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Laboratory Diagnosis of Fungal Infection in the Intensive Care Unit

North American Perspective

  • Chapter
Fungal Infection in the Intensive Care Unit

Part of the book series: Perspectives on Critical Care Infectious Diseases ((CCID,volume 6))

Abstract

Sophisticated technologies to prolong the lives of severely debilitated patients have become more commonplace. Ironically, as a result of these medical advances, a population of patients more vulnerable to fungal infections has been produced. Individuals who would previously have died from major illnesses now survive in a debilitated state, often requiring intensive care for prolonged periods of time. As a consequence, the incidence of invasive fungal infections among critically-ill patients has increased significantly over the past decade. Most fungal infections in the intensive care unit (ICU) are caused by opportunistic pathogens, principallyCandidaspecies, which are commonly found as normal commensals of the human gastrointestinal tract, skin, and/or mucosa. Less commonly, infections in critically-ill patients are caused by moulds, such asAspergillusspecies, which are ubiquitous in the environment. These fungi do not ordinarily cause invasive infection unless the host is immunocompromised or otherwise debilitated; therefore, the inherently weakened condition of most critically-ill patients, along with the multiplicity of invasive procedures and immunosuppressive drugs used to treat underlying illnesses in this patient population, make them particularly susceptible to invasive fungal diseases.

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  1. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

    Christine J. Morrison

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  1. University of Wales College of Medicine, Cardiff, UK

    R. A. Barnes

  2. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

    D. W. Warnock

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Morrison, C.J. (2002). Laboratory Diagnosis of Fungal Infection in the Intensive Care Unit. In: Barnes, R.A., Warnock, D.W. (eds) Fungal Infection in the Intensive Care Unit. Perspectives on Critical Care Infectious Diseases, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0977-6_5

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