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Growth factors and lung cancer

  • Chapter
Lung Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 72))

Abstract

Lung cancer is the principal cause of cancer deaths in the Western world. New approaches to its treatment are urgently needed. It is likely that these will arise from a better understanding of the extracellular factors and intracellular molecular events that are responsible for sustaining its growth.

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References

  1. Smyth JF, Fowlie SM, Gregor A, Crompton GK, Busutill A, Leonard RCF, Grant IWB. 1986. The impact of chemotherapy on small cell carcinoma of the bronchus. QJ Med 61:969–976.

    CAS  Google Scholar 

  2. Sorenson GD, Pettengill OS, Brinck-Johnsen T, Cate CC, Maurer LH. 1981. Hormone production by cultures of small-cell carcinoma of the lung. Cancer 47:1289–1296.

    Article  PubMed  CAS  Google Scholar 

  3. Maurer LH. 1985. Ectopic hormone syndrome in small cell carcinoma of the lung. Clin Oncol 4:1289–1296.

    Google Scholar 

  4. Wood SM, Wood JR, Ghatei MA, Lee YC, O’Shaughnessy D, Bloom SR. 1981. Bombesin, somatostatin and neurotensin-like immunoreactivity in bronchial carcinoma. J Clin Endocrinol Metab 53:1310–1312.

    Article  PubMed  CAS  Google Scholar 

  5. North WG, Maurer LH, Valtin H, O’Donnell JF. 1980. Human neurophysins as potential tumor markers for small cell carcinoma of the lung: application of specific radioimmunoassays. J Clin Endocrinol Metab 51: 892–896.

    Article  PubMed  CAS  Google Scholar 

  6. Goedert M, Reeve JG, Emson PC, Bleehen NM. 1984. Neurotensin in human small cell lung carcinoma. Br J Cancer 50:179–183.

    Article  PubMed  CAS  Google Scholar 

  7. Sausville E, Carney D, Battey J. 1985. The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line. J Biol Chem 260(18):10236–10241.

    PubMed  CAS  Google Scholar 

  8. Cuttitta F, Carney DN, Mulshine J, Moody TW, Fedorko F, Fischler A, Minna JD. 1985. Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer. Nature 316(6031):823–826.

    Article  PubMed  CAS  Google Scholar 

  9. Heimbrook DC, Boyer ME, Garsky VM, Balishin NL, Kiefer DM, Oliff A, Riemen MW. 1988. Minimal ligand analysis of gastrin releasing peptide. Receptor binding and mitogenesis. J Biol Chem 263(15):7016–7019.

    PubMed  CAS  Google Scholar 

  10. Rozengurt E, Sinnett-Smith J. 1983. Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells. Proc Natl Acad Sci USA 80:2936–2940.

    Article  PubMed  CAS  Google Scholar 

  11. Lhoste EF, Longnecker DS. 1987. Effect of bombesin and caerulein on early stages of carcinogenesis induced by azaserine in the rat pancreas. Cancer Res 47(12):3273–3277.

    PubMed  CAS  Google Scholar 

  12. Lehy T, Accary JP, Labeille D, Dubrasquet M. 1983. Chronic administration of bombesin stimulates antral gastrin cell proliferation in rat. Gastroenterology 84:914–919.

    PubMed  CAS  Google Scholar 

  13. Douglas BR, Woutersen RA, Jansen JB, Rovati LC, Lamers CB. 1989. Study into the role of cholecystokinin in bombesin-stimulated pancreatic growth in rats and hamsters. Eur J Pharmacol 161(2–3):209–214.

    Article  PubMed  CAS  Google Scholar 

  14. Chung DH, Evers BM, Beauchamp RD, Upp JR, Rajaraman S, Townsend CM, Thompson JC. 1992. Bombesin stimulates growth of human gastrinoma. Surgery 112: 1059–1065.

    PubMed  CAS  Google Scholar 

  15. Yano T, Pinski J, Groot K, Schally AV. 1992. Stimulation by bombesin and inhibition by bombesin/gastrin-releasing peptide antagonist RC-3095 of growth of human breast cancer cell lines. Cancer Res 52:4545–4547.

    PubMed  CAS  Google Scholar 

  16. Vangsted AJ, Andersen EV, Nedergaard L, Zeuthen J. 1991. Gastrin releasing peptide GRP(14-27) in human breast cancer cells and in small cell lung cancer. Breast Cancer Res Treat 19(2):119–128.

    Article  PubMed  CAS  Google Scholar 

  17. Pagani A, Papotti M, Sanfilippo B, Bussolati G. 1991. Expression of the gastrin-releasing peptide gene in carcinomas of the breast. Int J Cancer 47(3):371–375.

    Article  PubMed  CAS  Google Scholar 

  18. Moody TW. 1984. Bombesin-like peptides in the normal and malignant lung. In The Endocrine Lung in Health and Disease, KL Becker and AF Gazdar (eds.). W.B. Saunders: Philadelphia, pp. 328–335.

