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In Situ Expression of Activation Markers by Langerhans’ Cells Containing GM-CSF

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Dendritic Cells in Fundamental and Clinical Immunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 378))

Abstract

Langerhans’ cells (LC) are dendritic, marrow-derived cells. When they are activated, they migrate from the epidermis to the paracortical zone of the draining lymph node, where they are called interdigitating dendritic cells (IDC). Langerhans’ cell histiocytosis (LCH) is characterized by the accumulation of large mononucleated cells, associated with inflammatory cells. The LCH cells contain Birbeck granules within their cytoplasm, and express CDla. This suggests that they belong to the LC lineage.

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Authors and Affiliations

  1. Service d’anatomie et de cytologie pathologiques and service de dermatologie, Hôpital Necker-Enfants Malades, 75743, Paris cedex 15, France

    J. F. Emile, S. Fraitag, M. Leborgne, Y. de Prost & N. Brousse

Authors
  1. J. F. Emile
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  2. S. Fraitag
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  3. M. Leborgne
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  4. Y. de Prost
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  5. N. Brousse
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Editor information

Editors and Affiliations

  1. Laboratory for Immunological Research, Schering-Plough, Dardilly, France

    Jacques Banchereau

  2. INSERM U346, Hôpital Edouard Herriot, Lyon, France

    Daniel Schmitt

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© 1995 Springer Science+Business Media New York

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Emile, J.F., Fraitag, S., Leborgne, M., de Prost, Y., Brousse, N. (1995). In Situ Expression of Activation Markers by Langerhans’ Cells Containing GM-CSF. In: Banchereau, J., Schmitt, D. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 378. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1971-3_21

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  • DOI: https://doi.org/10.1007/978-1-4615-1971-3_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5811-4

  • Online ISBN: 978-1-4615-1971-3

  • eBook Packages: Springer Book Archive

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