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H+K+-ATPase, the Dominant Gastric Autoantigen in Helicobacter pylori Infection

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Mechanisms and Consequences of Proton Transport

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Abstract

The pathogen Helicobacter pylori colonizes the gastric mucosa of half of mankind and causes a variety of diseases. While in the early days of H. pylori research most attention was given to its ability to cause peptic ulcers, much of the current focus is on its causative role in gastric cancer. Gastric cancer ranks second in malignancy-associated mortality, and in certain regions in The People’s Republic of China this mortality amounts to 70/100.000/year.

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Author information

Authors and Affiliations

  1. Dept. Med. Microbiology, Vrije Universiteit Med. Center, Amsterdam, The Netherlands

    B. J. Appelmelk, M. P. Bergman, A. V. D. Aar, W. Lakhai & C. M. J. E. Vandenbroucke-Grauls

  2. Depts. Int. Med. and Surgery, Univ. Florence, Italy

    M. M. D’Elios, A. Azzurri, A. Amedei, M. Benagiano, F. Cianchi, S. Romagnani & G. F. Del Prete

  3. Dept. Mol. and Cell. Biol, Univ. California, Berkeley, USA

    J. G. Forte

  4. Dept. Biochem., Univ. Nijmegen, The Netherlands

    J. J. de Pont

Authors
  1. B. J. Appelmelk
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  2. M. P. Bergman
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  3. A. V. D. Aar
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  4. W. Lakhai
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  5. M. M. D’Elios
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  6. A. Azzurri
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  7. A. Amedei
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  8. M. Benagiano
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  9. F. Cianchi
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  10. S. Romagnani
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  11. J. G. Forte
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  12. G. F. Del Prete
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  13. J. J. de Pont
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  14. C. M. J. E. Vandenbroucke-Grauls
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Editor information

Editors and Affiliations

  1. Graduate School of Pharmaceutical Science, The University of Tokyo, Japan

    Tetsuro Urushidani

  2. Dept. of Molecular & Cell Biology, University of California at Berkeley, USA

    John G. Forte

  3. Center for Ulcer Research & Education, University of California, Los Angeles, USA

    George Sachs

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© 2002 Springer Science+Business Media New York

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Appelmelk, B.J. et al. (2002). H+K+-ATPase, the Dominant Gastric Autoantigen in Helicobacter pylori Infection. In: Urushidani, T., Forte, J.G., Sachs, G. (eds) Mechanisms and Consequences of Proton Transport. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0971-4_10

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  • DOI: https://doi.org/10.1007/978-1-4615-0971-4_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5330-0

  • Online ISBN: 978-1-4615-0971-4

  • eBook Packages: Springer Book Archive

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