    Google Scholar 

  19. Spindel ER, Sunday ME, Hofler H, Wolfe HJ, Habener JF, Chin WW. 1987. Transient elevation of messenger RNA encoding gastrin-releasing peptide, a putative pulmonary growth factor in human fetal lung. J Clin Invest 80(4):1172–1179.

    Article  PubMed  CAS  Google Scholar 

  20. Cuttitta F, Fedorko J, Gu JA, Lebacq VA, Linnoila RI, Battey JF. 1988. Gastrin-releasing peptide gene-associated peptides are expressed in normal human fetal lung and small cell lung cancer: a novel peptide family found in man. J Clin Endocrinol Metab 67(3):576–583.

    Article  PubMed  CAS  Google Scholar 

  21. Ghatei MA, Sheppard MN, Henzen-Logman S, Blank MA, Polak JM, Bloom SR. 1983. Bombesin and vasoactive intestinal peptide in the developing lung: marked changes in the respiratory distress syndrome. J Clin Endocrinol Metab 57:1226–1232.

    Article  PubMed  CAS  Google Scholar 

  22. Willey JC, Lechner JF, Harris CC. 1984. Bombesin and the C-terminal tetradecapeptide of gastrin-releasing peptide are growth factors for normal human bronchial epithelial cells. Exp Cell Res 153:245–248.

    Article  PubMed  CAS  Google Scholar 

  23. Schuller H. 1991. Receptor-mediated mitogenic signals and lung cancer. Cancer Cells 3:496–503.

    PubMed  CAS  Google Scholar 

  24. Aguayo SM, King TJ, Waldron JJ, Sherritt KM, Kane MA, Miller YE. 1990. Increased pulmonary neuroendocrine cells with bombesin-like immunoreactivity in adult patients with eosinophilic granuloma. J Clin Invest 86(3):838–844.

    Article  PubMed  CAS  Google Scholar 

  25. Moody TW, Pert CB, Gazdar AF, Carney DN, Minna JD. 1981. High levels of intracellular bombesin characterize human small-cell lung carcinoma. Science 214:1246–1248.

    Article  PubMed  CAS  Google Scholar 

  26. Bork E, Hansen M, Urdal P, Paus E, Holst JJ, Schifter S, Fenger M, Engbaek F. 1988. Early detection of response in small cell bronchogenic carcinoma by changes in serum concentrations of creatine kinase, neuron specific enolase, calcitonin, ACTH, serotonin and gastrin releasing peptide. Eur J Cancer Clin Oncol 24(6):1033–1038.

    Article  PubMed  CAS  Google Scholar 

  27. Sunday ME, Choi N, Spindel ER, Chin WW, Mark EJ. 1991. Gastrin-releasing peptide gene expression in small cell and large cell undifferentiated lung carcinomas. Hum Pathol 22(10): 1030–1039.

    Article  PubMed  CAS  Google Scholar 

  28. Sausville EA, Lebacq-Verheyden AM, Spindel ER, Cuttitta F, Gazdar AF, Battey JF. 1986. Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs. J Biol Chem 261(5):2451–2457.

    PubMed  CAS  Google Scholar 

  29. Moody TW, Carney DN, Cuttitta F, Quattrocchi K, Minna JD. 1985. High affinity receptors for bombesin/GRP-like peptides on human small cell lung cancer. Life Sci 37(2):105–113.

    Article  PubMed  CAS  Google Scholar 

  30. Layton JE, Scanlon DB, Soveny C, Morstyn G. 1988. Effects of bombesin antagonists on the growth of small cell lung cancer cells in vitro. Cancer Res 48(17):4783–4789.

    PubMed  CAS  Google Scholar 

  31. Corjay MH, Dobrzanski DJ, Way JM, Viallet J, Shapira H, Worland P, Sausville EA, Battey JF. 1991. Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells. J Biol Chem 266(28): 18771–18779.

    PubMed  CAS  Google Scholar 

  32. Kado-Fong H, Malfroy B. 1989. Effects of bombesin on human small cell lung cancer cells: Evidence for a subset of bombesin non-responsive cell lines. J Cell Biochem 40(4): 431–437.

    Article  PubMed  CAS  Google Scholar 

  33. Rozengurt E. 1991. Neuropeptides as cellular growth factors: role of multiple signalling pathways. Eur J Clin Invest 21:123–134.

    Article  PubMed  CAS  Google Scholar 

  34. Sharoni Y, Viallet J, Trepel JB, Sausville EA. 1990. Effect of guanine and adenine nucleotides on bombesin-stimulated phospholipase C activity in membranes from Swiss 3T3 and small cell lung carcinoma cells. Cancer Res 50(17):5257–5262.

    PubMed  CAS  Google Scholar 

  35. Trepel JB, Moyer JD, Heikkila R, Sausville EA. 1988. Modulation of bombesin-induced phosphatidylinositol hydrolysis in a small-cell lung-cancer cell line. Biochem J 255(2): 403–410.

    PubMed  CAS  Google Scholar 

  36. Heikkila R, Trepel JB, Cuttitta F, Neckers LM, Sausville EA. 1987. Bombesin-related peptides induce calcium mobilization in a subset of human small cell lung cancer cell lines. J Biol Chem 262:16456–16460.

