Abstract
The cardiovascular response to dynamic exercise is characterized by increases in blood pressure, myocardial contractility, and heart rate (Mitchell, 1990). In addition, cardiac output is redistributed such that blood flow is reduced in the renal and splanchnic circulations,while it is greatly increased to the heart and contracting skeletal muscles (Armstrong et al, 1987). Although central neural mechanisms (i.e. central command) and reflexes originating in working skeletal muscles are largely responsible for these alterations (Mitchell, 1990), hormones released during physical activity also may contribute to or modulate the cardiovascular response to dynamic exercise.
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References
Mitchell, J.H. 1990, Neural control of the circulation during exercise. Med. Sci. Sports Exercise. 22:141–154.
Armstrong, R.B., Delp, M.D., Goljan E.F., and Laughlin, M.H. 1987, Distribution of blood flow in muscles of miniature swine during exercise. J. Appl. Physiol. 62:1285–1298.
Stebbins, C.L., Symons, J.D., McKirnan, M.D., and Hwang, F.W. 1994, Factors associated with vasopressin release in exercising swine. Am. J. Physiol. 266 (35):R118–R124.
Cowley, A.W. Jr. and Liard J.F. 1987, Cardiovascular actions of vasopressin. In D.M. Gash and G.J. Boer (eds) Vasopressin: Principles and Properties, Plenum Press, New York, NY, 389–433.
Liard, J.F., Deriaz, O., Schelling P., and Thibonnier P. 1982, Cardiac output distribution during vasopressin infusion or dehydration in conscious dogs. Am. J. Physiol. 243 (12):H663–H669.
Symons, J.D., Longhurst, J.C., and Stebbins C.L. 1993, Response of collateral-dependent myocardium to vasopressin release during exercise. Am. J. Physiol. 264:H1644–H1652.
Stebbins, C.L. and Symons, J.D. 1993, Vasopressin contributes to the cardiovascular response to dynamic exercise. Am. J. Physiol. 264 (33):H1701–H1707.
Stebbins, C.L. and Symons, J.D. 1995, Role of angiotensin II in the hemodynamic response to dynamic exercise in the miniswine. J. Appl. Physiol. 78 (1):185–190.
Herblin, W.F., Chiu, A.T., McCall, D.E., Ardecky, R. J., Carini, D.J. 1991, Angiotensin II receptor heterogeneity. Am. J. Hypertens. 4 (4):299S–302S.
Fagard, R., Amery, A., Reybrouck, T., Lijnen, P., Moerman, E., Bogaert, M., and De Schaepdryver, A. 1977, Effects of angiotensin antagonism on hemodynamics, renin, and catecholamines during exercise. J. Appl. Physiol. 43:440–444.
Fagard, R., Amery, A., Reybrouck, T., Lijnen, P., Billiet, L., Bogaert, M., Moerman, E., and de Schaepdryver A. 1978, Effects of angiotensin antagonism at rest and during exercise in sodium-deplete man. J. Appl. Physiol. 45 (3):403–407.
Fagard, R., Lijnen, P., Vanhees, L., Amery, A. 1982, Hemodynamic response to converting enzyme inhibition at rest and exercise in humans. J. Appl. Physiol. 53 (3):576–581.
Swartz, S.L. and Williams, G.H. 1982, Angiotensin-converting enzyme inhibition and prostaglandins. Am. J. Cardiol. 49:1405–1409.
Grafe, M., Bossaller, C., Graf, K., Auch-Wchwelk, W., Baukmgarten, C.R., Hildebrandt, A., and Fleck, E. 1993, Effect of angiotensin-converting enzyme inhibition on bradykinin metabolism by vascular endothelial cells. Am. J. Physiol. 33:H1493–H1497.
Wong, P.C., Price, W.A., Chiu, A.T., Duncia, J.V., Carini, D.J., Wexler, R.R., Johnson, A.L., and Timmermans, P.B. 1990, Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP 753, an orally active antihypertensive agent. J. Pharmacol. Exp. Ther. 252:719–725.
Smith, R.D., Chiu, A.T., Wong, P.C., Herblin, W.F., and Timmermans, P.B.M. W.M. 1992, Pharmacology of nonpeptide angiotensin II receptor antagonists. Annu. Rev. Pharmacol. Toxicol. 32: 135–165.
MacLean, M.R. and Ungar A. 1986, Effects of the renin-angiotensin system on the reflex response of the adrenal medulla to hypotension in the dog. J. Physiol. (London). 373:343–352.
Szabo, B.L., Hedler, L., Schurr, C., and Starke, K. 1990, Peripheral presynaptic facilitatory effect of angiotensin II on noradrenaline release in anesthetized rabbits. J. Cardiovasc. Pharmacol. 15:968– 975.
Mohrman, D.E. and Feigl, E.O. 1978, Competition between sympathetic vasoconstriction and metabolic vasodilation in the canine coronary circulation. Circ. Res. 42:79–86.
Feigl, E.O. The paradox of adrenergic coronary vasoconstriction. 1987, Circulation. 76:737–745.
Ball, R.M., Bache, R.J., Cobb, F.R., and Greenfield, J.C. Jr. 1975, Regional myocardial blood flow during graded treadmill exercise in the dog. J. Clin. Invest. 55:43–49.
Huang, A.H. and Feigl, E.O. 1988, Adrenergic coronary vasoconstriction helps maintain uniform transmural blood flow distribution during exercise. Circ. Res. 62:286–298.
Rowell, L.B. Human cardiovascular control. 1986, New York: Oxford Univ. Press.
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Symons, J.D., Stebbins, C.L. (1995). The Role of Vasopressin and Angiotensin II in the Hemodynamic Response to Dynamic Exercise. In: Kappagoda, C.T., Kaufman, M.P. (eds) Control of the Cardiovascular and Respiratory Systems in Health and Disease. Advances in Experimental Medicine and Biology, vol 381. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1895-2_20
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DOI: https://doi.org/10.1007/978-1-4615-1895-2_20
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