factor VII, either under synthesis or with the gamma-carboxylation of an inactive form of factor VII. This latter problem is mostly due to a problem with vitamin K, either antagonism to it, such as warfarin use, or low levels of it, such as interference with normal gut flora. This chapter will discuss congenital deficiency states of factor VII, as well as the rare inhibitor to factor VII activity. Much of the chapter will discuss how vitamin K works and the various ways vitamin K deficiency can lead to a bleeding diathesis.
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Lichtin, A. (2014). Prolonged PT. In: Lichtin, A., Bartholomew, J. (eds) The Coagulation Consult. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9560-4_3
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