    PubMed  CAS  Google Scholar 

  37. Weber S, Zuckerman JE, Bostwick DG, Bensch KG, Sikic BI, Raffin TA. 1985. Gastrin releasing peptide is a selective mitogen for small cell lung carcinoma in vitro. J Clin Invest 75(1):306–309.

    Article  PubMed  CAS  Google Scholar 

  38. Carney DN, Cuttitta F, Moody TW, Minna JD. 1987. Selective stimulation of small cell lung cancer clonal growth by bombesin and gastrin-releasing peptide. Cancer Res 47(3): 821–825.

    PubMed  CAS  Google Scholar 

  39. Alexander RW, Upp JJ, Poston GJ, Gupta V, Townsend CJ, Thompson JC. 1988. Effects of bombesin on growth of human small cell lung carcinoma in vivo. Cancer Res 48(6): 1439–1441.

    PubMed  CAS  Google Scholar 

  40. Kelley MJ, Avis I, Linnoila RI, Richardson G, Snider R, Phares J, et al. 1993. Complete response in a patient with small cell lung cancer (SCLC) treated on a phase II trial using a murine monoclonal antibody (2A11) directed against gastrin releasing peptide. Proc Am Soc Clin Oncol 12:339.

    Google Scholar 

  41. Luster W, Gropp C, Kern HF, Havemann K. 1985. Lung tumour cell lines synthesizing peptide hormones established from tumours of four histological types: Characterization of the cell lines and analysis of their peptide hormone production. Br J Cancer 51(6): 865–875.

    Article  PubMed  CAS  Google Scholar 

  42. Becker KL, Silva OL, Gazdar AF, Snider RH, Moore CF. 1984. Calcitonin and small cell cancer of the lung. In The Endocrine Lung in Health and Disease, KL Becker and AF Gazdar (eds.). W.B. Saunders: Philadelphia, pp. 528–548.

    Google Scholar 

  43. Bliss De, Battey JF, Linnoila RI, Birrer MJ, Gazdar AF, Johnson BE. 1990. Expression of the atrial natriuretic factor gene in small cell lung cancer tumors and tumor cell lines. Jr Natl Cancer Inst 82(4):305–310.

    Article  CAS  Google Scholar 

  44. Gross AJ, Steinberg SM, Reilly JG, Bliss DP, Brennan J, Tram Le P, Simmons A, Phelps R, Mulshine JL, Ihde DC, Johnson BE. 1993. Atrial natriuretic factor and arginine vasopressin production in tumor cell lines from patients with lung cancer and their relationship to serum sodium. Cancer Res 53:67–74.

    PubMed  CAS  Google Scholar 

  45. Bepler G, Rotsch M, Jaques G, Haeder M, Heymanns J, Hartogh G, Kiefer P, Havemann K. 1988. Peptides and growth factors in small cell lung cancer: production, binding sites, and growth effects. J Cancer Res Clin Oncol 114(3):235–244.

    Article  PubMed  CAS  Google Scholar 

  46. Moody TW. 1988. Neuropeptide receptors on small cell lung cancer cells. Lung Cancer 4:186.

    Article  Google Scholar 

  47. Rehfeld JF, Bardram L, Hilsted L. 1989. Gastrin in human bronchogenic carcinomas: Constant expression but variable processing of progastrin. Cancer Res 49(11):2840–2843.

    PubMed  CAS  Google Scholar 

  48. Gazdar AF, Carney DN. 1984. Endocrine properties of small cell carcinoma of the lung. In The Endocrine Lung in Health and Disease, KL Becker and AF Gazdar (eds.). W.B. Saunders: Philadelphia, pp. 501–508.

    Google Scholar 

  49. Erisman MD, Linnoila RI, Hernandez O, DiAugustine RP, Lazarus LH. 1982. Human lung small-cell carcinoma contains bombesin. Proc Natl Acad Sci USA 79:2379–2383.

    Article  PubMed  CAS  Google Scholar 

  50. Abe K, Kameya T, Yamaguchi K, Kikuchi K, Adachi I, Tanaka M, Kimura S, Kodama T, Shimosato Y, Ishikawa S. 1984. Hormone-producing lung cancers: endocrinologic and morphologic studies. In The Endocrine Lung in Health and Disease, KL Becker and AF Gazdar (eds.). W.B. Saunders Philadelphia, pp. 549–595.

    Google Scholar 

  51. Macaulay VM, Everard MJ, Teale JD, Trott PA, Van-Wyk JJ, Smith IE, Millar JL. 1990. Autocrine function for insulin-like growth factor I in human small cell lung cancer cell lines and fresh tumor cells. Cancer Res 50(8):2511–2517.

    PubMed  CAS  Google Scholar 

  52. Reeve JG. 1991. Expression of insulin-like growth factor (IGF) and IGF binding protein genes in human lung tumor cell lines (meeting abstract). Br J Cancer ••.

    Google Scholar 

  53. Jaques G, Kiefer P, Rotsch M, Hennig C, Goke R, Richter G, Havemann K. 1989. Production of insulin-like growth factor binding proteins by small-cell lung cancer cell lines. Exp Cell Res 184(2):396–406.

