Abstract
A family of hemolymph peptides with diverse biological activities has been identified in several Lepidopteran species. These peptides can cause rapid paralysis (Skinner et al., 1991), block growth and development (Hayakawa, 1991), and stimulate plasmatocyte spreading and aggregation (Clark et al., 1997). The 23-residue peptides are produced from larger inactive precursors in plasma. The precursor proteins are rapidly converted by a specific proteolysis to active molecules upon bleeding and perhaps after parasitization or infection.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Clark, K.D., Pech, L.L., and Strand, M.R. (1997) Isolation and identification of a plasmatocyte-spreading peptide from the hemolymph of the lepidopteran insect Pseudoplusia includens. J. Biol. Chem. 272, 23440–23447.
Clark, K.D., Witherell, A., and Strand, M.R. (1998) Plasmatocyte spreading peptide is encoded by an mRNA differentially expressed in tissues of the moth Pseudoplusia includens. Bioch. Biochem. Res. Commun. 250,479–485.
Hayakawa, Y. (1991) Structure of a growth-blocking peptide present in parasitized insect hemolymph. J.Biol.Chem. 266, 7982–7982.
Hayakawa, Y. and Ohnishi, A. (1998) Cell growth activity of growth-blocking peptide. Biochem. Biophys. Res. Commun. 250, 194–199.
Hayakawa, Y., Ohnishi, A., Yamanaka, A., Izumi, S., and Tomino, S. (1995) Molecular cloning and characterization of cDNA for insect biogenic peptide, growth blocking peptide. FEBS Lett. 376, 185–189.
Skinner, W.S., Dennis, RA, Li, J.P., Summerfelt, R.M., Carney, R.L., and Quistad, G.B. (1991) Isolation and identification of paralytic peptides from hemolymph of the lepidopteran insects Manduca sexta, Spodoptera exigua, and Heliothis virescens. J. Biol. Chem. 266, 12873–12877.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2001 Springer Science+Business Media New York
About this chapter
Cite this chapter
Wang, Y., Jiang, H., Kanost, M.R. (2001). Paralytic and Plasmatocyte Spreading Peptide From Manduca sexta . In: Beck, G., Sugumaran, M., Cooper, E.L. (eds) Phylogenetic Perspectives on the Vertebrate Immune System. Advances in Experimental Medicine and Biology, vol 484. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1291-2_36
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1291-2_36
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5481-9
Online ISBN: 978-1-4615-1291-2
eBook Packages: Springer Book Archive