Abstract
Methamphetamine (MTH) has been found to induce long-lasting changes in the nigrostriatal dopamine (DA) system. The MTH-induced neurotoxicity is characterized by decreases in the number of DA transporters (DAT), in DA concentration and tyrosine hydroxylase activity (Ricuarte et al., 1982; Schmidt et al., 1985). A massive release of DA after repeated doses of MTH yields a highly reactive oxygen species and rapid reduction in DAT activity (Fleckenstein et al., 1997).
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Abstract
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Golembiowska, K. (2000). Neuroprotective Role of Endogenous Adenosine in Methamphetamine-Induced Toxicity in Rat Striatum. In: Storch, A., Collins, M.A. (eds) Neurotoxic Factors in Parkinson’s Disease and Related Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1269-1_34
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DOI: https://doi.org/10.1007/978-1-4615-1269-1_34
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