    Article  PubMed  CAS  Google Scholar 

  54. Kiefer P, Jaques G, Schoneberger J, Heinrich G, Havemann K. 1991. Insulin-like growth factor binding protein expression in human small cell lung cancer cell lines. Exp Cell Res 192(2):414–417.

    Article  PubMed  CAS  Google Scholar 

  55. Giaccone G, Battey J, Gazdar AF, Oie H, Draoui M, Moody TW. 1992. Neuromedin B is present in lung cancer cell lines. Cancer Res 52:52732–52736.

    Google Scholar 

  56. Cardona C, Rabbitts PH, Spindel ER, Ghatei MA, Bleehen NM, Bloom SR, Reeve JG. 1991. Production of neuromedin B and neuromedin B gene expression in human lung tumor cell lines. Cancer Res 51(19):5205–5211.

    PubMed  CAS  Google Scholar 

  57. Moody TW, Carney DN, Korman LY, Gazdar AF, Minna JD. 1985. Neurotensin is produced by and secreted from classic small cell lung cancer cells. Life Sci 36(18): 1727–1732.

    Article  PubMed  CAS  Google Scholar 

  58. Roth KA, Barchas JD. 1986. Small cell carcinoma cell lines contain opioid peptides and receptors. Cancer 57:769–773.

    Article  PubMed  CAS  Google Scholar 

  59. Yoshimoto K, Yamasaki R, Sakai H, Tezuka U, Takahashi M, Iizuka M, Sekiya T, Saito S. 1989. Ectopic production of parathyroid hormone by small cell lung cancer in a patient with hypercalcemia. J Clin Endocrinol Metab 68(5):976–981.

    Article  PubMed  CAS  Google Scholar 

  60. Lazarus LH, Hernandez O. 1985. Physalaemin-like immunoreactivity from human lung small cell carcinoma: isocratic reversed-phase hplc analysis of the chemically modified peptide. Recent Results Cancer Res 99(56):56–66.

    PubMed  CAS  Google Scholar 

  61. Hibi K, Takahashi T, Sekido Y, Ueda R, Hida T, Ariyoshi Y, Takagi H, Takahashi T. 1991. Coexpression of the stem cell factor and the c-kit genes in small-cell lung cancer. Oncogene 6(12):2291–2296.

    PubMed  CAS  Google Scholar 

  62. Nakanishi Y, Cuttitta F, Kasprzyk PG, Avis I, Steinberg SM, Gazdar AF, Mulshine JL. 1988. Growth factor effects on small cell lung cancer cells using a colorimetric assay: can a transferrin-like factor mediate autocrine growth? Exp Cell Biol 56(1–2):74–85.

    PubMed  CAS  Google Scholar 

  63. Gozes I, Nakai H, Byers M, Avidor R, Weinstein Y, Shani Y, Shows TB. 1987. Sequential expression in the nervous system of c-myb and VIP genes, located in human chromosomal region 6q24. Somat Cell Mol Genet 13(4):305–313.

    Article  PubMed  CAS  Google Scholar 

  64. Becker KL, Gazdar AF. 1985. What can the biology of small cell cancer of the lung teach us about the endocrine lung? Biochem Pharmacol 34(2): 155–159.

    Article  PubMed  CAS  Google Scholar 

  65. Quinn KA, Treston AM, Scott FM, Kasprzyk PG, Avis I, Siegfried JM, Mulshine JL, Cuttitta F. 1991. Alpha-amidation of peptide hormones in lung cancer. Cancer Cells 3(12):504–510.

    PubMed  CAS  Google Scholar 

  66. Woll PJ, Rozengurt E. 1989. Multiple neuropeptides mobilise calcium in small cell lung cancer: Effects of vasopressin, bradykinin, cholecystokinin, galanin and neurotensin. Biochem Biophys Res Commun 164(1):66–73.

    Article  PubMed  CAS  Google Scholar 

  67. Sethi T, Rozengurt E. 1991. Galanin stimulates Ca2+ mobilization, inositol phosphate accumulation, and clonal growth in small cell lung cancer cells. Cancer Res 51(6): 1674–1679.

    PubMed  CAS  Google Scholar 

  68. Staley J, Fiskum G, Moody TW. 1989. Cholecystokimn elevates cytosolic calcium in small cell lung cancer cells. Biochem Biophys Res Commun 163:605–610.

    Article  PubMed  CAS  Google Scholar 

  69. Staley J, Fiskum G, Davis TP, Moody TW. 1989. Neurotensin elevates cytosolic calcium in small cell lung cancer cells. Peptides 10:1217–1221.

    Article  PubMed  CAS  Google Scholar 

  70. Bunn PA, Dienhart DG, Chan D, Puck TT, Tagawa M, Jewett PB, Braunschweiger E. 1990. Neuropeptide stimulation of calcium flux in human lung cancer cells: Delineation of alternative pathways. Proc Natl Acad Sci USA 87(6):2162–2166.

