Abstract
Integrins are a family of cell surface molecules mediating diverse biological events involving cell-matrix as well as cell-cell interactions. The term integrin denotes a functional linkage between the extracellular matrix and the cells’ interior, thus providing cellular responsiveness to the extracellular environment (Tamkun et al., 1986; Buck and Horowitz, 1987). Integrin-ligand specificity is conferred by the subunit composition of the integrin heterodimer (a) complex (Hynes, 1987; Ruoslahti and Pierschbacher, 1987). In some cases, a given integrin heterodimer may recognize multiple ligands, or multiple integrins may recognize common ligands. The biological function underlying this intrinsic multiplicity and redundancy in ligand-integrin interaction is not well understood.
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Cheresh, D.A. (1994). The Biological Function of β3 Integrins and Other Vitronectin Receptors. In: Metcalf, B.W., Dalton, B.J., Poste, G., Schatz, J. (eds) Cellular Adhesion. New Horizons in Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2466-3_1
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DOI: https://doi.org/10.1007/978-1-4615-2466-3_1
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