Abstract
Prostaglandins (PGs) act as local hormones to regulate both physiological and pathological responses and have been implicated as causative factors in the pathogenesis of many diseases, including inflammation, asthma, atherosclerosis and cancer. Additionally, PGs can also act as autocrine modulators of cell proliferation in several cell lines including the human lung adenocarcinoma A549 cell line (Croxtall & Flower, 1992). PGE2 production is regulated both by the release of AA from cellular phospholipids by PLA2 enzymes and by the conversion of AA to PGH2 by the enzyme cyclo-oxygenase (COX).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Balsinde, J. & Dennis, E.A. (1997). Function and Inhibition of Intracellular Calcium-independent Phospholipase A2. J. Biol. Chem. 272, 16069–16072.
Croxtall, J.D. & Flower, R.J. (1992). Lipocortin 1 mediates dexamethasone-induced growth arrest of the A549 lung adenocarcinoma cell line. Proc. Natl. Acad. Sci. USA 89, 3571–3575.
Lin, L-L., Lin, A.Y. &Knopf, J.L. (1992). Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid. Proc. Natl. Acad. Sci. USA 89, 6147–6151.
Wissing, D., Mouritzen, H., Egeblad,M., Poirier, G.G. & Jaattela, M. (1997). Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor induced apoptosis. Proc. Natl. Acad. Sci. USA 94,5073–5077.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media New York
About this chapter
Cite this chapter
Choudhury, Q.G., Mckay, D.T., Flower, R.J., Croxtall, J.D. (2002). Investigation Into the Involvement of Phospholipases A2 and Map Kinases in Modulation of Aa Release and Cell Growth in A549 Cells. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E., Serhan, C. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. Advances in Experimental Medicine and Biology, vol 507. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0193-0_6
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0193-0_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4960-0
Online ISBN: 978-1-4615-0193-0
eBook Packages: Springer Book Archive