    Article  PubMed  CAS  Google Scholar 

  71. Dunne MJ, Bullett MJ, Li GD, Wollheim CB, Petersen OH. 1989. Galanin activates nucleotide-dependent K+ channels in insulin-secreting cells via a pertussis toxin-sensitive G-protein. EMBO J 8:413–420.

    PubMed  CAS  Google Scholar 

  72. Jensen RT, Wank SA, Rowley WH, Sato S, Gardner JD. 1989. Interaction of CCK with pancreatic acinar cells. Trends Pharmacol Sci 10:418–423.

    Article  PubMed  CAS  Google Scholar 

  73. Sethi T, Rozengurt E. 1992. Gastrin stimulates Ca(2+) mobilization and clonal growth in small cell lung cancer cells. Cancer Res 52(21):6031–6035.

    PubMed  CAS  Google Scholar 

  74. Sethi T, Rozengurt E. 1991. Multiple neuropeptides stimulate clonal growth of small cell lung cancer: effects of bradykinin, vasopressin, cholecystokinin, galanin, and neurotensin. Cancer Res 52(13):3621–3623.

    Google Scholar 

  75. Woll PJ, Rozengurt E. 1990. A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer Res 50(13):3968–3973.

    PubMed  CAS  Google Scholar 

  76. Millar JBA, Rozengurt E. 1989. Heterologous desensitization of bombesin-induced mitogenesis by prolonged exposure to vasopressin: a post-receptor signal transduction block. Proc Natl Acad Sci USA 86(9):3204–3208.

    Article  PubMed  CAS  Google Scholar 

  77. Millar JBA, Rozengurt E. 1990. Chronic desensitization to bombesin by progressive down-regulation of bombesin receptors in Swiss 3T3 cells. Distinction from acute desensitization. J Biol Chem 265(20): 12052–12058.

    PubMed  CAS  Google Scholar 

  78. Clemmons DR. 1989. Structural and functional analysis of insulin-like growth factors. Br Med Bull 45:465–480.

    PubMed  CAS  Google Scholar 

  79. Czech MP. 1989. Signal transmission by the insulin-like growth factors. Cell 59:235–238.

    Article  PubMed  CAS  Google Scholar 

  80. Rosen N, Yee D, Lippman ME, Paik S, Cullen KJ. 1991. Insulin-like growth factors in human breast cancer. Breast Cancer Res Treat 18:51.

    Article  Google Scholar 

  81. Williams DW, Williams ED, Wynford-Thomas D. 1989. Evidence for autocrine production of IGF-I in human thyroid adenomas. Mol Cell Endocrinol 61(1):139–143••.

    Article  PubMed  CAS  Google Scholar 

  82. Simms E, Gazdar AF, Abrams PG, Minna JD. 1980. Growth of human small cell (oat cell) carcinoma of the lung in serum-free growth factor-supplemented medium. Cancer Res 40:4356–4363.

    PubMed  CAS  Google Scholar 

  83. Minuto F, Del MP, Barreca A, Alama A, Cariola G, Giordano G. 1988. Evidence for autocrine mitogenic stimulation by somatomedin-c/insulin-like growth factor I on an established human lung cancer cell line. Cancer Res 48(13):3716–3719.

    PubMed  CAS  Google Scholar 

  84. Macauly VM, Teale JD, Everard MJ, Joshi GP, Smith IE, Millar JL. 1988. Somatomedin-C/insulin-like growth factor-I is a mitogen for human small cell lung cancer. Br J Cancer 57(1):91–93.

    Article  PubMed  CAS  Google Scholar 

  85. Jaques G, Rotsch M, Wegmann C, Worsch U, Maasberg M, Havemann K. 1988. Production of immunoreactive insulin-like growth factor I and response to exogenous IGF-I in small cell lung cancer cell lines. Exp Cell Res 176(2):336–343.

    Article  PubMed  CAS  Google Scholar 

  86. Havemann K, Rotsch M, Schoneberger HJ, Erbil C, Hennig C, Jaques G. 1990. Growth regulation by insulin-like growth factors in lung cancer. J Steroid Biochem Mol Biol 37(6):877–882.

    Article  PubMed  CAS  Google Scholar 

  87. Nakanishi Y, Mulshine JL, Kasprzyk PG, Natale, RB, Maneckjee R, Avis I, Treston AM, Gazdar AF, Minna JD, Cuttitta F. 1988. Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro. J Clin Invest 82(1):354–359.

    Article  PubMed  CAS  Google Scholar 

  88. Schardt C, Rotsch M, Erbil C, Goke R, Richter G, Havemann K. 1993. Characterization of insulin-like growth factor II receptors in human small cell lung cancer cell lines. Exp Cell Res 204(1):22–29.

    Article  PubMed  CAS  Google Scholar 

  89. Vostrejs M, Moran PL, Seligman PA. 1988. Transferrin synthesis by small cell lung cancer cells acts as an autocrine regulator of cellular proliferation. J Clin Invest 82(1):331–339.

    Article  PubMed  CAS  Google Scholar 

  90. Cavanaugh PG, Nicolson GL. 1991. Lung-derived growth factor that stimulates the growth of lung-metastasizing tumor cells: Identification as transferrin. J Cell Biochem 47(3):261–271.

