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Macro and Micro Autoradiographic Studies on Oxalate in Normal and Hyperoxaluric Rats

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Urolithiasis 2

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Abstract

It is known that the deposition of calcium oxalate crystals in the kidney is the first stage of stone formation. However, the exact location of this deposition in the kidney has not been determined. Hautmann and Oßwald1 pointed out that there was a concentration gradient of oxalate and calcium from cortex to medulla of the kidney, and that oxalate and calcium contents in the papilla were hundred times higher than those in urine. These findings indicated that the renal papilla, especially the interstitium of papilla might be the site of the calcium oxalate crystalluric deposition. In the present study, we performed autoradiographic studies on oxalate in hyperoxaluric rats using 14C-oxalate, in order to elucidate the distribution of oxalate in renal tissue and the site of the deposition of calcium oxalate crystals along the nephron.

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References

  1. Hautmann R, Oßiwald H Concentration profile of calcium and oxalate in urine, tubular fluid and renal tissue — some theoretical considerations, J Urol 129: 433–436 (1983).

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  2. Imaoka S, Funae Y, Sugimoto T, Hayahara N, Maekawa M, Specific and rapid assay of urinary oxalic acid using high-performance liquid chromatography, Anal Biochem 128: 459–464 (1983).

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  3. Robertson WG, Peacock M, Ouimet D, Heyburn PJ, The main risk factor for calcium oxalate stone disease in man: Hyperoxaluria or mild hyperoxaluria?, Urolithiasis Plenum 3-12 (1980).

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  4. Knight TF, Senekjian HO, Weinman EJ, Effect of para-amino-hippurate on renal transport of oxalate Kidney Int 15: 38–42 (1979).

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Author information

Authors and Affiliations

  1. Department of Urology, Osaka City University Medical School, Osaka, Japan

    T. Kanazawa, T. Sugimoto, S. Kamikawa, H. Iimori, K. Yamamoto, T. Nakatani & T. Kishimoto

  2. Department of Chemistry, Osaka City University Medical School, Osaka, Japan

    Y. Funae

  3. Department of Pharmacy, Tübingen University, Germany

    H. Oßwald

Authors
  1. T. Kanazawa
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  2. T. Sugimoto
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  3. S. Kamikawa
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  4. H. Iimori
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  5. K. Yamamoto
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  6. T. Nakatani
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  7. H. Oßwald
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  8. Y. Funae
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  9. T. Kishimoto
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Editor information

Editors and Affiliations

  1. Flinders Medical Centre, South Australia, Australia

    Rosemary Ryall  & Villis R. Marshall  & 

  2. Institute of Medical and Veterinary Science, Adelaide, Australia

    Renze Bais  & Allan M. Rofe  & 

  3. Mayo Clinic, Rochester, Minnesota, USA

    Lynwood H. Smith

  4. University of British Columbia, Vancouver, British Columbia, Canada

    Valerie R. Walker

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© 1994 Springer Science+Business Media New York

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Kanazawa, T. et al. (1994). Macro and Micro Autoradiographic Studies on Oxalate in Normal and Hyperoxaluric Rats. In: Ryall, R., Bais, R., Marshall, V.R., Rofe, A.M., Smith, L.H., Walker, V.R. (eds) Urolithiasis 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2556-1_37

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  • DOI: https://doi.org/10.1007/978-1-4615-2556-1_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6091-9

  • Online ISBN: 978-1-4615-2556-1

  • eBook Packages: Springer Book Archive

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