    Article  PubMed  CAS  Google Scholar 

  91. Nakamura H, Sayami P, Hayata Y. 1992. Analysis of G-CSF-producing lung cancer cell lines and non-growth stimulatory effects of rhG-CSF on lung cancer cells in vitro and in vivo. Lung Cancer 8:141–152.

    Article  Google Scholar 

  92. Foulke RS, Marshall MH, Trotta PP, van Hoff DD. 1990. In vitro assessment of the effects of granulocyte-macrophage colony-stimulating factor on primary human tumors and cell lines. Cancer Res 50:6264–6267.

    PubMed  CAS  Google Scholar 

  93. Baldwin GC, Gasson JC, Kaufman SE, et al. 1989. Nonhematopoietic tumor cells express functional GM-CSF receptors. Blood 73:1033–1037.

    PubMed  CAS  Google Scholar 

  94. Avalos BR, Gasson JC, Hedrat C, et al. 1990. Human granulocyte colony-stimulating factor: biologic activities and receptor characterization on hematopoietic cells and small cell lung cancer cell lines. Blood 75:851–859.

    PubMed  CAS  Google Scholar 

  95. Yamashita Y, Nara N, Aoki N. 1989. Antiproliferative and differentiative effect of granulocyte-macrophage colony-stimulating factor on a variant human small cell lung cancer cell line. Cancer Res 49:5334–5338.

    PubMed  CAS  Google Scholar 

  96. Ruff MR, Farrar WL, Pert CB. 1986. Interferon gamma and granulocyte/macrophage colony-stimulating factor inhibit growth and induce antigens characteristic of myeloid differentiation in small-cell lung cancer cell lines. Proc Natl Acad Sci USA 83(17): 6613–6617.

    Article  PubMed  CAS  Google Scholar 

  97. Twentyman PR, Wright KA. 1991. Failure of GM-CSF to influence the growth of small cell and non-small cell lung cancer cell lines in vitro. Eur J Cancer 27:6–8.

    Article  PubMed  CAS  Google Scholar 

  98. Vellenga E, Biesma B, Meyer C, Wagteveld L, Esselink M, de VE. 1991. The effects of five hematopoietic growth factors on human small cell lung carcinoma cell lines: Interleukin 3 enhances the proliferation in one of the eleven cell lines. Cancer Res 51(1):73–76.

    PubMed  CAS  Google Scholar 

  99. Nemunaitis J, Singer JW. 1989. The effect of recombinant human granulocyte macrophage-colony stimulating factor (rhGM-CSF) and recombinant human interleukin-1 (rhIL-1) on proliferation of human tumor cell lines. Cancer J 2(11):369–372.

    CAS  Google Scholar 

  100. Rygaard K, Nakamura T, Spang TM. 1993. Expression of the proto-oncogenes c-met and c-kit and their ligands, hepatocyte growth factor/scatter factor and stem cell factor, in SCLC cell lines and xenografts. Br J Cancer 67(1):37–46.

    Article  PubMed  CAS  Google Scholar 

  101. Sekido Y, Takahashi T, Ueda R, Takahashi M, Suzuki H, Nishida K, Tsukamoto T, Hida T, Shimokata K, Zsebo KM, Takahashi T. 1993. Recombinant human stem cell factor mediates chemotaxis of small cell lung cancer cell lines aberrantly expressing the c-kit protooncogene. Cancer Res 53:1709–1714.

    PubMed  CAS  Google Scholar 

  102. Snyder SH. 1980. Brain peptides as neurotransmitters. Science 209:976–983.

    Article  PubMed  CAS  Google Scholar 

  103. Davis TP, Burgess HS, Crowell S, Moody TW, Culling BA, Liu RH. 1989. Beta-endorphin and neurotensin stimulate in vitro clonal growth of human SCLC cells. Eur J Pharmacol 161(2–3):283–285.

    Article  PubMed  CAS  Google Scholar 

  104. Feuerstein G, Molineaux CJ, Rosenberger JG, Zerbe RL, Cox BM, Faden AI. 1985. Hemorrhagic shock and the central vasopressin and opioid peptide system of rats. Am J Physiol 249:E244–E250.

    PubMed  CAS  Google Scholar 

  105. Zhu YX, Hsi KL, Chen ZG, Zhang HL, Wu SX, Zhang SY, Fang PF, Guo SY, Kao YS, Tsou K. 1986. Neo-kyotorphin, an analgesic peptide isolated from human lung carcinoma. FEBS Lett 208(2):253–257.

    Article  PubMed  CAS  Google Scholar 

  106. Maneckjee R, Minna JD. 1990. Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines. Proc Natl Acad Sci USA 87(9):3294–3298.

    Article  PubMed  CAS  Google Scholar 

  107. Maneckjee R, Minna JD. 1992. Nonconventional opioid binding sites mediate growth inhibitory effects of methadone on human lung cancer cells. Proc Natl Acad Sci USA 89(4):1169–1173.

    Article  PubMed  CAS  Google Scholar 

  108. Zagon IS, McLaughlin PJ. 1987. Modulation of murine neuroblastoma in nude mice by opioid antagonists. J Natl Cancer Inst 78(1): 141–147.

    PubMed  CAS  Google Scholar 

  109. Takuwa N, Takuwa Y, Ohue Y, Mukai H, Endoh K, Yamashita K, Kumada M, Munekata E. 1990. Stimulation of calcium mobilization but not proliferation by bombesin and tachykinin neuropeptides in human small cell lung cancer cells. Cancer Res 50(2): 240–244.

    PubMed  CAS  Google Scholar 

  110. Nilsson T, Arkhammar P, Rorsman P, Berggren PO. 1989. Suppression of insulin release by galanin and somatostatin is mediated by a G-protein. An effect involving repolarization and reduction in cytoplasmic free Ca2+ concentration. J Biol Chem 264:973–980.

    PubMed  CAS  Google Scholar 

  111. Scambia G, Panici PB, Baiocchi G, Perrone L, Iacobelli S, Mancuso S. 1988. Antiproliferative effects of somatostatin and the somatostatin analog SMS 201-995 on three human breast cancer cell lines. J Cancer Res Clin Oncol 114(3):306–308.

    Article  PubMed  CAS  Google Scholar 

  112. Schally AV. 1988. Oncological applications of somatostatin analogues. Cancer Res 48: 6977–6985.

    PubMed  CAS  Google Scholar 

  113. Murphy WA, Lance VA, Moreau S, Moreau JP, Coy DH. 1987. Inhibition of rat prostate tumor growth by an octapeptide analog of somatostatin. Life Sci 40(26):2515–2522.

    Article  PubMed  CAS  Google Scholar 

  114. Reubi JC, Laissue J, Krenning E, Lamberts SW. 1992. Somatostatin receptors in human cancer: Incidence, characteristics, functional correlates and clinical implications. J Steroid Biochem Mol Biol 43(1–3):27–35.

    Article  PubMed  CAS  Google Scholar 

  115. Reubi JC, Waser B, Sheppard M, Macaulay V. 1990. Somatostatin receptors are present in small-cell but not in non-small-cell primary lung carcinomas: Relationship to EGF-receptors. Int J Cancer 45(2):269–274.

    Article  PubMed  CAS  Google Scholar 

  116. Gorden P, Comi RJ, Maton PN, Go VL. 1989. Somatostatin and somatostatin analogue (SMS 201-995) in treatment of hormone-secreting tumors of the pituitary and gastrointestinal tract and non-neoplastic diseases of the gut. Ann Intern Med 110(1):35–50.

    PubMed  CAS  Google Scholar 

  117. Taylor JE, Bogden AE, Moreau JP, Coy DH. 1988. In vitro and in vivo inhibition of human small cell lung carcinoma (NCI-H69) growth by a somatostatin analogue. Biochem Biophys Res Commun 153(1):81–86.

    Article  PubMed  CAS  Google Scholar 

  118. Taylor JE, Moreau JP, Baptiste L, Moody TW. 1991. Octapeptide analogues of somatostatin inhibit the clonal growth and vasoactive intestinal peptide-stimulated cyclic amp formation in human small cell lung cancer cells. Peptides 12(4):839–843.

    Article  PubMed  CAS  Google Scholar 

  119. Macaulay VM, Smith IE, Everard MJ, Teale JD, Reubi JC, Millar JL. 1991. Experimental and clinical studies with somatostatin analogue octreotide in small cell lung cancer. Br J Cancer 64(3):451–456.

    Article  PubMed  CAS  Google Scholar 

  120. Gazdar AF, Bunn P Jr, Minna JD, Baylin SB. 1985. Origin of human small cell lung cancer. Science 229(4714):679–680.

    Article  PubMed  CAS  Google Scholar 

  121. World Health Organization. 1982. The World Health Organization. Histological typing of lung tumours. Neoplasma 29(1):111–123.

    Google Scholar 

  122. Graziano SL, Mazid R, Newman N, Tatum A, Oler A, Mortimer JA, et al. 1989. The use of neuroendocrine immunoperoxidase markers to predict chemotherapy response in patients with non small cell lung cancer. J Clin Oncol 7:1398–1406.

    PubMed  CAS  Google Scholar 

  123. Kamata N, Chida K, Rikimaru K, Horikoshi M, Enomoto S, Kuroki T. 1986. Growth-inhibitory effects of epidermal growth factor and overexpression of its receptors on human squamous cell carcinomas in culture. Cancer Res 46(4, Pt 1): 1648–1653.

    PubMed  CAS  Google Scholar 

  124. Damstrup L, Rygaard K, Spang TM, Poulsen HS. 1992. Expression of the epidermal growth factor receptor in human small cell lung cancer cell lines. Cancer Res 52(11): 3089–3093.

    PubMed  CAS  Google Scholar 

  125. Rabiasz GL, Langdon SP, Bartlett JM, Crew AJ, Miller EP, Scott WN, Smyth JF, Miller WR. 1992. Growth control by epidermal growth factor and transforming growth factor-alpha in human lung squamous carcinoma cells. Br J Cancer 66:254–259.

    Article  PubMed  CAS  Google Scholar 

  126. Haeder M, Rotsch M, Bepler G, Hennig C, Havemann K, Heimann B, Moelling K. 1988. Epidermal growth factor receptor expression in human lung cancer cell lines. Cancer Res 48(5):1132–1136.

    PubMed  CAS  Google Scholar 

  127. Söderdahl G, Betsholtz C, Johansson A, Nilsson K, Bergh J. 1988. Differential expression of platelet-derived growth factor and transforming growth factor genes in small-and non-small-cell lung carcinoma cell lines. Int J Cancer 41:636–641.

    Article  PubMed  Google Scholar 

  128. Veale D, Kerr N, Gibson GJ, Harris AL. 1989. Characterization of epidermal growth factor receptor in primary human non-small cell lung cancer. Cancer Res 49:1313–1317.

    PubMed  CAS  Google Scholar 

  129. Fang K, Li L, Jansen J, Fidler I, Roth JA. 1991. Brain metastatic variants of human lung cancer cells acquire independence from autocrine growth stimulation by TGF alpha. Proc Am Soc Clin Oncol 32:A302.

    Google Scholar 

  130. Putnam EA, Yen N, Gallick GE, Steck PA, Fang K, Akpakip B, Gazdar AF, Roth JA. 1992. Autocrine growth stimulation by transforming growth factor-alpha in human non-small cell lung cancer. Surg Oncol 1(1):49–60.

    Article  PubMed  CAS  Google Scholar 

  131. Lee M, Draoui M, Zia F, Gazdar A, Oie H, Bepler G, Bellot F, Tarr C, Kris R, Moody TW. 1992. Epidermal growth factor receptor monoclonal antibodies inhibit the growth of lung cancer cell lines. Monogr Natl Cancer Inst 13:112–123.

    Google Scholar 

  132. Jensen RT, Jones SW, Folkers K, Gardner JD. 1984. A synthetic peptide that is a bombesin receptor antagonist. Nature 309:61–63.

    Article  PubMed  CAS  Google Scholar 

  133. Zachary I, Rozengurt E. 1985. High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells. Proc Natl Acad Sci USA 82(22):7616–7620.

    Article  PubMed  CAS  Google Scholar 

  134. Sinnett-Smith J, Lehmann W, Rozengurt E. 1990. Bombesin receptor in membranes from Swiss 3T3 cells. Binding characteristics, affinity labelling and modulation by guanine nucleotides. Biochem J 265:485–493.

    PubMed  CAS  Google Scholar 

  135. Zachary I, Rozengurt E. 1986. A substance P antagonist also inhibits the specific binding and mitogenic effects of vasopressin and bombesin-related peptides in Swiss 3T3 cells. Biochem Biophys Res Commun 137:135–141.

    Article  PubMed  CAS  Google Scholar 

  136. Woll PJ, Rozengurt E. 1988. [D-Arg1,D-Phe5,D-Trp7,9,Leu11] substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro. Proc Natl Acad Sci USA 85(6):1859–1863.

    Article  PubMed  CAS  Google Scholar 

  137. Sethi T, Langdon S, Smyth J, Rozengurt E. 1992. Growth of small cell lung cancer cells: Stimulation by multiple neuropeptides and inhibition by broad spectrum antagonists in vitro and in vivo. Cancer Res 52:s2737-s2742.

    Google Scholar 

  138. Langdon S, Sethi T, Ritchie A, Muir M, Smyth J, Rozengurt E. 1992. Broad spectrum neuropeptide antagonists inhibit the growth of small cell lung cancer in vivo. Cancer Res 52(16):4554–4557.

    PubMed  CAS  Google Scholar 

  139. Modjtahedi H, Styles JM, Dean CJ. 1993. The human EGF receptor as a target for cancer therapy: six new rat mAbs against the receptor on the breast carcinoma MDA-MB 468. Br J Cancer 67:247–253.

    Article  PubMed  CAS  Google Scholar 

  140. Engström U, Engström A, Ernlund A, Westermark B, Heldin C-H. 1992. Identification of a peptide antagonist for platelet derived growth factor. J Biol Chem 267:16581–16587.

    PubMed  Google Scholar 

  141. Prendiville J, Crowther D, Thatcher N, et al. 1993. A phase I study of intravenous bryostatin 1 in patients with advanced cancer. Br J Cancer 68:418–424.

    Article  PubMed  CAS  Google Scholar 

  142. Levitzki A. 1992. Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction. FASEB J 6:3275–3282.

    PubMed  CAS  Google Scholar 

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Authors
  1. Tariq Sethi
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  2. Penella J. Woll
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  1. Department of Oncology 5074, Rigshospitalet, 9 Blegdamsvej, DK-2100, Copenhagen, Denmark

    Heine H. Hansen

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Sethi, T., Woll, P.J. (1994). Growth factors and lung cancer. In: Hansen, H.H. (eds) Lung Cancer. Cancer Treatment and Research, vol 72. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2630-8_5

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  • DOI: https://doi.org/10.1007/978-1-4615-2630-8_5

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